Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sangeeta Jayakar"'
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Supplementary figure 3 shows H3K27 acetylation ChIPseq QC analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477ddd9560eda30f5c026406d5682a9e
https://doi.org/10.1158/0008-5472.22421168.v1
https://doi.org/10.1158/0008-5472.22421168.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Regulatory T cells (Treg) are immunosuppressive and negatively impact response to cancer immunotherapies. CREB-binding protein (CBP) and p300 are closely related acetyltransferases and transcriptional coactivators. Here, we evaluate the mechanisms by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00dfda38464bfe249a1e9c6500c6cdae
https://doi.org/10.1158/0008-5472.c.6510854.v1
https://doi.org/10.1158/0008-5472.c.6510854.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Supplementary figure 4 shows additional mass spectrometry analyses of CBP/p300 histone substrates along with prostacyclin measurement across cell types (naïve T cell and Treg) following treatment with CBP/p300 inhibitor GNE-781.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533b5aeebf4851850560a100c1167b3b
https://doi.org/10.1158/0008-5472.22421165.v1
https://doi.org/10.1158/0008-5472.22421165.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Supplementary figure 5 shows additional analyses of the CBP/p300 LOF mutations identified in the patient tissue samples along with predictions of functional effects of these mutations; additional immunofluorescence scores of immune cells and their ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7004f6159eb5618d876ab4b7204baa47
https://doi.org/10.1158/0008-5472.22421159.v1
https://doi.org/10.1158/0008-5472.22421159.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Supplementary figure 1 shows supportive RT-qPCR data on the transcriptional modulation of Treg differentiation by CBP/p300 along with the proliferation effects of CBP/p300 inhibitor GNE-781 on T cells and Tregs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079c31a288a35d9a6cd8d9e72e32e33d
https://doi.org/10.1158/0008-5472.22421177.v1
https://doi.org/10.1158/0008-5472.22421177.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Supplementary figure 2 shows supportive naïve T cell transcriptional profiling data and additional supportive TF analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e8820d20735b3e4c843b451a8b7669
https://doi.org/10.1158/0008-5472.22421171
https://doi.org/10.1158/0008-5472.22421171
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Supplementary figure 6 shows additional assessments of B cells in FL patient tissue samples and their activation status and supportive in vitro B cells findings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9942124e2a8a986223264629d0408b
https://doi.org/10.1158/0008-5472.22421156
https://doi.org/10.1158/0008-5472.22421156
Autor:
Christopher W. Davies, Angela J. Oh, Rana Mroue, Micah Steffek, John M. Bruning, Yang Xiao, Siyu Feng, Sangeeta Jayakar, Emily Chan, Vidhyalakshmi Arumugam, Sean Carlo Uribe, Jake Drummond, Alexandra Frommlet, Cheng Lu, Yvonne Franke, Mark Merchant, Hartmut Koeppen, John G. Quinn, Sushant Malhotra, Steve Do, Lewis Gazzard, Hans E. Purkey, Joachim Rudolph, Melinda M. Mulvihill, James T. Koerber, Weiru Wang, Marie Evangelista
Publikováno v:
Nature Biotechnology. 40:769-778
Small molecules that stabilize inactive protein conformations are an underutilized strategy for drugging dynamic or otherwise intractable proteins. To facilitate the discovery and characterization of such inhibitors, we created a screening platform t
Autor:
Namrata Patil, Barzin Nabet, Sören Müller, Hartmut Koeppen, Wei Zou, Jennifer Giltnane, Jason Cheng, Chikara Takahashi, Avantika Chitre, Linda Rangell, Sangeeta Jayakar, William O’Gorman, Marcus Ballinger, Romain Banchereau, David Shames
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Sandra Rost, Zora Modrusan, Ciara Martin, Yeqing Angela Yang, Sangeeta Jayakar, Veronica Ibarra-Lopez
Publikováno v:
Journal of Visualized Experiments.
Multiplexing enables the assessment of several markers on the same tissue while providing spatial context. Spatial Omics technologies allow both protein and RNA multiplexing by leveraging photo-cleavable oligo-tagged antibodies and probes, respective