Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Sanghee Cho"'
Autor:
Ru M. Wen, Zhengyuan Qiu, G. Edward W. Marti, Eric E. Peterson, Fernando Jose Garcia Marques, Abel Bermudez, Yi Wei, Rosalie Nolley, Nathan Lam, Alex LaPat Polasko, Chun-Lung Chiu, Dalin Zhang, Sanghee Cho, Grigorios Marios Karageorgos, Elizabeth McDonough, Chrystal Chadwick, Fiona Ginty, Kyeong Joo Jung, Raghu Machiraju, Parag Mallick, Laura Crowley, Jonathan R. Pollack, Hongjuan Zhao, Sharon J. Pitteri, James D. Brooks
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Loss of AZGP1 expression is a biomarker associated with progression to castration resistance, development of metastasis, and poor disease-specific survival in prostate cancer. However, high expression of AZGP1 cells in prostate ca
Externí odkaz:
https://doaj.org/article/5a28bfe2f761406aa6383b764b9fb5d0
Autor:
Deborah A McNamara, Jinru Shia, John P Burke, Manuela Salvucci, Daniel B Longley, Fiona Ginty, Andreas Lindner, Sanghee Cho, Elizabeth McDonough, John Graf, Canan Firat, Nil Urganci, Christine Surrette, Anna Matveeva, Batuhan Kisakol, Anthony O’Grady, Mohammadreza Azimi, Simon McDade, Jochen HM Prehn
Publikováno v:
BMJ Oncology, Vol 3, Iss 1 (2024)
Objective Inducing tumour cell apoptosis is a primary objective of chemotherapy but, to date, there are no validated biomarkers of apoptosis sensitivity or resistance. Our objective was to image multiple apoptosis pathway proteins at single cell leve
Externí odkaz:
https://doaj.org/article/59942d4fee7b4e8199fc8767f377b824
Autor:
Grigorios M. Karageorgos, Sanghee Cho, Elizabeth McDonough, Chrystal Chadwick, Soumya Ghose, Jonathan Owens, Kyeong Joo Jung, Raghu Machiraju, Robert West, James D. Brooks, Parag Mallick, Fiona Ginty
Publikováno v:
Frontiers in Bioinformatics, Vol 3 (2024)
Introduction: Prostate cancer is a highly heterogeneous disease, presenting varying levels of aggressiveness and response to treatment. Angiogenesis is one of the hallmarks of cancer, providing oxygen and nutrient supply to tumors. Micro vessel densi
Externí odkaz:
https://doaj.org/article/76f90f0b38a84f9db5dcbdb0a5e42308
Autor:
Soumya Ghose, Yingnan Ju, Elizabeth McDonough, Jonhan Ho, Arivarasan Karunamurthy, Chrystal Chadwick, Sanghee Cho, Rachel Rose, Alex Corwin, Christine Surrette, Jessica Martinez, Eric Williams, Anup Sood, Yousef Al-Kofahi, Louis D. Falo, Katy Börner, Fiona Ginty
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Mapping the human body at single cell resolution in three dimensions (3D) is important for understanding cellular interactions in context of tissue and organ organization. 2D spatial cell analysis in a single tissue section may be limited by
Externí odkaz:
https://doaj.org/article/2276dc28bd0e4da6bfbc5a405257e9d8
Autor:
Yun Jin Park, Jong Beom Heo, Yoon-Jung Choi, Sanghee Cho, Taeho Lee, Gyu Yong Song, Jong-Sup Bae
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2976 (2024)
High mobility group box 1 (HMGB1), a protein with important functions, has been recognized as a potential therapeutic target for the treatment of sepsis. One possible mechanism for this is that inhibiting HMGB1 secretion can exert antiseptic effects,
Externí odkaz:
https://doaj.org/article/a1e92ad1653d4def80d46f67711dbfb8
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gundaz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor sign
Externí odkaz:
https://doaj.org/article/685f337608c24440b7e084866104173a
Autor:
Emer O’Connell, Ian S. Reynolds, Andreas U. Lindner, Manuela Salvucci, Tony O’Grady, Orna Bacon, Sanghee Cho, Elizabeth McDonough, Daniel Longley, Fiona Ginty, Deborah A. McNamara, John P. Burke, Jochen H. M. Prehn
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundMucinous colorectal cancer (CRC) represents 10% of all CRC and is associated with chemotherapy resistance. This study aimed to determine expression of apoptosis and necroptosis mediators in mucinous CRC.MethodsRNA gene expression data were
Externí odkaz:
https://doaj.org/article/24053e31c1834f909ac0a7c4bff31715
Autor:
Soumya Ghose, Sanghee Cho, Fiona Ginty, Elizabeth McDonough, Cynthia Davis, Zhanpan Zhang, Jhimli Mitra, Adrian L. Harris, Aye Aye Thike, Puay Hoon Tan, Yesim Gökmen-Polar, Sunil S. Badve
Publikováno v:
Cancers, Vol 15, Iss 7, p 1922 (2023)
Standard clinicopathological parameters (age, growth pattern, tumor size, margin status, and grade) have been shown to have limited value in predicting recurrence in ductal carcinoma in situ (DCIS) patients. Early and accurate recurrence prediction w
Externí odkaz:
https://doaj.org/article/c4183dab9f604c55b311eb5f6ab0625f
Autor:
Dustin J. Flanagan, Raheleh Amirkhah, David F. Vincent, Nuray Gunduz, Pauline Gentaz, Patrizia Cammareri, Aoife J. McCooey, Amy M. B. McCorry, Natalie C. Fisher, Hayley L. Davis, Rachel A. Ridgway, Jeroen Lohuis, Joshua D. G. Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K. Markert, Douglas Strathdee, Laurent Bartholin, Keara L. Redmond, Emma M. Kerr, Daniel B. Longley, Fiona Ginty, Sanghee Cho, Helen G. Coleman, Maurice B. Loughrey, Alberto Bardelli, Timothy S. Maughan, Andrew D. Campbell, Mark Lawler, Simon J. Leedham, Simon T. Barry, Gareth J. Inman, Jacco van Rheenen, Philip D. Dunne, Owen J. Sansom
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d890b609d092453794d4b110a230e27b
Autor:
Sunil S. Badve, Sanghee Cho, Xiaoyu Lu, Sha Cao, Soumya Ghose, Aye Aye Thike, Puay Hoon Tan, Idris Tolgay Ocal, Daniele Generali, Fabrizio Zanconati, Adrian L. Harris, Fiona Ginty, Yesim Gökmen-Polar
Publikováno v:
Cancers, Vol 14, Iss 16, p 3916 (2022)
Tumor-infiltrating lymphocytes (TILs) are prognostic in invasive breast cancer. However, their prognostic significance in ductal carcinoma in situ (DCIS) has been controversial. To investigate the prognostic role of TILs in DCIS outcome, we used diff
Externí odkaz:
https://doaj.org/article/8a657860535842f4bad7ebfbd7a7ff3a