Výsledky vyhledávání - "Sang-Oh Yoon"

Akademický článek

mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

Autor: Sejeong Shin, Min-Joon Han, Mark P. Jedrychowski, Ziyang Zhang, Kevan M. Shokat, David R. Plas, Noah Dephoure, Sang-Oh Yoon

Publikováno v: Cell Reports, Vol 42, Iss 8, Pp 112868- (2023)

Summary: Cells maintain and dynamically change their proteomes according to the environment and their needs. Mechanistic target of rapamycin (mTOR) is a key regulator of proteostasis, homeostasis of the proteome. Thus, dysregulation of mTOR leads to

Externí odkaz: https://doaj.org/article/e32b0783630a4739a55f2de3b20572f4

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Akademický článek

The primitive growth factor NME7AB induces mitochondrially active naïve-like pluripotent stem cells

Autor: Carla O'Reilly, Qian Qi, Jennifer L. Peters, Yong Cheng, Sang-Oh Yoon, Min-Joon Han

Publikováno v: Biochemistry and Biophysics Reports, Vol 20, Iss , Pp - (2019)

Naïve pluripotent stem cells (PSCs) display a distinctive phenotype when compared to their “primed” counterparts, including, but not limited to, increased potency to differentiate and more robust mitochondrial respiration. The cultivation and ma

Externí odkaz: https://doaj.org/article/c2261593af5b4587aded71d01e4487b6

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Akademický článek

Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia

Autor: Hongqi Liu, Xizhi Feng, Kelli N. Ennis, Catherine A. Behrmann, Pranjal Sarma, Tony T. Jiang, Satoshi Kofuji, Liang Niu, Yiwen Stratton, Hala Elnakat Thomas, Sang-Oh Yoon, Atsuo T. Sasaki, David R. Plas

Publikováno v: Cell Reports, Vol 18, Iss 9, Pp 2088-2095 (2017)

Summary: Genetic S6K1 inactivation can induce apoptosis in PTEN-deficient cells. We analyzed the therapeutic potential of S6K1 inhibitors in PTEN-deficient T cell leukemia and glioblastoma. Results revealed that the S6K1 inhibitor LY-2779964 was rela

Externí odkaz: https://doaj.org/article/2f09586356c44ad081807d72b47620bc

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Akademický článek

Transcriptional repression of Bim by a novel YY1-RelA complex is essential for the survival and growth of Multiple Myeloma.

Autor: Veena Potluri, Sunil K Noothi, Subrahmanya D Vallabhapurapu, Sang-Oh Yoon, James J Driscoll, Charles H Lawrie, Sivakumar Vallabhapurapu

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e66121 (2013)

Multiple Myeloma (MM) is an incurable plasma cell cancer that is caused by several chromosomal translocations and gene deletions. Although deregulation of several signaling pathways including the Nuclear Factor-Kappa B (NF-κB) pathway has been repor

Externí odkaz: https://doaj.org/article/31b445cb5edd4165a2976f868f4162c4

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Akademický článek

Integrin Trafficking and Tumor Progression

Autor: Sejeong Shin, Laura Wolgamott, Sang-Oh Yoon

Publikováno v: International Journal of Cell Biology, Vol 2012 (2012)

Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highl

Externí odkaz: https://doaj.org/article/1976e7c4f702471999fd819fdae87749

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