Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Sangeeta Chawla"'
Autor:
Sangeeta Chawla, John O’Neill, Marina I. Knight, Yuqing He, Lei Wang, Erik Maronde, Sergio Gil Rodríguez, Gerben van Ooijen, Eduardo Garbarino-Pico, Eva Wolf, Ouria Dkhissi-Benyahya, Anjoom Nikhat, Shaon Chakrabarti, Shawn D. Youngstedt, Natalie Zi-Ching Mak, Ignacio Provencio, Henrik Oster, Namni Goel, Mario Caba, Maria Oosthuizen, Giles E. Duffield, Christopher Chabot, Seth J. Davis
Publikováno v:
Journal of Circadian Rhythms, Vol 22, Pp 2-2 (2024)
Chronobiology investigations have revealed much about cellular and physiological clockworks but we are far from having a complete mechanistic understanding of the physiological and ecological implications. Here we present some unresolved questions in
Externí odkaz:
https://doaj.org/article/db502127013240719d08119a18f1cd60
Autor:
Sangeeta Chawla, Henrik Oster, Giles E. Duffield, Erik Maronde, Mario E. Guido, Christopher Chabot, Ouria Dkhissi-Benyahya, Ignacio Provencio, Namni Goel, Shawn D. Youngstedt, Natalie Zi-Ching Mak, Mario Caba, Anjoom Nikhat, Shaon Chakrabarti, Lei Wang, Seth J. Davis
Publikováno v:
Journal of Circadian Rhythms, Vol 22, Pp 1-1 (2024)
Circadian Biology intersects with diverse scientific domains, intricately woven into the fabric of organismal physiology and behavior. The rhythmic orchestration of life by the circadian clock serves as a focal point for researchers across discipline
Externí odkaz:
https://doaj.org/article/a575223ac92d449cb7db174dcd3aca01
Autor:
Andrew D. James, Katherine P. Unthank, Isobel Jones, Nattanan Sajjaboontawee, Rebecca E. Sizer, Sangeeta Chawla, Gareth J. O. Evans, William J. Brackenbury
Publikováno v:
Physiological Reports, Vol 11, Iss 7, Pp n/a-n/a (2023)
Abstract Intracellular Ca2+ signaling and Na+ homeostasis are inextricably linked via ion channels and co‐transporters, with alterations in the concentration of one ion having profound effects on the other. Evidence indicates that intracellular Na+
Externí odkaz:
https://doaj.org/article/bb26b4acd581462d9729855e5f1d9389
Autor:
Anna Simon, Ming Yang, Joanne L. Marrison, Andrew D. James, Mark J. Hunt, Peter J. O’Toole, Paul M. Kaye, Miles A. Whittington, Sangeeta Chawla, William J. Brackenbury
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures and cognitive impairment, so better understandin
Externí odkaz:
https://doaj.org/article/83744fe99058415e8571e6153d33ff04
Autor:
Chris Ugbode, Nathan Garnham, Laura Fort-Aznar, Gareth J.O. Evans, Sangeeta Chawla, Sean T. Sweeney
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101712- (2020)
Reactive oxygen species (ROS) are generated during physiological bouts of synaptic activity and as a consequence of pathological conditions in the central nervous system. How neurons respond to and distinguish between ROS in these different contexts
Externí odkaz:
https://doaj.org/article/35a333530d47408292a33a443418f765
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Eslicarbazepine acetate (ESL) is a dibenzazepine anticonvulsant approved as adjunctive treatment for partial-onset epileptic seizures. Following first pass hydrolysis of ESL, S-licarbazepine (S-Lic) represents around 95% of circulating active metabol
Externí odkaz:
https://doaj.org/article/11c47f37010046e6ab38e9f0ef2c9ae4
The Parkinson ‘s Disease associated kinase LRRK2 is proposed to act through phosphorylation of Rab proteins, most notably Rab10. All Rabs participate in a GTPase cycle, in which GEFs (Guanine nucleotide exchange factors) promote membrane binding, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae040c5fe02f7dfbeca24ef88b3c2677
https://doi.org/10.1101/2023.05.23.541929
https://doi.org/10.1101/2023.05.23.541929
Autor:
David Jaciuch, C. Adam Middleton, Christopher J. H. Elliott, Jack Munns, Laurence G. Wilson, Alison Fellgett, Chris Ugbode, Sangeeta Chawla
Publikováno v:
Journal of Parkinson's Disease
Background: Inherited mutations in the LRRK2 protein are common causes of Parkinson’s disease, but the mechanisms by which increased kinase activity of mutant LRRK2 leads to pathological events remain to be determined. In vitro assays (heterologous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec79169cdb25a3a75d4e99d8ab9a6077
https://doi.org/10.3233/jpd-202421
https://doi.org/10.3233/jpd-202421
Autor:
Andrew D. James, Katherine P. Unthank, Isobel Jones, Nattanan Sajjaboontawee, Rebecca E. Sizer, Sangeeta Chawla, Gareth J.O. Evans, William J. Brackenbury
Intracellular Ca2+signalling and Na+homeostasis are inextricably linked via ion channels and co-transporters, with alterations in the concentration of one ion having profound effects on the other. Evidence indicates that intracellular Na+concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8548a2f06a217263e4eb0955fdf4e296
https://doi.org/10.1101/2022.08.10.503447
https://doi.org/10.1101/2022.08.10.503447
Autor:
Joanne Marrison, William J. Brackenbury, Mark J. Hunt, Anna Simon, Andrew D. James, Ming Yang, Paul M. Kaye, Peter O'Toole, Miles A. Whittington, Sangeeta Chawla
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures and cognitive impairment, so better understanding of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6731e77aefebf048484ada9017b11b2d
http://link.springer.com/article/10.1186/s12974-020-01753-0
http://link.springer.com/article/10.1186/s12974-020-01753-0