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Picomole‐Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer
Autor:
Gontran Sangouard, Alessandro Zorzi, Yuteng Wu, Edouard Ehret, Mischa Schüttel, Sangram Kale, Cristina Díaz‐Perlas, Jonathan Vesin, Julien Bortoli Chapalay, Gerardo Turcatti, Christian Heinis
Publikováno v:
Angewandte Chemie International Edition. 60:21702-21707
Macrocyclic compounds are an attractive class of therapeutic ligands against challenging targets, such as protein-protein interactions. However, the development of macrocycles as drugs is hindered by the lack of large combinatorial macrocyclic librar