Zobrazeno 1 - 10
of 638
pro vyhledávání: '"Sang Kook Lee"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract As the complexity of organic molecules utilized by mankind increases, the phenomenon of atropisomerism is more frequently encountered. While a variety of well-established methods enable the control of a stereogenic center, a catalytic method
Externí odkaz:
https://doaj.org/article/98e906878822499d9a513083c75b050c
Autor:
Jee Hyung Lee, Haeryoung Kim, Sang Hyub Lee, Ja-Lok Ku, Jung Won Chun, Ha Young Seo, Soon Chan Kim, Woo Hyun Paik, Ji Kon Ryu, Sang Kook Lee, Andrew M. Lowy, Yong-Tae Kim
Publikováno v:
Gut and Liver, Vol 16, Iss 4, Pp 625-636 (2022)
Background/Aims: Three-dimensional cultures of human pancreatic cancer tissue also known as “organoids” have largely been developed from surgical specimens. Given that most patients present with locally advanced and/or metastatic disease, such or
Externí odkaz:
https://doaj.org/article/10db783526254b6fa2e792747897acb9
Autor:
Jiyoon Park, Hang Su Cho, Dong Hyun Moon, Donghoon Lee, Youngjoo Kal, Sangwon Cha, Sang Kook Lee, Yeo Joon Yoon, Dong-Chan Oh
Publikováno v:
Frontiers in Marine Science, Vol 10 (2023)
The xiamycins are bioactive indolosesquiterpenoids that have been isolated from actinobacterial strains belonging to the Streptomyces genus. The overexpression of orf2011, which encodes the LuxR family regulator in a marine Streptomyces strain (HK18)
Externí odkaz:
https://doaj.org/article/ea58c06565344440b8daaca3f44abbcb
Autor:
Won Kyung Kim, Joon-Shik Shin, Jinho Lee, Wonil Koh, In-Hyuk Ha, Hyen Joo Park, Sang Kook Lee, Jin Young Hong
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
The current standard for the pharmacological management of lumbar disk herniation (LDH), involving non-steroidal anti-inflammatory drugs, muscle relaxants, and opioid analgesics, often carries a risk of adverse events. The search for alternative ther
Externí odkaz:
https://doaj.org/article/5331360e7569408f9db7d5376a44ba6f
Autor:
Ahmed H. E. Hassan, Cai Yi Wang, Cheol Jung Lee, Hye Rim Jeon, Yeonwoo Choi, Suyeon Moon, Chae Hyeon Lee, Yeon Ju Kim, Soo Bin Cho, Kazem Mahmoud, Selwan M. El-Sayed, Sang Kook Lee, Yong Sup Lee
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1597 (2023)
A library of 24 congeners of the natural product sulfuretin were evaluated against nine panels representing nine cancer diseases. While sulfuretin elicited very weak activities at 10 µM concentration, congener 1t was identified as a potential compou
Externí odkaz:
https://doaj.org/article/89760945d3114dbe9bfc7c621835eea4
Autor:
Thanh-Hau Huynh, Eun Seo Bae, Bo Eun Heo, Jayho Lee, Joon Soo An, Yun Kwon, Sang-Jip Nam, Ki-Bong Oh, Jichan Jang, Sang Kook Lee, Dong-Chan Oh
Publikováno v:
Marine Drugs, Vol 21, Iss 9, p 500 (2023)
Two new proton-deficient metabolites, tandocyclinones A and B (1 and 2), were discovered via the chemical profiling of the Streptomyces sp. strain TDH03, which was isolated from a marine sediment sample collected from the intertidal mudflat in Tando
Externí odkaz:
https://doaj.org/article/d26beefa22e44ad6bbff47f897353ea8
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 157, Iss , Pp 114039- (2023)
Although gemcitabine-based chemotherapy is common and effective for pancreatic cancer (PC), acquired drug resistance is one of the major reasons for treatment failure. Therefore, a novel therapeutic approach for gemcitabine-resistant PC is required.
Externí odkaz:
https://doaj.org/article/6972fbe1db6c41f6a0f583cb0f908de2
Publikováno v:
Marine Drugs, Vol 21, Iss 7, p 405 (2023)
Four new chlorinated cycloaromatized enediyne compounds, jejucarbosides B–E (1–4), were discovered together with previously-identified jejucarboside A from a marine actinomycete strain. Compounds 1–4 were identified as new chlorinated cyclopent
Externí odkaz:
https://doaj.org/article/291ed4efdd2a4f639d4b8ce328918a70
Autor:
Mark Borris D. Aldonza, Roben D. Delos Reyes, Young Seo Kim, Jayoung Ku, Ana Melisa Barsallo, Ji-Young Hong, Sang Kook Lee, Han Suk Ryu, YongKeun Park, Je-Yoel Cho, Yoosik Kim
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-22 (2021)
Abstract Drug resistance remains the major culprit of therapy failure in disseminated cancers. Simultaneous resistance to multiple, chemically different drugs feeds this failure resulting in cancer relapse. Here, we investigate co-resistance signatur
Externí odkaz:
https://doaj.org/article/6a9ce31adb9b43ee90c928b9bc9e7e9b
Autor:
Kay Zin Kyaw, Jiyoon Park, Seung Ho Oh, Ji Yun Lee, Eun Seo Bae, Hyen Joo Park, Dong-Chan Oh, Sang Kook Lee
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 491 (2023)
Colorectal cancer (CRC) is one of the most prevalent tumors with high metastatic potential; consequently, finding new drug candidates that suppress tumor metastasis is essential. Apoptolidin A is a macrocyclic lactone produced by Amycolatopsis sp. DW
Externí odkaz:
https://doaj.org/article/6e17fc566d0843c1b58a5fae9e8a78f4