Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sangita Bhaker"'
Autor:
Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. Object
Externí odkaz:
https://doaj.org/article/b98b2138b6a345bba5e4c156f9115f19
Autor:
Sangita Bhaker, Michael A. Portelli, Kamini Rakkar, Dominick Shaw, Simon Johnson, Christopher Brightling, Ian Sayers
Publikováno v:
ERJ Open Research, Vol 8, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/ddb2c536e99642c9b3bab43b9ceb0b9b
Autor:
Amanda P. Henry, Kelly Probert, Ceri E. Stewart, Dhruma Thakker, Sangita Bhaker, Sheyda Azimi, Ian P. Hall, Ian Sayers
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a candidate causal gene in this l
Externí odkaz:
https://doaj.org/article/45b95aff7d3b48fb89b56781600c8437
Autor:
Jonathan O'Loughlin, Robert J. Hall, Sangita Bhaker, Michael A. Portelli, Amanda Henry, Vincent Pang, David O. Bates, Tyson V. Sharp, Ian Sayers
Publikováno v:
ERJ Open Research, Vol 7, Iss 1 (2021)
Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs) isolat
Externí odkaz:
https://doaj.org/article/3c3cfae19b254f35bbc5345f4b26032c
Autor:
Tracy L Rimington, Emily Hodge, Charlotte K Billington, Sangita Bhaker, Binaya K C, Iain Kilty, Scott Jelinsky, Ian P Hall, Ian Sayers
Publikováno v:
F1000Research, Vol 6 (2017)
Background: Airway inflammation is a feature of many respiratory diseases and there is a need for newer, more effective anti-inflammatory compounds. The aim of this study was to develop an ex vivo human lung explant model which can be used to help st
Externí odkaz:
https://doaj.org/article/2beaa65a72814bba8b062eba6979408a
Autor:
Sangita Bhaker, Michael A. Portelli, Robert J. Hall, David O. Bates, Ian Sayers, Vincent Pang, Amanda P. Henry, Tyson V. Sharp, Jonathan O'Loughlin
Publikováno v:
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 1 (2021)
Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HBECs) isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53953e0e0f992d83fd7833e8a371fb54
https://doi.org/10.1183/23120541.00254-2020
https://doi.org/10.1183/23120541.00254-2020
Autor:
David O. Bates, Vincent Pang, Judith M. Vonk, Charlote K. Billington, John W. Holloway, Sangita Bhaker, Cornelis J. Vermeulen, Don D. Sin, Ian Sayers, Martin D. Tobin, Peter H. Howarth, F. Nicole Dijk, David C. Nickle, Ian P. Hall, Yohan Bossé, Louise V. Wain, Dominick E. Shaw, John D Blakey, Andrew M. Fogarty, Amisha Singapuri, Michael A. Portelli, Martijn C. Nawijn, Cheng J. Xu, Andrew V. Benest, Ma'en Obeidat, Liam G Heaney, Jenny Hankinson, Maarten van den Berge, Rekha Chaudhuri, Angela Simpson, Tricia M. McKeever, Simon R. Johnson, Adel H. Mansur, Robert Niven, Zara Pogson, Gabrielle A. Lockett, Christopher E. Brightling, Amanda P. Henry, Neil C. Thomson, Nick Shrine, Gerard H. Koppelman, Maria Ketelaar, Alen Faiz
Publikováno v:
Journal of Allergy and Clinical Immunology, 147(1), 144-157. MOSBY-ELSEVIER
Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevated in sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2e19b5c3a77f7d0087040f985a7c81
https://doi.org/10.1016/j.jaci.2020.04.051
https://doi.org/10.1016/j.jaci.2020.04.051
Autor:
Sangita Bhaker, Michael A. Portelli, Kamini Rakkar, Dominick Shaw, Simon Johnson, Christopher Brightling, Ian Sayers
Publikováno v:
ERJ open research. 8(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b45556b835478b5e7a9e31109b16444
https://pubmed.ncbi.nlm.nih.gov/35198626
https://pubmed.ncbi.nlm.nih.gov/35198626
Extended Lifespan Bronchial Epithelial Cells Maintain Cellular Phenotype and Transcriptome Integrity
Autor:
Sangita Bhaker, David O. Bates, Tyson V. Sharp, Michael A. Portelli, Amanda P. Henry, Vincent Pang, Robert J. Hall, J. O'Loughlin, Ian Sayers
Publikováno v:
A65. EPITHELIAL CELL BIOLOGY: THE PLOT THICKENS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::108ff38396a8b88cc3fa15edbcca4938
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2298
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2298
Autor:
Charlotte K. Billington, Gerard H. Koppelman, Liam G Heaney, Adel H. Mansur, Jenny Hankinson, Martijn C. Nawijn, Corry-Anke Brandsma, Sangita Bhaker, Andrew M. Fogarty, Dominick E. Shaw, Michael A. Portelli, Cornelis J. Vermeulen, Judith M. Vonk, Nick Shrine, Amanda P. Henry, Ian Sayers, Yohan Bossé, Maria Ketelaar, Martin D. Tobin, Peter H. Howarth, David C. Nickle, Néomi S. Grotenboer, Ma'en Obeidat, Gabrielle A. Lockett, John W. Holloway, Christopher E. Brightling, Alen Faiz, Rekha Chaudhuri, Tricia M. McKeever, Simon R. Johnson, Paul de Vos, Dirkje S. Postma, Zara Pogson, Neil C. Thomson, Sharon Brouwer, Maarten van den Berge, Angela Simpson, Amisha Singapuri, Robert Niven, F. Nicole Dijk, Ian P. Hall, Louise V. Wain, John D Blakey
Publikováno v:
Portelli, M A, Dijk, F N, Ketelaar, M E, Shrine, N, Hankinson, J, Bhaker, S, Grotenboer, N S, Obeidat, M, Henry, A P, Billington, C K, Shaw, D, Johnson, S R, Pogson, Z E, Fogarty, A, McKeever, T M, Nickle, D C, Bossé, Y, van den Berge, M, Faiz, A, Brouwer, S, Vonk, J M, de Vos, P, Brandsma, C-A, Vermeulen, C J, Singapuri, A, Heaney, L G, Mansur, A H, Chaudhuri, R, Thomson, N C, Holloway, J W, Lockett, G A, Howarth, P H, Niven, R, Simpson, A, Blakey, J D, Tobin, M D, Postma, D S, Hall, I P, Wain, L V, Nawijn, M C, Brightling, C E, Koppelman, G H & Sayers, I 2020, ' Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium ', JCI insight, vol. 5, no. 8, pp. 1-19 . https://doi.org/10.1172/jci.insight.132446
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INC
JCI Insight
JCI Insight, 5(8):132446. AMER SOC CLINICAL INVESTIGATION INC
The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35eec0d3bd47361ef723e102569f7099
https://doi.org/10.1172/jci.insight.132446
https://doi.org/10.1172/jci.insight.132446