Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sangdon Han"'
Autor:
Jian Zhao, Shimiao Wang, Stacy Markison, Sun Hee Kim, Sangdon Han, Mi Chen, Ana Karin Kusnetzow, Elizabeth Rico-Bautista, Michael Johns, Rosa Luo, R. Scott Struthers, Ajay Madan, Yunfei Zhu, Stephen F. Betz
Publikováno v:
ACS Medicinal Chemistry Letters. 14:66-74
Autor:
Jian Zhao, Shimiao Wang, Sun Hee Kim, Sangdon Han, Elizabeth Rico-Bautista, Emmanuel Sturchler, Julie Nguyen, Hannah Tan, Christine Staley, Ana Karin Kusnetzow, Stephen F. Betz, Michael Johns, Lance Goulet, Rosa Luo, Melissa Fowler, Jon Athanacio, Stacy Markison, R. Scott Struthers, Yunfei Zhu
Publikováno v:
Bioorganicmedicinal chemistry letters. 71
SST5 receptor activation potently inhibits insulin secretion from pancreatic β-cells, and an orally available nonpeptide selective SST5 agonist may be used to effectively manage the blood glucose levels of congenital HI patients to avoid severe hypo
Autor:
Sun Hee Kim, Taylor Kredel, Rosa Luo, Christine Staley, Ana Karin Kusnetzow, Jon Athanacio, Yun Fei Zhu, Stephen F. Betz, Melissa Fowler, Elizabeth Rico, Ajay Madan, Stacy Markison, Greg J. Reinhart, Agnes Antwan, Oleg Tsivkovski, Hannah Tan, Sangdon Han, Scott Struthers, Michael Johns, Julie Nguyen
Publikováno v:
Journal of the Endocrine Society
Adrenocorticotropic hormone (ACTH) is an important modulator of steroidal hormone synthesis and secretion from the adrenal gland and its selective activity at the melanocortin type 2 receptor (MC2) dictates the synthesis and secretion of cortisol (co
Autor:
Sangdon Han, David J. Unett, Michelle Solomon, Ibragim Gaidarov, Joel Gatlin, Xiaohua Chen, Graeme Semple, Todd Anthony, David Mills
Publikováno v:
Pharmacological Research. 131:185-198
GPR84 is an orphan G-protein coupled receptor, expressed on monocytes, macrophages and neutrophils and is significantly upregulated by inflammatory stimuli. The physiological role of GPR84 remains largely unknown. Medium chain fatty acids (MCFA) acti
Autor:
Michelle Solomon, Lars Thoresen, Robert M. Jones, Andrew J. Grottick, David J. Unett, Abu J.M. Sadeque, Chuan Chen, Ibragim Gaidarov, Hussien A. Al-Shamma, Jayant Thatte, Graeme Semple, Jae-Kyu Jung, Amin Usmani, Jeremy Barden, Xiuwen Zhu, Woo Hyun Yoon, Sangdon Han, Christopher Ronald J
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1309-1313
The discovery of a novel, selective and fully efficacious CB2 agonist with satisfactory pharmacokinetic and pharmaceutical properties is described. Compound 6 was efficacious in a rat model of osteoarthritis pain following oral administration and, in
Autor:
Scott Struthers, Rosa Luo, Stacy Markison, Yun Fei Zhu, Ana Karin Kusnetzow, Stephen F. Betz, Michael Johns, Greg J. Reinhart, Oleg Tsivkovski, Sun Hee Kim, Melissa Fowler, Agnes Antwan, Jon Athanacio, Ajay Madan, Sangdon Han, Taylor Kredel
Publikováno v:
Journal of the Endocrine Society
CRN04894 is an orally administered nonpeptide that is a potent and selective antagonist for adrenocorticotropic hormone (ACTH) acting at the melanocortin 2 receptor (MC2R) and is currently under development for the treatment of diseases of ACTH exces
Autor:
Ana Karin Kusnetzow, Scott Struthers, Michael Johns, Julie Nguyen, Elizabeth Rico-Bautista, Taylor Kredel, Rosa Luo, Yun Fei Zhu, Stacy Markison, Melissa Fowler, Stephen F. Betz, Greg J. Reinhart, Sun Hee Kim, Christine Staley, Sangdon Han, Hannah Tan, Jon Athanacio, Ajay Madan
Publikováno v:
Journal of the Endocrine Society
Cushing’s disease is most commonly the result of a microadenoma derived from pituitary corticotrophic cells that secretes excess adrenocorticotropic hormone (ACTH). ACTH is an important modulator of steroidal hormone synthesis and secretion from th
Autor:
Julie Nguyen, Sun Hee Kim, Hannah Tan, Elizabeth Rico-Bautista, Shimiao Wang, Yun-Fei Zhu, Jian Zhao, Ana Karin Kusnetzow, R. Scott Struthers, Stephen F. Betz, Sangdon Han
Publikováno v:
Bioorg Med Chem Lett
Nonpeptide sst2 agonists can provide a new treatment option for patients with acromegaly, carcinoid tumors, and neuroendocrine tumors. Our medicinal chemistry efforts have led to the discovery of novel 3,4-dihydroquinazoline-4-carboxamides as sst2 ag
Autor:
Khawja A. Usmani, Dawei Yue, Zhi-Liang Chu, Abu J.M. Sadeque, Chris Carroll, Chuan Chen, Hsin-Hui Shu, Sanju Narayanan, Hussein Al-Sharmma, Dominic P. Behan, Robert M. Jones, Graeme Semple, James N. Leonard, David J. Unett, Daniel J. Buzard, Michael Morgan, Juerg Lehmann, Imelda Calderon, Shiu-Feng Tung, Woo Hyun Yoon, Xiuwen Zhu, Sangdon Han, Andrew M. Kawasaki, Amy Siu-Ting Wong, Sun Hee Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3034-3038
The design and optimization of a novel trans-1,4-dioxycyclohexane GPR119 agonist series is described. A lead compound 21 was found to be a potent and efficacious GPR119 agonist across species, and possessed overall favorable pharmaceutical properties
Autor:
Hussien A. Al-Shamma, Michael Morgan, Ibragim Gaidarov, Huong T. Dang, Joel Gatlin, Marc Decaire, David J. Unett, Karoline Choi, Jeff Edwards, Dawei Yue, Abu J.M. Sadeque, Kevin Whelan, Yifeng Xiong, Lixia Fu, Jayant Thatte, Graeme Semple, Sonja Strah-Pleynet, Sangdon Han, Michelle Solomon, Dominic P. Behan, Jae-Kyu Jung, Sanju Narayanan, Lars Thoresen, Robert M. Jones, Chuan Chen, Xiuwen Zhu, Khawja A. Usmani, Cameron Pride, Ruoping Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:322-326
The design and synthesis of novel 1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalen-4-carboxamide CB2 selective ligands for the potential treatment of pain is described. Compound (R,R)-25 has good balance between CB2 agonist potency and selecti