Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Sangjune Kim"'
Autor:
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 that facilitates the binding
Externí odkaz:
https://doaj.org/article/a51c0a5470e944f6b5b546f3fa48e34f
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Background In vitro disease modeling enables translational research by providing insight into disease pathophysiology and molecular mechanisms, leading to the development of novel therapeutics. Nevertheless, in vitro systems have limitations
Externí odkaz:
https://doaj.org/article/8b1331897aa947a7a5d5ea4789adae89
Autor:
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/59a521d03e984273bb3d708b36d570e9
Autor:
Jae-Hyun Jo, Jong-Uk Park, Yeong-Mu Kim, Seon-Mi Ok, Dong-Kyu Kim, Dong-Hyun Jung, Hye-Ji Kim, Hyun-A Seong, Hyo Je Cho, Jihoon Nah, Sangjune Kim, Haiqing Fu, Christophe E. Redon, Mirit I. Aladjem, Sang-Min Jang
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Megakaryocytes (MKs) are platelet precursors, which arise from hematopoietic stem cells (HSCs). While MK lineage commitment and differentiation are accompanied by changes in gene expression, many factors that modulate megakaryopoi
Externí odkaz:
https://doaj.org/article/491ba279b8ea4325a3b65829219d8458
Autor:
Saebom Lee, Hye Guk Ryu, Sin Ho Kweon, Hyerynn Kim, Hyeonwoo Park, Kyung-Ha Lee, Sang-Min Jang, Chan Hyun Na, Sangjune Kim, Han Seok Ko
Publikováno v:
Cells, Vol 11, Iss 24, p 3972 (2022)
Non-receptor tyrosine kinase, c-Abl plays a role in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease. Here, we found that TDP-43, which was one of the main proteins comprising pathologica
Externí odkaz:
https://doaj.org/article/52a7d62560b54061891c5a0f3f91c34e
Autor:
Seung Pil Yun, Donghoon Kim, Sangjune Kim, SangMin Kim, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Saebom Lee, Tae-In Kam, Suhyun Lee, Sangwoo Ham, Jae Hong Park, Valina L. Dawson, Ted M. Dawson, Yunjong Lee, Han Seok Ko
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-19 (2018)
Abstract Background Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB). Since both genetic and environmental factors contribute to the pa
Externí odkaz:
https://doaj.org/article/213271272ea14b04817b478ead2a71ae
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0207737 (2018)
ObjectivesThis study aims to investigate the differences in the utilisation of preventive health services among standard, nonstandard workers, the self-employed, and unpaid family workers.MethodsWe used the 4th and 5th Korea National Health and Nutri
Externí odkaz:
https://doaj.org/article/42e251f1f0924a31a6178b4bc82b39c9
Autor:
Seulah Choi, Donghoon Kim, Tae-In Kam, Seungpil Yun, Sangjune Kim, Hyejin Park, Heehong Hwang, Olga Pletnikova, Juan C Troncoso, Valina L Dawson, Ted M Dawson, Han Seok Ko
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143854 (2015)
Glucocerebrosidase (GCase) functions as a lysosomal enzyme and its mutations are known to be related to many neurodegenerative diseases, including Gaucher's disease (GD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). However, there i
Externí odkaz:
https://doaj.org/article/51fa112d70ee463591d8203cbdcdd344
Publikováno v:
Molecules & Cells (Elsevier B.V); Aug2024, Vol. 47 Issue 8, p1-9, 9p
Autor:
Yeong-Mu Kim, Hye-Ji Kim, Dong-Kyu Kim, Dong-Hyun Jung, Hyo Je Cho, Sangjune Kim, Jihoon Nah, Sang-Min Jang
Publikováno v:
Biochemical and Biophysical Research Communications. 637:341-347
Cullin-RING E3 ubiquitin ligases (CRLs) spatiotemporally regulate the proteasomal degradation of numerous cellular proteins involved in cell cycle control, DNA replication, and maintenance of genome stability. Activation of CRLs is controlled via ned