Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Sangsu, Bae"'
Autor:
Jae-Hyeok Kang, Nizam Uddin, Seungmo Kim, Yi Zhao, Ki-Chun Yoo, Min-Jung Kim, Sung-Ah Hong, Sangsu Bae, Jeong-Yeon Lee, Incheol Shin, Young Woo Jin, Heather M. O’Hagan, Joo Mi Yi, Su-Jae Lee
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-18 (2024)
Abstract Triple-negative breast cancer (TNBC), the most aggressive subtype, presents a critical challenge due to the absence of approved targeted therapies. Hence, there is an urgent need to identify effective therapeutic targets for this condition.
Externí odkaz:
https://doaj.org/article/6c5a1e8d71c14b51abf556d24cb132c7
Autor:
Yong Ryoul Kim, Jaegeon Joo, Hee Jung Lee, Chaelim Kim, Ju-Chan Park, Young Suk Yu, Chang Rok Kim, Do Hui Lee, Joowon Cha, Hyemin Kwon, Kimberley M. Hanssen, Thomas G. P. Grünewald, Murim Choi, Ilkyu Han, Sangsu Bae, Inkyung Jung, Yongdae Shin, Sung Hee Baek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles within cells, with implications in various biological processes and disease states. AT-rich interactive domain-containing protein 1A (ARID1A) is a chr
Externí odkaz:
https://doaj.org/article/f25add8b82e04306ab0c03db65ef7a2a
Enhancing genome editing in hPSCs through dual inhibition of DNA damage response and repair pathways
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Precise genome editing is crucial for establishing isogenic human disease models and ex vivo stem cell therapy from the patient-derived hPSCs. Unlike Cas9-mediated knock-in, cytosine base editor and prime editor achieve the desirable gene co
Externí odkaz:
https://doaj.org/article/8488b8ccf2a74db2981ac74daa8c80f5
Autor:
Ju A Shim, So Min Lee, Jin Woo Jeong, Hyori Kim, Woo Jae Son, Jun Hong Park, Parkyong Song, Sin-Hyeog Im, Sangsu Bae, Jung-Hyun Park, Yuna Jo, Changwan Hong
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Introduction Cytokines of the common γ chain (γc) family are critical for the development, differentiation, and survival of T lineage cells. Cytokines play key roles in immunodeficiencies, autoimmune diseases, allergies, and cancer. Althou
Externí odkaz:
https://doaj.org/article/baaa9c416720449ea76683b5ebbf1a39
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f24c5edfaba5461cbc88e7fbb56139cd
Autor:
Ju-Chan Park, Yun-Jeong Kim, Jun Hee Han, Dayeon Kim, Mihn Jeong Park, Jumee Kim, Hyeon-Ki Jang, Sangsu Bae, Hyuk-Jin Cha
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 914-922 (2023)
Precise genome editing in human pluripotent stem cells (hPSCs) has potential applications in isogenic disease modeling and ex vivo stem cell therapy, necessitating diverse genome editing tools. However, unlike differentiated somatic cells, hPSCs have
Externí odkaz:
https://doaj.org/article/cca6452d047a4d9db6862fc2cd99d5da
Autor:
Dong Hyun Jo, Hyeon-Ki Jang, Chang Sik Cho, Jun Hee Han, Gahee Ryu, Youngri Jung, Sangsu Bae, Jeong Hun Kim
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 16-27 (2023)
Leber congenital amaurosis (LCA), an inherited retinal degeneration, causes severe visual dysfunction in children and adolescents. In patients with LCA, pathogenic variants, such as RPE65, are evident in specific genes, related to the functions of re
Externí odkaz:
https://doaj.org/article/0e40f671c79f40dd9e740725b178edd1
Autor:
Jeonghun Kwon, Minyoung Kim, Woochang Hwang, Anna Jo, Gue-Ho Hwang, Minhee Jung, Un Gi Kim, Gang Cui, Heonseok Kim, Joon-Ho Eom, Junho K. Hur, Junwon Lee, Youngho Kim, Jin-soo Kim, Sangsu Bae, Jungjoon K. Lee
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract We present a novel genome-wide off-target prediction method named Extru-seq and compare it with cell-based (GUIDE-seq), in vitro (Digenome-seq), and in silico methods using promiscuous guide RNAs with large numbers of valid off-target sites.
Externí odkaz:
https://doaj.org/article/4edbb888a4dd403fbce800cf628179c6
Autor:
Sangjoon Lah, Segi Kim, In Kang, Cedric Hupperetz, Hyuncheol Jung, Hyeong Ryeol Choi, Young-Ho Lee, Hyeon-Ki Jang, Sangsu Bae, Chan Hyuk Kim
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background The incorporation of co-stimulatory signaling domains into second-generation chimeric antigen receptors (CARs) significantly enhances the proliferation and persistence of CAR-T cells in vivo, leading to successful clinical outcomes.Methods
Externí odkaz:
https://doaj.org/article/a35d5d39e36d48bf90ee77b9c9c01c1d
Autor:
Ju-Chan Park, Hyeon-Ki Jang, Jumee Kim, Jun Hee Han, Youngri Jung, Keuntae Kim, Sangsu Bae, Hyuk-Jin Cha
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 175-183 (2022)
Precise genome editing of human pluripotent stem cells (hPSCs) is crucial not only for basic science but also for biomedical applications such as ex vivo stem cell therapy and genetic disease modeling. However, hPSCs have unique cellular properties c
Externí odkaz:
https://doaj.org/article/12cceaa7458b4c7dae23f91eb622f072