Zobrazeno 1 - 10
of 507
pro vyhledávání: '"Sang-Geon Kim"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Inflammatory bowel disease is defined by inflammation and immune dysregulation. This study investigated the effects of Gα13 liver-specific knockout (LKO) on proximal and distal colons of dextran sodium sulfate (DSS)-induced mice in conjunct
Externí odkaz:
https://doaj.org/article/b66bf5bb51fc4e62aa5698a86ea0960e
Autor:
Minh Tuan Nguyen, Gi Jeong Lee, Boram Kim, Hyun Ji Kim, Jihoon Tak, Mi Kyung Park, Eun Ji Kim, Gyeoung Jin Kang, Seung Bae Rho, Ho Lee, Kyung Lee, Sang Geon Kim, Chang Hoon Lee
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107512- (2024)
Hepatocellular carcinoma (HCC) comprises the majority of primary liver cancers and possesses a low 5-year survival rate when in the advanced stages. Anillin (ANLN), a key player in cell growth and cytokinesis, is implicated in HCC development. Curren
Externí odkaz:
https://doaj.org/article/2595b1de8ce64df9a8982706259fa398
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Inflammatory bowel disease (IBD) pathogenesis involves complex inflammatory events and cell death. Although IBD involves mainly necrosis in the digestive tract, pyroptosis has also been recognized. Nonetheless, the underlying basis is elusiv
Externí odkaz:
https://doaj.org/article/bd1dd9a2c5994fac8683006fdfafb72a
Autor:
Yun Seok Kim, Bongsub Ko, Da Jung Kim, Jihoon Tak, Chang Yeob Han, Joo-Youn Cho, Won Kim, Sang Geon Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Alcohol consumption promotes neutral fat accumulation in the liver. Here, the authors report that alcohol induces aryl hydrocarbon receptor AhR in the liver, and hepatocyte-specific AhR deletion protects against alcohol induced accumulation potential
Externí odkaz:
https://doaj.org/article/ccd01459010a456f84769c2dca0141e8
Autor:
Ayoung Kim, Ja Hyun Koo, Xing Jin, Wondong Kim, Shi‐Young Park, Sunghyouk Park, Eugene P. Rhee, Cheol Soo Choi, Sang Geon Kim
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 12, Iss 6, Pp 1669-1689 (2021)
Abstract Background Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and muscle mass control. Perturbation of the skeletal muscle metabolism elevates the risk of a variety of diseas
Externí odkaz:
https://doaj.org/article/4c61d08a4f9d436eb807cf8f8cb08fa6
Autor:
Yun Seok Kim, Sang Geon Kim
Publikováno v:
Clinical and Molecular Hepatology, Vol 26, Iss 4, Pp 715-727 (2020)
Alcoholic and non-alcoholic liver diseases begin from an imbalance in lipid metabolism in hepatocytes as the earliest response. Both liver diseases share common disease features and stages (i.e., steatosis, hepatitis, cirrhosis, and hepatocellular ca
Externí odkaz:
https://doaj.org/article/99d02ef3d281427e87f0d3af4b45a003
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 6, Pp 896-910 (2020)
Metabolic diseases: Going after G proteins Understanding the activities of two members of a vital category of proteins called G proteins, which initiate metabolic changes when signaling molecules bind to cells, could lead to new therapies for many di
Externí odkaz:
https://doaj.org/article/5ecf2d0578434e9e89906326e6ad3873
Publikováno v:
Hepatology Communications, Vol 3, Iss 10, Pp 1373-1387 (2019)
Liver X receptor‐alpha (LXRα) acts as a double‐edged sword in different biological situations. Given the elusive role of LXRα in hepatocyte viability, this study investigated whether LXRα protects hepatocytes from injurious stimuli and the und
Externí odkaz:
https://doaj.org/article/0806e569f9124caabe724886a66b2b64
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 488-503 (2019)
Background: The injured liver loses normal function, with concomitant decrease of key identity genes. Super-enhancers contribute to mammalian cell identity. Here, we identified core transcription factors (TFs) that are active in hepatocytes, using ge
Externí odkaz:
https://doaj.org/article/6a1d2957b06e4b408956e8a27deaf23b
Autor:
Tsukasa Shimauchi, Takuro Numaga-Tomita, Yuri Kato, Hiroyuki Morimoto, Kosuke Sakata, Ryosuke Matsukane, Akiyuki Nishimura, Kazuhiro Nishiyama, Atsushi Shibuta, Yutoku Horiuchi, Hitoshi Kurose, Sang Geon Kim, Yasuteru Urano, Takashi Ohshima, Motohiro Nishida
Publikováno v:
Cells, Vol 11, Iss 13, p 2041 (2022)
Retarded revascularization after progressive occlusion of large conductance arteries is a major cause of bad prognosis for peripheral artery disease (PAD). However, pharmacological treatment for PAD is still limited. We previously reported that suppr
Externí odkaz:
https://doaj.org/article/e89d2112d64a412badfa2e0abc81ba01