Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Sang-Hie Kim"'
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 41:869-873
Background: Significant antitumor activity has been reported with the combined use of 13- cis -retinoic acid (cRA) and interferon-α2a (IFN-α) in the treatment of advanced-stage cervical cancers and skin cancers. Since IFN-α has been shown to be a
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 34:375-380
Purpose : Because agents that interfere with thiol metabolism and glutathione S-transferase (GST) functions have been shown to enhance antitumor effects of alkylating agents in vitro and in vivo, the present study was conceived on the basis that an i
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 33:861-868
Purpose: To demonstrate in a wel-characterized tumor model that the radiosensitivity of tumor cells transduced with a herpes simplex virus thymidine kinase gene (HS-tk) would be selectively enhanced by antiviral agents. Methods and Materials: Rat 9L
Publikováno v:
Radiotherapy and Oncology. 36:225-228
Pharmacokinetic analyses were performed on blood samples of 12 patients undergoing treatment with nicotinamide, hyperthermia and radiation therapy for a variety of recurrent/metastatic cancers. Escalating oral doses of 3, 4, 5, 6 and 10 g of nicotina
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 30:99-104
Purpose: Estramustine (EM), an antimicrotubule agent, binds microtubule-associated proteins, causes spindle dis-assembly, and arrests cells at the late G 2 /M phase of the cell cycle. Since cells in the G 2 /M phase are the most radiosensitive and so
Publikováno v:
Journal of Neuro-Oncology. 9:9-15
Interstitial brachytherapy with low energy radionuclides is becoming widely used in conjunction with external beam radiotherapy in the treatment of primary malignant gliomas of the brain. Few radiobiological studies have been carried out with low dos
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 18:583-586
in vivo murine tumor experiments were carried out to determine whether 6-thioguanine (6-TG) could enhance the cytotoxic effects of radiation on tumors. The combined effects of single and fractionated x-irradiation were evaluated on the transplanted m
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 84:S481-S482
Publikováno v:
International journal of radiation oncology, biology, physics. 42(4)
Purpose: To determine whether the administration of ThymitaqTM (AG337), a selective inhibitor of thymidylate synthase (TS), enhances radiation-induced cytotoxicity in vitro and increases tumor control rate in vivo. Methods and Materials: In vitro stu
Publikováno v:
Human gene therapy. 8(1)
To ascertain whether concomitant expression of Escherichia coli deaminase (CD) and herpes simplex virus type-1 thymidine kinase (HSV-1 TK) could mediate greater levels of cytotoxicity beyond that observed with either suicide gene alone, 9L gliosarcom