What does not kill you makes you stronger? Effects of paternal age at conception on fathers and sons.

Autor: Sanghvi K; Department of Biology, University of Oxford, Oxford, United Kingdom., Pizzari T; Department of Biology, University of Oxford, Oxford, United Kingdom., Sepil I; Department of Biology, University of Oxford, Oxford, United Kingdom.

Publikováno v: Evolution; international journal of organic evolution [Evolution] 2024 Sep 03; Vol. 78 (9), pp. 1619-1632.

Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure 6 Months After Medication Escalation: The RADIANCE Clinical Trial Program.

Autor: Azizi M; Université Paris Cité, France (M.A.).; AP-HP, Hôpital Européen Georges-Pompidou, Hypertension Department and DMU CARTE, Paris, France (M.A.).; INSERM, Paris, France (M.A.)., Sharp ASP; University Hospital of Wales and Cardiff University, Cardiff, UK (A.S.P.S.)., Fisher NDL; The Brigham and Women's Hospital, Boston, MA (N.D.L.F.)., Weber MA; Division of Cardiovascular Medicine, State University of New York, Downstate Medical Center, New York (M.A.W., M.S.)., Lobo MD; Barts NIHR Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, UK (M.D.L.)., Daemen J; Department of Cardiology, Erasmus University Medical Center Rotterdam, the Netherlands (J.D.)., Lurz P; Zentrum für Kardiologie, Universitätsmedizin Mainz, Germany (P.L.)., Mahfoud F; Klinik für Innere Medizin III, Saarland University Hospital, Homburg/Saar, Germany (F.M.).; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge (F.M.)., Schmieder RE; Nephrology and Hypertension, University Hospital Erlangen, Friedrich Alexander University, Erlangen, Germany (R.E.S.)., Basile J; Division of Cardiovascular Medicine, Medical University of South Carolina, Ralph H. Johnson VA Medical Center, Charleston (J.B.)., Bloch MJ; Department of Medicine, University of Nevada School of Medicine, Vascular Care, Renown Institute of Heart and Vascular Health, Reno (M.J.B.)., Saxena M; Division of Cardiovascular Medicine, State University of New York, Downstate Medical Center, New York (M.A.W., M.S.)., Wang Y; Minneapolis Heart Institute, Abbott Northwestern Hospital, MN (Y.W.)., Sanghvi K; Deborah Heart & Lung Center, Brown Mills, NJ (K.S.)., Jenkins JS; Ochsner Medical Center, New Orleans, LA (J.S.J.)., Devireddy C; Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA (C.D.)., Rader F; Cedars-Sinai Heart Institute, Los Angeles, CA (F.R.)., Gosse P; Hôpital Saint-André-CHU, Bordeaux, France (P.G.)., Claude L; Recor Medical, Inc., Palo Alto, CA (L.C., D.A.A.)., Augustin DA; Recor Medical, Inc., Palo Alto, CA (L.C., D.A.A.)., McClure CK; NAMSA, Minneapolis, MN (C.K.M.)., Kirtane AJ; Columbia University Irving Medical Center/New York-Presbyterian Hospital and the Cardiovascular Research Foundation, New York, NY (A.J.K.).

Publikováno v: Circulation [Circulation] 2024 Mar 05; Vol. 149 (10), pp. 747-759. Date of Electronic Publication: 2023 Oct 26.

Comprehensive molecular phenotyping of ARID1A -deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.

Autor: Xu C; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Law JH; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chua JS; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Sheng T; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Flores NM; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Pizzi MP; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Okabe A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Zhu F; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Kumar V; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lu X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Benitez AM; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Lian BSX; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ma H; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ho SWT; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Ramnarayanan K; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Anene-Nzelu CG; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.; Montreal Heart Institute, Quebec, Québec, Canada.; Department of Medicine, University of Montreal, Quebec, Québec, Canada., Razavi-Mohseni M; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Baltimore, Maryland, USA., Abdul Ghani SAB; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tay ST; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lee MH; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Guo YA; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Ashktorab H; Department of Medicine, Howard University, Washington, DC, USA., Smoot D; Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA., Li S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Skanderup AJ; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Beer MA; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Baltimore, Maryland, USA., Foo RSY; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Wong JSH; Department of General Surgery, Tan Tock Seng Hospital, Singapore., Sanghvi K; Department of General Surgery, Tan Tock Seng Hospital, Singapore., Yong WP; Department of Haematology-Oncology, National University Health System, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Sundar R; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore.; The N.1 Institute for Health, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore., Kaneda A; Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan., Prabhakar S; Computational and Systems Biology, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore., Mazur PK; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Ajani JA; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Yeoh KG; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Gastroenterology and Hepatology, National University Health System, Singapore., So JB; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.; Singapore Gastric Cancer Consortium, Singapore.; Division of Surgical Oncology, National University Cancer Institute, Singapore., Tan P; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore gmstanp@duke-nus.edu.sg sursbyj@nus.edu.sg chang.xu@duke-nus.edu.sg.; Epigenetic and Epigenomic Regulation, Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore.

Publikováno v: Gut [Gut] 2023 Sep; Vol. 72 (9), pp. 1651-1663. Date of Electronic Publication: 2023 Mar 14.

Multiancestry genomic and transcriptomic analysis of gastric cancer.

Autor: Totoki Y; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan., Saito-Adachi M; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan., Shiraishi Y; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan., Komura D; Department of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Nakamura H; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan., Suzuki A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Tatsuno K; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Rokutan H; Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Hama N; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan., Yamamoto S; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Ono H; Division of Bioinformatics, National Cancer Center Research Institute, Tokyo, Japan., Arai Y; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan., Hosoda F; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan., Katoh H; Department of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Chiba K; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan., Iida N; Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan., Nagae G; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Ueda H; Biological Data Science, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Shihang C; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Sekine S; Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan., Abe H; Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Nomura S; Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Matsuura T; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan., Sakai E; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan., Ohshima T; Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Kanagawa, Japan., Rino Y; Department of Surgery, Yokohama City University Graduate School of Medicine, Kanagawa, Japan., Yeoh KG; Dept of Medicine, National University of Singapore, Singapore, Singapore., So J; Dept of Surgery, National University of Singapore, Singapore, Singapore., Sanghvi K; Dept of Surgery, Tan Tock Seng Hospital, Singapore, Singapore., Soong R; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Fukagawa A; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan., Yachida S; Department of Cancer Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.; Division of Genomic Medicine, National Cancer Center Research Institute, Tokyo, Japan., Kato M; Division of Bioinformatics, National Cancer Center Research Institute, Tokyo, Japan., Seto Y; Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Ushiku T; Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Nakajima A; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan., Katai H; Department of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan., Tan P; Cancer and Stem Cell Biology, Duke-NUS Medical School Singapore, Singapore, Singapore.; Epigenomic and Epitranscriptomic Regulation, Genome Institute of Singapore, Singapore, Singapore., Ishikawa S; Department of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Aburatani H; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Shibata T; Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan. tshibata@ims.u-tokyo.ac.jp.; Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. tshibata@ims.u-tokyo.ac.jp.

Publikováno v: Nature genetics [Nat Genet] 2023 Apr; Vol. 55 (4), pp. 581-594. Date of Electronic Publication: 2023 Mar 13.

MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors.

Autor: Kilian M; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurology, MCTN, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Sheinin R; Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Blavatnik School of Computer Science, Tel Aviv University, 69978 Tel Aviv, Israel., Tan CL; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurology, MCTN, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Friedrich M; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany; Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany., Krämer C; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Kaminitz A; Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Sanghvi K; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurology, MCTN, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Lindner K; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany; Immune Monitoring Unit, National Center for Tumor Diseases (NCT), Heidelberg, Germany., Chih YC; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurology, MCTN, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Cichon F; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Joint Immunotherapeutics Laboratory of the DKFZ-Bayer Innovation Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany., Richter B; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Jung S; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Jähne K; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ratliff M; Department of Neurosurgery, University Hospital Mannheim, Mannheim, Germany., Prins RM; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Etminan N; Department of Neurosurgery, University Hospital Mannheim, Mannheim, Germany., von Deimling A; DKTK CCU Neuropathology, DKFZ, Heidelberg, Germany; Department of Neuropathology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany., Wick W; Neurology Clinic, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany; DKTK CCU Neurooncology, DKFZ, Heidelberg, Germany., Madi A; Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: asafmadi@tauex.tau.ac.il., Bunse L; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurology, MCTN, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address: l.bunse@dkfz.de., Platten M; DKTK Clinical Cooperation Unit (CCU) Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurology, MCTN, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Immune Monitoring Unit, National Center for Tumor Diseases (NCT), Heidelberg, Germany; Helmholtz Institute of Translational Oncology (HI-TRON), Mainz, Germany; DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim, Germany. Electronic address: m.platten@dkfz.de.

Publikováno v: Cancer cell [Cancer Cell] 2023 Feb 13; Vol. 41 (2), pp. 235-251.e9. Date of Electronic Publication: 2023 Jan 12.