Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sangeeta, Karle"'
Publikováno v:
Molecular Immunology. 44:2707-2718
Antibodies (Abs) to the superantigenic determinant of HIV gp120 (gp120(SAg)) are potential protective agents against HIV infection. We report that the light chain subunits of Abs cloned from lupus patients using phage library methods bind and hydroly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e11cc2ba50daa7493e0a5a383a9621
https://doi.org/10.1016/j.molimm.2006.12.005
https://doi.org/10.1016/j.molimm.2006.12.005
Autor:
Sangeeta Karle, Marc E. Weksler, Carl V. Hanson, Yasuhiro Nishiyama, Stephanie Planque, Hiroaki Taguchi, Sudhir Paul
Publikováno v:
Springer Seminars in Immunopathology. 26:485-503
Antibodies (Abs) and enzymes are structural and functional relatives. Abs with promiscuous peptidase activity are ubiquitous in healthy humans, evidently derived from germline variable domain immunoglobulin genes encoding the serine protease-like nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8152f3d70484d7c0ddc6fb19e126f899
https://doi.org/10.1007/s00281-004-0191-1
https://doi.org/10.1007/s00281-004-0191-1
Autor:
Sangeeta Karle, Beverly Carol Handy, Hiroaki Taguchi, Carl V. Hanson, Allen B. Edmundson, Stephanie Planque, Yasuhiro Nishiyama, Robert L. Hunter, Sudhir Paul, Maria Salas
Publikováno v:
Journal of Biological Chemistry. 279:39611-39619
We report the selective catalytic cleavage of the HIV coat protein gp120, a B cell superantigen, by IgM antibodies (Abs) from uninfected humans and mice that had not been previously exposed to gp120. The rate of IgM-catalyzed gp120 cleavage was great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2836975aa184b5b80d4f384c6241a163
https://doi.org/10.1074/jbc.m406719200
https://doi.org/10.1074/jbc.m406719200
Autor:
Sangeeta Karle, Brian J. Poindexter, Sudhir Paul, Xiao Tong Song, Yasuhiro Nishiyama, Roger J. Bick, Yogesh Bangale, Allen B. Edmundson, Stephanie Planque, Hiroaki Taguchi
Publikováno v:
Journal of Biological Chemistry. 279:14024-14032
We report the chemical activity of immunoglobulin μ and κ/λ subunits expressed on the surface of B cells and in secreted IgM antibodies (Abs) found in the preimmune repertoire. Most of the nucleophilic reactivity of B cells measured by formation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c157e72c9be87e589061c3142b2f6d0
https://doi.org/10.1074/jbc.m312152200
https://doi.org/10.1074/jbc.m312152200
Autor:
Yukie Mitsuda, Hiroaki Taguchi, Sudhir Paul, Yasuhiro Nishiyama, Stephanie Planque, Yogesh Bangale, Sangeeta Karle, Gita Bhatia
Publikováno v:
Journal of Biological Chemistry. 279:7877-7883
We report the selective inactivation of proteolytic antibodies (Abs) to an autoantigen, the neuropeptide vasoactive intestinal peptide (VIP), by a covalently reactive analog (CRA) of VIP containing an electrophilic phosphonate diester at the Lys20 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5205e04e019a7e42e98e50f2886f713
https://doi.org/10.1074/jbc.m310950200
https://doi.org/10.1074/jbc.m310950200
Autor:
Yasuhiro Nishiyama, Sangeeta Karle, Stephanie Planque, Yogesh Bangale, Sudhir Paul, Lan Li, Ravishankar Kalaga, Yong Xin Zhou, Hiroaki Taguchi
Publikováno v:
The FASEB Journal. 17:628-635
The immunoregulatory neuropeptide vasoactive intestinal peptide (VIP) was cleaved by purified IgG from Fas-defective C3H/gld mice, lupus patients, and autoimmune thyroiditis patients. No VIPase activity was detected in IgG from control mice and human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8940a9f95ffcaba5e7bc9ae3e10260c3
https://doi.org/10.1096/fj.02-0475com
https://doi.org/10.1096/fj.02-0475com
Autor:
Gary S. Burr, Sudhir Paul, Yasuhiro Nishiyama, Stephanie Planque, Hiroaki Taguchi, Sangeeta Karle, Yong Xin Zhou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3167-3170
An antigenic peptide analogue consisting of HIV gp120 residues 421–431 (an antigen recognition site probe) with diphenyl amino(4-amidinophenyl)methanephosphonate located at the C-terminus (a catalytic site probe) was synthesized and its trypsin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29245acb435b32425c9ad46eb4472f56
https://doi.org/10.1016/s0960-894x(02)00640-6
https://doi.org/10.1016/s0960-894x(02)00640-6
Autor:
Hiroaki Taguchi, Sudhir Paul, Yasuhiro Nishiyama, Stephanie Planque, Sangeeta Karle, Yong Xin Zhou
Publikováno v:
Journal of Immunological Methods. 269:257-268
Monoclonal antibodies are suitable for therapeutic applications by virtue of their excellent target binding characteristics (specificity, affinity) and long half-life in vivo. Catalytic antibodies (CAbs) potentially represent a new generation of ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6b75a57a2fd7bf1ec6d6dad4531df7
https://doi.org/10.1016/s0022-1759(02)00236-3
https://doi.org/10.1016/s0022-1759(02)00236-3
Autor:
Hiroaki Taguchi, Jin Quan Luo, Gary S. Burr, Sudhir Paul, Yasuhiro Nishiyama, Yong Xin Zhou, Sangeeta Karle
Publikováno v:
Archives of Biochemistry and Biophysics. 402:281-288
Phosphonate monoesters have been assumed to serve as noncovalent transition state analogs for enzymes capable of catalyzing transacylation reactions. Here, we present evidence for the covalent reaction of certain serine proteinases and peptidase anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0449d0a7e5eef78bc13c769cacc9dd
https://doi.org/10.1016/s0003-9861(02)00087-5
https://doi.org/10.1016/s0003-9861(02)00087-5
Autor:
Gennady V. Gololobov, Yasuhiro Nishiyama, Hiroaki Taguchi, Alfonso Tramontano, Sudhir Paul, Yong Xin Zhou, Saji George, Sangeeta Karle, Stephanie Planque
Publikováno v:
Journal of Biological Chemistry. 276:28314-28320
The reactivity of phosphonate ester probes with several available proteolytic antibody (Ab) fragments was characterized. Irreversible, active site-directed inhibition of the peptidase activity was evident. Stable phosphonate diester-Ab adducts were r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98e11802990e520a9bca159a56e3956
https://doi.org/10.1074/jbc.m102530200
https://doi.org/10.1074/jbc.m102530200