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The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1

Autor: Twelvetrees, Alison E., Pernigo, Stefano, Sanger, Anneri, Guedes-Dias, Pedro, Schiavo, Giampietro, Steiner, Roberto A., Dodding, Mark P., Holzbaur, Erika L.F.

Publikováno v: In Neuron 1 June 2016 90(5):1000-1015

Folliculin directs the formation of a Rab34–RILP complex to control the nutrient‐dependent dynamic distribution of lysosomes

Autor: Starling, Georgina P, Yip, Yan Y, Sanger, Anneri, Morton, Penny E, Eden, Emily R, Dodding, Mark P

Publikováno v: EMBO Reports
Starling, G P, Yip, Y Y, Sanger, A, Morton, P E, Eden, E R & Dodding, M P 2016, ' Folliculin directs the formation of a Rab34-RILP complex to control the nutrient-dependent dynamic distribution of lysosomes ', EMBO Reports, vol. 17, no. 6, pp. 823-841 . https://doi.org/10.15252/embr.201541382

The spatial distribution of lysosomes is important for their function and is, in part, controlled by cellular nutrient status. Here, we show that the lysosome associated Birt–Hoge–Dubé (BHD) syndrome renal tumour suppressor folliculin (FLCN) reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cbd6921d313dc7ac5fa24861d5109de6
http://europepmc.org/articles/PMC4893818

SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain

Autor: Sanger, Anneri, Yip, Yan Y., Randall, Thomas S., Pernigo, Stefano, Steiner, Roberto A., Dodding, Mark P.

Publikováno v: Journal of Cell Science
Sanger, A, Yip, Y Y, Randall, T S, Pernigo, S, Steiner, R A & Dodding, M P 2017, ' SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain-binding domain ', Journal of Cell Science, vol. 130, no. 9, pp. 1637-1651 . https://doi.org/10.1242/jcs.198267
Sanger, A, Yip, Y Y, Randall, T S, Pernigo, S, Steiner, R A & Dodding, M P 2017, ' SKIP controls lysosome positioning using a composite kinesin-1 heavy and light chain binding domain ', Journal of cell science, vol. 130, no. 9, pp. 1637-1651 . https://doi.org/10.1242/jcs.198267

The molecular interplay between cargo recognition and regulation of the activity of the kinesin-1 microtubule motor is not well understood. Using the lysosome adaptor SKIP (also known as PLEKHM2) as model cargo, we show that the kinesin heavy chains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::67893788becae641830b51e7a721e444
http://hdl.handle.net/11577/3403010