Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Sangam Rajak"'
Autor:
Archana Tewari, Sangam Rajak, Sana Raza, Pratima Gupta, Bandana Chakravarti, Jyotika Srivastava, Chandra P. Chaturvedi, Rohit A. Sinha
Publikováno v:
Cells, Vol 12, Iss 14, p 1845 (2023)
Non-alcoholic steatohepatitis (NASH) is a clinically serious stage of non-alcoholic fatty liver disease (NAFLD). Histologically characterized by hepatocyte ballooning, immune cell infiltration, and fibrosis, NASH, at a molecular level, involves lipid
Externí odkaz:
https://doaj.org/article/b975eb2f9c424f2fa79a8bba6bba6499
Publikováno v:
Liver Research, Vol 5, Iss 2, Pp 62-71 (2021)
The incidence of non-alcoholic fatty liver disease (NAFLD) is rising rapidly across the globe. NAFLD pathogenesis is largely driven by an imbalance in hepatic energy metabolism, and at present, there is no approved drug for its treatment. The liver p
Externí odkaz:
https://doaj.org/article/a1d0de7cb6e44cc79d8055e94305efc4
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 26, Iss 2, Pp 206-237 (2020)
Non-alcoholic fatty liver disease (NAFLD) is one the fastest emerging manifestations of the metabolic syndrome worldwide. Non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD, may culminate into cirrhosis and hepatocellular cancer (HCC
Externí odkaz:
https://doaj.org/article/89801d8776684a18a0fad1c415aeb405
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Liver is the primary organ for energy metabolism and detoxification in the human body. Not surprisingly, a derangement in liver function leads to several metabolic diseases. Autophagy is a cellular process, which primarily deals with providing molecu
Externí odkaz:
https://doaj.org/article/1ab2c2ca228942a396bb41fd12a46582
Autor:
Sangam Rajak, Sherwin Xie, Archana Tewari, Sana Raza, Yajun Wu, Boon-Huat Bay, Paul M. Yen, Rohit A. Sinha
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101286- (2021)
Objective: Crinophagy is a secretory granule-specific autophagic process that regulates hormone content and secretion in endocrine cells. However, despite being one of the earliest described autophagic processes, its mechanism of action and regulatio
Externí odkaz:
https://doaj.org/article/9d5b34b8cf7b486dbe260df9e11bf0cd
Autor:
Sangam Rajak, Liliana F. Iannucci, Jin Zhou, B. Anjum, Nelson George, Brijesh K. Singh, Sujoy Ghosh, Paul M. Yen, Rohit A. Sinha
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The hepatic mevalonate (MVA) pathway, responsible for cholesterol biosynthesis, is a therapeutically important metabolic pathway in clinical medicine. Using an unbiased transcriptomics approach, we uncover a novel role of Unc-51 like autophagy activa
Externí odkaz:
https://doaj.org/article/78ab8411a3ac4d1e97a6b88b8b186848
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 127, Iss , Pp 110207- (2020)
Anabolic therapies for osteoporosis including dietary polyphenols promote osteoblast function by influencing its energy metabolism. Among the dietary polyphenols, the beneficial skeletal effects of genistein (an isoflavone), kaempferol (a flavone), r
Externí odkaz:
https://doaj.org/article/dcb6aff07dfd4342988e40c1e45e1136
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2391 (2020)
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They regulate key aspects of energy metabolism within cells. Recently, PPARα has been implicated
Externí odkaz:
https://doaj.org/article/d733bccc43644092b922d7e34b3df78a
Publikováno v:
Digestive Diseases and Sciences. 67:3497-3507
The liver is an organ of vital importance in the body; it is the center of metabolic activities and acts as the primary line of defense against toxic compounds. Exposure to environmental toxicants is an unavoidable fallout from rapid industrializatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838080c8aed924cdf1602986cbdd7103
https://doi.org/10.1007/s10620-021-07203-y
https://doi.org/10.1007/s10620-021-07203-y
Autor:
Rohit A. Sinha, Sangam Rajak, Paul M. Yen, Archana Tewari, Sana Raza, Shivmurat Yadav, Sujoy Ghosh
Publikováno v:
Biochemical and Biophysical Research Communications. 532:570-575
Hepatocellular cancer (HCC) is one of the leading causes of mortality worldwide. Unfortunately, a limited choice of anti-cancer drugs is available for treatment, owing to their minimal efficacy and development of acquired resistance. Autophagy, a cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94a97d24ca19fa91039606a59c2fd9e
https://doi.org/10.1016/j.bbrc.2020.08.068
https://doi.org/10.1016/j.bbrc.2020.08.068