Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Sang-je Park"'
Publikováno v:
Stem Cell Research, Vol 65, Iss , Pp 102977- (2022)
Cynomolgus monkeys, due to their close anatomical, genetic and physiological similarity to humans, have been employed as a popular laboratory non-human primate model over rodents. Primate animal induced pluripotent stem cell (iPSC) have been used to
Externí odkaz:
https://doaj.org/article/6d0a72699dd24ae0bfc185b0bf0931d9
Publikováno v:
Stem Cell Research, Vol 64, Iss , Pp 102887- (2022)
Cynomolgus monkeys, a non-human primate species, are genetically and physiologically similar to humans; hence, they have been employed as an ideal developmental and biomedical model. Non-human primate animals and their induced pluripotent stem cell (
Externí odkaz:
https://doaj.org/article/a31a22eaade84a509d16c171882434e4
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Transposable elements (TEs) are DNA sequences that cut or introduced into the genome, and they represent a massive portion of the human genome. TEs generate a considerable number of microRNAs (miRNAs) are derived from TEs (MDTEs). Numerous m
Externí odkaz:
https://doaj.org/article/339483f0324c4a6d85cb5d7d36b387c5
Autor:
Hyeon-Mu Cho, Se-Hee Choe, Young-Hyun Kim, Hye-Ri Park, Hee-Eun Lee, Ja-Rang Lee, Sang-Je Park, Jae-Won Huh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Transposable elements cause alternative splicing (AS) in different ways, contributing to transcript diversification. Alternative polyadenylation (APA), one of the AS events, is related to the generation of mRNA isoforms in 70% of human genes
Externí odkaz:
https://doaj.org/article/0b8e9df5dd3e4c8da179b4056626899f
Autor:
Se-Hee Choe, Sang-Je Park, Hyeon-Mu Cho, Hye-Ri Park, Ja-Rang Lee, Young-Hyun Kim, Jae-Won Huh
Publikováno v:
BMC Evolutionary Biology, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Alternative splicing (AS) generates various transcripts from a single gene and thus plays a significant role in transcriptomic diversity and proteomic complexity. Alu elements are primate-specific transposable elements (TEs) and c
Externí odkaz:
https://doaj.org/article/44089befd26c47d8b525acc51a3a083d
Autor:
Hyeon-Mu Cho, Sang-Je Park, Se-Hee Choe, Ja-Rang Lee, Sun-Uk Kim, Yeung-Bae Jin, Ji-Su Kim, Sang-Rae Lee, Young-Hyun Kim, Jae-Won Huh
Publikováno v:
BMC Evolutionary Biology, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background The BLOC1S2 gene encodes the multifunctional protein BLOS2, a shared subunit of two lysosomal trafficking complexes: i) biogenesis of lysosome-related organelles complex-1 and i) BLOC-1-related complex. In our previous study, we i
Externí odkaz:
https://doaj.org/article/768748c26a74478081caa40955346900
Autor:
Bon-Sang Koo, Dong-Ho Lee, Philyong Kang, Kang-Jin Jeong, Sangil Lee, Kijin Kim, Youngjeon Lee, Jae-Won Huh, Young-Hyun Kim, Sang-Je Park, Yeung Bae Jin, Sun-Uk Kim, Ji-Su Kim, Yeonghoon Son, Sang-Rae Lee
Publikováno v:
Laboratory Animal Research, Vol 35, Iss 1, Pp 1-6 (2019)
Abstract Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematologic and biochemical reference i
Externí odkaz:
https://doaj.org/article/1550d03262f049a18a910567ef26cabe
Autor:
Ja-Rang Lee, Dong-Sung Ryu, Sang-Je Park, Se-Hee Choe, Hyeon-Mu Cho, Sang-Rae Lee, Sun-Uk Kim, Young-Hyun Kim, Jae-Won Huh
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background The characterization of genomic or epigenomic variation in human and animal models could provide important insight into pathophysiological mechanisms of various diseases, and lead to new developments in disease diagnosis and clini
Externí odkaz:
https://doaj.org/article/ff7c7b47e6dc4f7e97c0865ab66c7e1f
Autor:
Seung-Bin Yoon, Young-Ho Park, Seon-A Choi, Hae-Jun Yang, Pil-Soo Jeong, Jae-Jin Cha, Sanghoon Lee, Seung Hwan Lee, Jong-Hee Lee, Bo-Woong Sim, Bon-Sang Koo, Sang-Je Park, Youngjeon Lee, Young-Hyun Kim, Jung Joo Hong, Ji-Su Kim, Yeung Bae Jin, Jae-Won Huh, Sang-Rae Lee, Bong-Seok Song, Sun-Uk Kim
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219978 (2019)
X-box binding protein 1 (XBP1) mRNA processing plays a crucial role in the unfolded protein response (UPR), which is activated in response to endoplasmic reticulum (ER) stress. Upon accumulation of the UPR-converted XBP1 mRNA splicing from an unsplic
Externí odkaz:
https://doaj.org/article/fc817dc0e4634c3a92b31487fa103813
Autor:
Eun A. Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee
Publikováno v:
Plants, Vol 10, Iss 5, p 837 (2021)
Background: Obesity due to an excessive intake of nutrient disturbs the hypothalamus-mediated energy metabolism subsequently develops metabolic disorders. In this study, we investigated the effect of pine needle extract (PNE) on the hypothalamic proo
Externí odkaz:
https://doaj.org/article/b1ee4b333a9746a8bd20d9ac93312f5a