Zobrazeno 1 - 10
of 697
pro vyhledávání: '"Sangdun Choi"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 7, Pp 1488-1500 (2024)
Abstract Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory response, which is essential for the proper functioning of our immune system. When infections or threats to the body’s defense mechanisms are detec
Externí odkaz:
https://doaj.org/article/5dd1e19bfcbb41efbf86de5a3adfb741
Autor:
Hee Eun Kim, Hyeon Jin Ju, Shina Kim, Young Hun Kim, Soyeon Lee, Sangdun Choi, Hyun C. Yoon, Hak Soo Choi, Moon Suk Kim
Publikováno v:
Materials Today Bio, Vol 26, Iss , Pp 101070- (2024)
Endogenous stem cell-driven in situ bone tissue formation has recently garnered increasing attention. Therefore, our study sought to refine methods to enhance the migration and subsequent osteogenic differentiation of these cells. Our innovative appr
Externí odkaz:
https://doaj.org/article/a126dda28c4646cbb1f6ce8817dc4167
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7666 (2024)
Autoimmunity refers to an organism’s immune response against its own healthy cells, tissues, or components, potentially leading to irreversible damage to vital organs. Central and peripheral tolerance mechanisms play crucial roles in preventing aut
Externí odkaz:
https://doaj.org/article/f895466fc3cc4211a07bda867e530f8a
Autor:
Jaemi Kim, Ji-Yun Kim, Hye-Eun Byeon, Ji-Won Kim, Hyoun-Ah Kim, Chang-Hee Suh, Sangdun Choi, MacRae F. Linton, Ju-Yang Jung
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6808 (2024)
Arterial macrophage cholesterol accumulation and impaired cholesterol efflux lead to foam cell formation and the development of atherosclerosis. Modified lipoproteins interact with toll-like receptors (TLR), causing an increased inflammatory response
Externí odkaz:
https://doaj.org/article/3e02c248b3784d24a69e88cb94109471
Neuroinflammation, autoinflammation, splenomegaly and anemia caused by bi-allelic mutations in IRAK4
Autor:
Samantha Cooray, Fiona Price-Kuehne, Ying Hong, Ebun Omoyinmi, Alice Burleigh, Kimberly C. Gilmour, Bilal Ahmad, Sangdun Choi, Mohammad W. Bahar, Paul Torpiano, Andrey Gagunashvili, Barbara Jensen, Evangelos Bellos, Vanessa Sancho-Shimizu, Jethro A. Herberg, Kshitij Mankad, Atul Kumar, Marios Kaliakatsos, Austen J. J. Worth, Despina Eleftheriou, Elizabeth Whittaker, Paul A. Brogan
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
We describe a novel, severe autoinflammatory syndrome characterized by neuroinflammation, systemic autoinflammation, splenomegaly, and anemia (NASA) caused by bi-allelic mutations in IRAK4. IRAK-4 is a serine/threonine kinase with a pivotal role in i
Externí odkaz:
https://doaj.org/article/cc3c5eb230e24ef5b59552b35c80a37b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4825-4835 (2023)
Anomalous NLRP3 inflammasome responses have been linked to multiple health issues, including but not limited to atherosclerosis, diabetes, metabolic syndrome, cardiovascular disease, and neurodegenerative disease. Thus, targeting NLRP3 and modulating
Externí odkaz:
https://doaj.org/article/a6ac73ff98604b5abc07db3e89ebdf38
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Coronaviruses induce severe upper respiratory tract infections, which can spread to the lungs. The nucleocapsid protein (N protein) plays an important role in genome replication, transcription, and virion assembly in SARS-CoV-2, the virus causing COV
Externí odkaz:
https://doaj.org/article/0aa04444587d46f39378eff3ed01404f
Autor:
Yun Bae Ji, Hye Yun Lee, Soyeon Lee, Young Hun Kim, Kun Na, Jae Ho Kim, Sangdun Choi, Moon Suk Kim
Publikováno v:
Materials Today Bio, Vol 16, Iss , Pp 100339- (2022)
Adapalene (AD) is an FDA-approved drug that shows good therapeutic efficacy for the treatment of acne vulgaris. However, due to its negative charge, AD cannot efficiently penetrate across the also negatively-charged skin membrane. This study is the f
Externí odkaz:
https://doaj.org/article/1e7dc33375564e0890cab0598edf25d9
Publikováno v:
Materials Today Bio, Vol 16, Iss , Pp 100386- (2022)
Triple-negative breast cancer (TNBC) patients are considered intractable, as this disease has few effective treatments and a very poor prognosis even in its early stages. Here, intratumoral therapy with resveratrol (Res), which has anticancer and met
Externí odkaz:
https://doaj.org/article/783c147219254cf099a08391ccc850e1
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The innate immune system is the first line of host’s defense against invading pathogens. Multiple cellular sensors that detect viral components can induce innate antiviral immune responses. As a result, interferons and pro-inflammatory cytokines ar
Externí odkaz:
https://doaj.org/article/da451243cdaf42089a0d44e54c63c6c4