Zobrazeno 1 - 10 of 143 pro vyhledávání: '"Sangmook, Lee"'
1
Akademický článek
16p12.1 Deletion Orthologs are Expressed in Motile Neural Crest Cells and are Important for Regulating Craniofacial Development in Xenopus laevis
Autor: Micaela Lasser, Jessica Bolduc, Luke Murphy, Caroline O'Brien, Sangmook Lee, Santhosh Girirajan, Laura Anne Lowery
Publikováno v: Frontiers in Genetics, Vol 13 (2022)
Copy number variants (CNVs) associated with neurodevelopmental disorders are characterized by extensive phenotypic heterogeneity. In particular, one CNV was identified in a subset of children clinically diagnosed with intellectual disabilities (ID) t
Externí odkaz: https://doaj.org/article/5c5eb50256d544b88350b791cab466e7
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4
Akademický článek
Tau interferes with axonal neurite stabilization and cytoskeletal composition independently of its ability to associate with microtubules
Autor: Edward F. Boumil, Rishel B. Vohnoutka, Sangmook Lee, Thomas B. Shea
Publikováno v: Biology Open, Vol 9, Iss 9 (2020)
Tau impacts overall axonal transport particularly when overexpressed by interfering with translocation of kinesin along microtubules (MTs) and/or as a cargo of kinesin by outcompeting other kinesin cargo. To discern between which of these mechanisms
Externí odkaz: https://doaj.org/article/95de1b2af5fe49c89a0da9746ab8ca8f
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7
Akademický článek
Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis
Autor: Alexandra Mills, Elizabeth Bearce, Rachael Cella, Seung Woo Kim, Megan Selig, Sangmook Lee, Laura Anne Lowery
Publikováno v: Frontiers in Physiology, Vol 10 (2019)
Wolf-Hirschhorn Syndrome (WHS) is a human developmental disorder arising from a hemizygous perturbation, typically a microdeletion, on the short arm of chromosome four. In addition to pronounced intellectual disability, seizures, and delayed growth,
Externí odkaz: https://doaj.org/article/2b72e36242a843749feff2e9348d5e14
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9
Akademický článek
Assembly and turnover of neurofilaments in growing axonal neurites
Autor: Edward F. Boumil, Rishel Vohnoutka, Sangmook Lee, Harish Pant, Thomas B. Shea
Publikováno v: Biology Open, Vol 7, Iss 1 (2018)
Neurofilaments (NFs) are thought to provide stability to the axon. We examined NF dynamics within axonal neurites of NB2a/d1 neuroblastoma by transient transfection with green fluorescent protein-tagged NF-heavy (GFP-H) under the control of a tetracy
Externí odkaz: https://doaj.org/article/a6601704d68a4eb3a8df900f60642ad4
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10
Akademický článek
The high molecular weight neurofilament subunit plays an essential role in axonal outgrowth and stabilization
Autor: Sangmook Lee, Thomas B. Shea
Publikováno v: Biology Open, Vol 3, Iss 10, Pp 974-981 (2014)
Neurofilaments (NFs) are thought to provide structural support to mature axons via crosslinking of cytoskeletal elements mediated by the C-terminal region of the high molecular weight NF subunit (NF-H). Herein, we inhibited NF-H expression in differe
Externí odkaz: https://doaj.org/article/6eea094a09464b3c9501bd31ccd9093a
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