Quantitative Prediction of Human Pharmacokinetics and Pharmacodynamics of CKD519, a Potent Inhibitor of Cholesteryl Ester Transfer Protein (CETP)

Autor: Suein Choi, Seunghoon Han, Sangil Jeon, Dong-Seok Yim

Publikováno v: Pharmaceutics, Vol 11, Iss 7, p 336 (2019)

CKD519, a selective inhibitor of cholesteryl ester transfer protein(CETP), is undergoing development as an oral agent for the treatment of primary hypercholesterolemia and mixed hyperlipidemia. The aim of this study was to predict the appropriate eff

Externí odkaz: https://doaj.org/article/1a5302f7a2ed4f95a613b8550172d346

An experience on the model-based evaluation of pharmacokinetic drug-drug interaction for a long half-life drug

Autor: Seunghoon Han, Maria Park, Sungpil Han, Sangil Jeon, Suein Choi, Yunjung Hong

Publikováno v: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology

Fixed-dose combinations development requires pharmacokinetic drug-drug interaction (DDI) studies between active ingredients. For some drugs, pharmacokinetic properties such as long half-life or delayed distribution, make it difficult to conduct such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9d3fcefc2051cf48b064efdc322460
https://doi.org/10.4196/kjpp.2021.25.6.545

Population pharmacokinetic analysis of metformin administered as fixed-dose combination in Korean healthy adults.

Autor: Suein Choi^1,2, Sangil Jeon³, Seunghoon Han^1,4 waystolove@catholic.ac.kr

Publikováno v: Translational & Clinical Pharmacology. 2018, Vol. 26 Issue 1, p25-31. 7p.

Physiologically-based pharmacokinetic predictions of intestinal BCRP-mediated drug interactions of rosuvastatin in Koreans

Autor: Wan-Su Park, Taegon Hong, Soo Hyeon Bae, Gab-jin Park, Dong-Seok Yim, Sangil Jeon, Jongtae Lee, Seunghoon Han

Publikováno v: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology

It was recently reported that the Cmax and AUC of rosuvastatin increases when it is coadministered with telmisartan and cyclosporine. Rosuvastatin is known to be a substrate of OATP1B1, OATP1B3, NTCP, and BCRP transporters. The aim of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f888cfd1828139d2a36705940ae9e3
http://europepmc.org/articles/PMC5928345

Comparison of oral absorption models for pregabalin: usefulness of transit compartment model

Autor: Dong-Seok Yim, Sangil Jeon, Jongtae Lee, Seunghoon Han, Taegon Hong

Publikováno v: Drug Design, Development and Therapy

Taegon Hong,1 Seunghoon Han,2,3 Jongtae Lee,2,3 Sangil Jeon,4 Dong-Seok Yim2,3 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, 2Department of Clinical Pharmacology and Therapeutics, Seoul St Mary’s H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb2f5533b25eda98bf9524e4c4482eb
https://doi.org/10.2147/dddt.s123318