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Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen–glucose deprivation-induced apoptosis in primary rat cortical neuronal cells

Autor: Sanghee Seo, Seungjoon Park, Minho Moon, Hyunju Chung

Publikováno v: Journal of Endocrinology. 198:511-521

Only acylated ghrelin (AG) binds GH secretagog receptor 1a (GHS-R1a) and has central endocrine activities. An anti-apoptotic effect of AG in neuronal cells has recently been reported. However, whether there is a neuroprotective effect of unacylated g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb165b74550ec8e7c8f484e38acfdae2
https://doi.org/10.1677/joe-08-0160

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Ghrelin Inhibits Apoptosis in Hypothalamic Neuronal Cells during Oxygen-Glucose Deprivation

Autor: Seungjoon Park, Hyunju Chung, Sunghee Ju, Eunhee Kim, Dahm Lee, Hocheol Kim, Dae Hee Lee, Sanghee Seo

Publikováno v: Endocrinology. 148:148-159

Ghrelin is an endogenous ligand for the GH secretagogue receptor, produced and secreted mainly from the stomach. Ghrelin stimulates GH release and induces positive energy balances. Previous studies have reported that ghrelin inhibits apoptosis in sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6645ce51a0236ede338908fbbc76be11
https://doi.org/10.1210/en.2006-0991

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Role of Glucocorticoids in Fasting-induced Changes in Hypothalamic and Pituitary Components of the Growth Hormone (GH)-axis

Autor: Hyunju Chung, Seungjoon Park, Eunhee Kim, Sanghee Seo

Publikováno v: The Korean journal of physiologypharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 12(5)

To directly test if elevated glucocorticoids are required for fasting-induced regulation of growth hormone (GH)-releasing hormone (GHRH), GHRH receptors (GHRH-R) and ghrelin receptors (GHS-R) expression, male rats were bilaterally adrenalectomized or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87efd50910f72bffe4218dfec21f4f38
https://pubmed.ncbi.nlm.nih.gov/19967059

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Acute effects of glucagon-like peptide-1 on hypothalamic neuropeptide and AMP activated kinase expression in fasted rats

Autor: Dahm Lee, Hyunju Chung, Seungjoon Park, Sanghee Seo, Sunghee Ju

Publikováno v: Endocrine journal. 55(5)

Intracerebroventricular (icv) administration of glucagon-like peptide-1 (GLP-1) inhibits food intake and induces c-fos expression in the hypothalamus. However, the effects of GLP-1 on hypothalamic neuronal activity or neuropeptide mRNA expression are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c28bb0bfa7291af9a40dc8a7ec54ba
https://pubmed.ncbi.nlm.nih.gov/18506089

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IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4

Autor: Minho Moon, Sanghee Seo, Hyunju Chung, Seungjoon Park

Publikováno v: The Journal of endocrinology. 194(1)

The neuronal damage caused by ischemic brain injury is associated with increased apoptosis. IGF-I exposure promotes neuronal defense and survival against ischemic insult by inhibiting apoptotic processes. We investigated the role of prostate apoptosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e912514acf6663c7004808f9b2a316
https://pubmed.ncbi.nlm.nih.gov/17592023

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Protective effects of ghrelin in hypothalamic neuronal cells exposed to ischemic injury

Autor: Dahm Lee, Sanghee Seo, Hyunju Chung, Sunghee Ju, Seungjoon Park, Eunhee Kim

Publikováno v: Frontiers in Neuroendocrinology. 27:113-114

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::848a19d408b39f217fdc3569e82d45a5
https://doi.org/10.1016/j.yfrne.2006.03.294

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