The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells.

Autor: Medina Sanchez L; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Graduate Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Siller M; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Zeng Y; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; School of Medicine, Tsinghua University, Beijing, China., Brigleb PH; Graduate Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Sangani KA; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA., Soto AS; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Engl C; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Laughlin CR; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rana M; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Van Der Kraak L; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Pandey SP; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bender MJ; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Fitzgerald B; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hedden L; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Fiske K; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Taylor GM; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wright AP; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, USA., Mehta ID; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Rahman SA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Galipeau HJ; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada., Mullett SJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA., Gelhaus SL; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Health Sciences Mass Spectrometry Core, University of Pittsburgh, Pittsburgh, PA, USA., Watkins SC; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bercik P; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada., Nice TJ; Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, USA., Jabri B; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA., Meisel M; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Das J; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Center for Systems Immunology, Departments of Immunology and Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Dermody TS; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Verdú EF; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada., Hinterleitner R; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Institute of Infection, Inflammation, and Immunity, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. Electronic address: reinhard@pitt.edu.

Publikováno v: Immunity [Immunity] 2023 Aug 08; Vol. 56 (8), pp. 1862-1875.e9. Date of Electronic Publication: 2023 Jul 20.

Murine Norovirus Infection Induces T H 1 Inflammatory Responses to Dietary Antigens.

Autor: Bouziat R; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA., Biering SB; Committee on Microbiology, University of Chicago, Chicago, IL, USA., Kouame E; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA., Sangani KA; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA., Kang S; Department of Pathology, University of Chicago, Chicago, IL, USA., Ernest JD; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA., Varma M; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Brown JJ; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Urbanek K; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Dermody TS; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Ng A; Division of Gastroenterology, Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard University, Cambridge, MA, USA., Hinterleitner R; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA., Hwang S; Committee on Immunology, University of Chicago, Chicago, IL, USA; Committee on Microbiology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA. Electronic address: shwang@bsd.uchicago.edu., Jabri B; Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA. Electronic address: bjabri@bsd.uchicago.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2018 Nov 14; Vol. 24 (5), pp. 677-688.e5. Date of Electronic Publication: 2018 Nov 01.