Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Sang-phyo Hong"'
Autor:
Mathivanan Packiarajan, Xiaosui Pu, Robbin Brodbeck, Albert J. Robichaud, Andrew D. White, Christine G. Mazza Ferreira, Sang Phyo Hong, Gamini Chandrasena
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6469-6474
A novel series of aryl azetidinyl oxadiazoles are identified as mGluR5 positive allosteric modulators (PAMs) with improved physico-chemical properties. N-substituted cyclohexyl and exo-norbornyl carboxamides, and carbamate analogs of azetidines are m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cca7420ac50a30341308e3f70ec82c9
https://doi.org/10.1016/j.bmcl.2012.08.044
https://doi.org/10.1016/j.bmcl.2012.08.044
Autor:
Mathivanan Packiarajan, Christine G. Mazza Ferreira, Albert J. Robichaud, Xiaosui Pu, Sang Phyo Hong, Andrew D. White, Gamini Chandrasena, Robbin Brodbeck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5658-5662
A novel series of N-aryl pyrrolidinonyl oxadiazoles were identified as mGluR5 positive allosteric modulators (PAMs). Optimization of the initial lead compound 6a led to the identification of the 12c (-) enantiomer as a potent compound with acceptable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ff5ccebe25d413f517c93d0c9a9875
https://doi.org/10.1016/j.bmcl.2012.06.094
https://doi.org/10.1016/j.bmcl.2012.06.094
Autor:
Manuel Cajina, Megan Nattini, Michael Sabio, Michael S. Reitman, Dario Doller, Kevin G. Liu, Maria D. Bacolod, Hermogenes N. Jimenez, Sang-Phyo Hong, Michelle A. Uberti
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3235-3239
4-(1-Phenyl-1H-pyrazol-4-yl)quinoline (1) was identified by screening the Lundbeck compound collection, and characterized as having mGlu4 receptor positive allosteric modulator properties. Compound 1 is selective over other mGlu receptors and a panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b69b52a2908d3eaca5c8afd4f35dc6a
https://doi.org/10.1016/j.bmcl.2012.03.032
https://doi.org/10.1016/j.bmcl.2012.03.032
Autor:
Weitao Pan, Dan Sherman, Raphael Rios, Sang-phyo Hong, Farah Dhun, Matthew A. J. Duncton, Marc Labelle, Hai-Ying He, Mélissa Arbour, Yong-Jiang Xu, Hu Liu, Joel Kawakami
Publikováno v:
Tetrahedron Letters. 48:8943-8946
Differential reactivity of the amine functionality in a number of common 1,2-diamine starting materials is exploited to undertake an expedient synthesis of unsymmetrical 2,3,6-trisubstituted quinoxaline and unsymmetrical 2,3,7-trisubstituted pyridopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9005c303036bb3c81fdb5ed334ad98
https://doi.org/10.1016/j.tetlet.2007.10.117
https://doi.org/10.1016/j.tetlet.2007.10.117
Publikováno v:
Tetrahedron. 58:2905-2928
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a978022ce7c070daacdad15e9a4ce8eb
https://doi.org/10.1016/s0040-4020(02)00164-3
https://doi.org/10.1016/s0040-4020(02)00164-3
Autor:
Sang-phyo Hong, Matthias C. McIntosh
Publikováno v:
Tetrahedron. 57:5055-5060
The relative stereochemistry of 2,3-dialkylpentenoic acids and derivatives thereof can be easily determined by comparison of 13C NMR spectra of the syn and anti isomers. The chemical shifts of several of the resonances of the anti isomer lie downfiel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d9dcfcd8eae57180787a6588ec7966
https://doi.org/10.1016/s0040-4020(01)00349-0
https://doi.org/10.1016/s0040-4020(01)00349-0
Publikováno v:
Tetrahedron Letters. 41:155-159
Stereo- and regioselective oxidation of alkylidene cyclohexenes affords novel γ-lactones, δ-lactones and related structures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e0bc8af3768bb302264110b1b5365ab
https://doi.org/10.1016/s0040-4039(99)02043-2
https://doi.org/10.1016/s0040-4039(99)02043-2
Autor:
Quansheng Zhu, Huailing Zhong, Andrew T. E. Hartwick, Satchidananda Panda, Megumi Hatori, Roman Artymyshyn, Mohammad R. Marzabadi, Kenneth A. Jones, Patricia J. Sollars, Gary E. Pickard, Sang Phyo Hong, Ludovic S. Mure, Jayne R. Bramley, Jeffrey Sprouse
Publikováno v:
Nature chemical biology
Melanopsin, expressed in a subset of retinal ganglion cells, mediates behavioral adaptation to ambient light and other non-image-forming photic responses. This has raised the possibility that pharmacological manipulation of melanopsin can modulate se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540ccf64efd4e169f5d94c86c5e2a346
https://pubmed.ncbi.nlm.nih.gov/23974117
https://pubmed.ncbi.nlm.nih.gov/23974117
Autor:
Kevin G. Liu, Dario Doller, Albert J. Robichaud, Maria D. Bacolod, Sang-Phyo Hong, Michael Sabio, John R. Peterson, Zack Zou, Michelle A. Uberti, Gil Ma
Publikováno v:
Journal of medicinal chemistry. 54(14)
There is an increasing amount of evidence to support that activation of the metabotropic glutamate receptor 4 (mGlu4 receptor), either with an orthosteric agonist or a positive allosteric modulator (PAM), provides impactful interventions in diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8342159f7d99c53e16359d8cfd4afe
https://pubmed.ncbi.nlm.nih.gov/21688779
https://pubmed.ncbi.nlm.nih.gov/21688779
Autor:
Boshan Li, Sang Phyo Hong, Kai Lu, Gamini Chandrasena, Bin Chen, Eldemenky Eman Mohammed, Gil Ma, Andrew D. White, Jiang Yu, Mathivanan Packiarajan, Kenneth A. Jones
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
A series of potent indolyl azetidine rMCHR1 antagonists were found to show poor CNS penetration due to Pgp efflux. We envisioned a strategy which included: lowering basicity; changing the conformational flexibility motif; and removal of a hydrogen bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bf2e14afed5c4d7c49d392d48ee5e2
https://pubmed.ncbi.nlm.nih.gov/21802292
https://pubmed.ncbi.nlm.nih.gov/21802292