Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Sangeeta S Chavan"'
Autor:
Aisling Tynan, Téa Tsaava, Manojkumar Gunasekaran, Carlos E. Bravo Iñiguez, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Publikováno v:
Bioelectronic Medicine, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background Key to the advancement of the field of bioelectronic medicine is the identification of novel pathways of neural regulation of immune function. Sensory neurons (termed nociceptors) recognize harmful stimuli and initiate a protectiv
Externí odkaz:
https://doaj.org/article/1343afe18bba44f98cfdd995b1bea836
Autor:
Dane A. Thompson, Tea Tsaava, Arvind Rishi, Sam J. George, Tyler D. Hepler, Daniel Hide, Valentin A. Pavlov, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-10 (2023)
Abstract Background Acute pancreatitis is a common and serious inflammatory condition currently lacking disease modifying therapy. The cholinergic anti-inflammatory pathway (CAP) is a potent protective anti-inflammatory response activated by vagus ne
Externí odkaz:
https://doaj.org/article/637ce3daf8364f509c994bd8ab365cf4
Autor:
Ashti M. Shah, Ruben Zamora, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Meghan Addorisio, Tea Tsaava, Aisling Tynan, Kevin Tracey, Sangeeta S. Chavan, Yoram Vodovotz
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
Introduction: The vagus nerve innervates multiple organs, but its role in regulating cross-tissue spread of inflammation is as yet unclear. We hypothesized that the vagus nerve may regulate cross-tissue inflammation via modulation of the putatively n
Externí odkaz:
https://doaj.org/article/496c8d0e4a73410d9d08b91bf0ee8b3b
Autor:
Carlos E. Bravo-Iñiguez, Jason R. Fritz, Shilpa Shukla, Susmita Sarangi, Dane A. Thompson, Seema G. Amin, Tea Tsaava, Saher Chaudhry, Sara P. Valentino, Hannah B. Hoffman, Catherine W. Imossi, Meghan E. Addorisio, Sergio I. Valdes-Ferrer, Sangeeta S. Chavan, Lionel Blanc, Christopher J. Czura, Kevin J. Tracey, Jared M. Huston
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Deficiency of coagulation factor VIII in hemophilia A disrupts clotting and prolongs bleeding. While the current mainstay of therapy is infusion of factor VIII concentrates, inhibitor antibodies often render these ineffective. Because precli
Externí odkaz:
https://doaj.org/article/067fc7beffb44e5298ec3b3aee8105af
Autor:
Stavros Zanos, Despoina Ntiloudi, John Pellerito, Richard Ramdeo, John Graf, Kirk Wallace, Victoria Cotero, Jeff Ashe, Jessica Moon, Meghan Addorisio, David Shoudy, Thomas R. Coleman, Michael Brines, Chris Puleo, Kevin J. Tracey, Sangeeta S. Chavan
Publikováno v:
Brain Stimulation, Vol 16, Iss 3, Pp 703-711 (2023)
Focused ultrasound stimulation (FUS) activates mechanosensitive ion channels and is emerging as a method of noninvasive neuromodulation. In preclinical studies, FUS of the spleen (sFUS) activates an anti-inflammatory neural pathway which suppresses a
Externí odkaz:
https://doaj.org/article/be0515c41a95436fa5b189fda07edc16
Autor:
Dane A. Thompson, Tea Tsaava, Arvind Rishi, Sam J. George, Tyler D. Hepler, Daniel Hide, Valentin A. Pavlov, Michael Brines, Sangeeta S. Chavan, Kevin J. Tracey
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/eb9da11fbff64479978163f9c17e973d
Autor:
Harold A. Silverman, Aisling Tynan, Tyler D. Hepler, Eric H. Chang, Manojkumar Gunasekaran, Jian Hua Li, Tomás S. Huerta, Tea Tsaava, Qing Chang, Meghan E. Addorisio, Adrian C. Chen, Dane A. Thompson, Valentin A. Pavlov, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-15 (2023)
Abstract Background Inflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β) and other cytokines produced during inflammatory responses activate sensory neurons (noci
Externí odkaz:
https://doaj.org/article/371e534ad34c4f0f8c84b787b0e56ebe
Autor:
Santhoshi P. Palandira, Joseph Carrion, Lauren Turecki, Aidan Falvey, Qiong Zeng, Hui Liu, Tea Tsaava, Dov Herschberg, Michael Brines, Sangeeta S. Chavan, Eric H. Chang, An Vo, Yilong Ma, Christine N. Metz, Yousef Al-Abed, Kevin J. Tracey, Valentin A. Pavlov
Publikováno v:
Bioelectronic Medicine, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Background Brain metabolic alterations and neuroinflammation have been reported in several peripheral inflammatory conditions and present significant potential for targeting with new diagnostic approaches and treatments. However, non-invasiv
Externí odkaz:
https://doaj.org/article/f6eb8380ba334652af35af0a18d0e5a6
Autor:
Huan Yang, Timir Datta-Chaudhuri, Sam J. George, Bilal Haider, Jason Wong, Tyler D. Hepler, Ulf Andersson, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Publikováno v:
Bioelectronic Medicine, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Background Neuroinflammation is an important driver of acute and chronic pain states. Therefore, targeting molecular mediators of neuroinflammation may present an opportunity for developing novel pain therapies. In preclinical models of neur
Externí odkaz:
https://doaj.org/article/3866357a2d90406daa54cc9fdd83e33f
Autor:
Dane A. Thompson, Tea Tsaava, Arvind Rishi, Sandeep Nadella, Lopa Mishra, David A. Tuveson, Valentin A. Pavlov, Michael Brines, Kevin J. Tracey, Sangeeta S. Chavan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionInflammation is an inherently self-amplifying process, resulting in progressive tissue damage when unresolved. A brake on this positive feedback system is provided by the nervous system which has evolved to detect inflammatory signals and
Externí odkaz:
https://doaj.org/article/53f01de90ba54c5f84c8e02d0440fff9