Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sang B. Woo"'
Publikováno v:
Journal of Neuroscience Research. 90:2259-2271
Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons. The high-affinity binding on the cell surface is believed to involve a heteroreceptor complex, but i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43afbb622ffa93bbd4ca56628e13ad1
https://doi.org/10.1002/jnr.23116
https://doi.org/10.1002/jnr.23116
Autor:
Jose Carlos Rivera, Sang B. Woo, Shi ZhiHua, Marinko V. Sarunic, Alba Galan, Hrishikesh M. Mehta, Jing Xu, H. Uri Saragovi, Kenneth E. Neet, Hinyu Nedev, Yujing Bai, Pauline Dergham
Publikováno v:
Journal of Biological Chemistry. 285:39392-39400
In normal adult retinas, NGF receptor TrkA is expressed in retinal ganglion cells (RGC), whereas glia express p75(NTR). During retinal injury, endogenous NGF, TrkA, and p75(NTR) are up-regulated. Paradoxically, neither endogenous NGF nor exogenous ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a510995e4ff0ca1db94785aae36b1b1
https://doi.org/10.1074/jbc.m110.147801
https://doi.org/10.1074/jbc.m110.147801
Publikováno v:
Journal of Biological Chemistry. 284:33600-33613
Afflicted neurons in Alzheimer disease have been shown to display an imbalance in the expression of TrkA and p75(NTR) at the cell surface, and administration of nerve growth factor (NGF) has been considered and attempted for treatment. However, wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c399c668c59792b7cdea423e091c70dc
https://doi.org/10.1074/jbc.m109.058420
https://doi.org/10.1074/jbc.m109.058420
Publikováno v:
Journal of Biological Chemistry. 282:16754-16763
Neurotrophins signal via Trk tyrosine kinase receptors. Nerve growth factor (NGF) is the cognate ligand for TrkA, the brain-derived neurotrophic factor for TrkB, and NT-3 for TrkC. NT-3 also binds TrkA as a lower affinity heterologous ligand. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c97106e1bffc02723f0a3a6bba46ded
https://doi.org/10.1074/jbc.m701996200
https://doi.org/10.1074/jbc.m701996200
Publikováno v:
Drug Development Research. 57:122-133
Mumie, a plant humus matter from rocks, is known as anabolic and a stimulator of bone regeneration in the Russian and Indian systems of health and medicine. The water-soluble fraction of mumie from Uzbekistan was characterized using 1H NMR and infrar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed07e8723ce950d752768eef0b0b798e
https://doi.org/10.1002/ddr.10120
https://doi.org/10.1002/ddr.10120
Autor:
Philip N. Vrkljan, Kenneth E. Neet, Mark Solc, Gail Lawrance, Igor L. Shamovsky, Richard J. Riopelle, Joan I. Post, Suzanne M. Dostaler, Gregory M. Ross, Sang B. Woo
Publikováno v:
Journal of Neurochemistry. 78:515-523
It has recently been shown that transition metal cations Zn2+ and Cu2+ bind to histidine residues of nerve growth factor (NGF) and other neurotrophins (a family of proteins important for neuronal survival) leading to their inactivation. Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::905db55da3d8786bea8b760b41c6c894
https://doi.org/10.1046/j.1471-4159.2001.00427.x
https://doi.org/10.1046/j.1471-4159.2001.00427.x
Autor:
Sang B. Woo, Kenneth E. Neet
Publikováno v:
Journal of Biological Chemistry. 271:24433-24441
The role of the four histidine residues in receptor binding and activity of mouse nerve growth factor (NGF) was investigated using both site-directed mutagenesis and chemical modification with diethyl pyrocarbonate. Replacement of His-75 or His-84 wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b486a2e402da4f48817ddc6ba389330b
https://doi.org/10.1074/jbc.271.40.24433
https://doi.org/10.1074/jbc.271.40.24433
Ligand-dependent TrkA activity in brain differentially affects spatial learning and long-term memory
Autor:
Edith Hamel, Xin-Kang Tong, Kenneth E. Neet, Fouad Brahimi, Yiu Chung Tse, H. Uri Saragovi, Tak Pan Wong, Tahar Aboulkassim, Sang B. Woo
Publikováno v:
Molecular pharmacology. 80(3)
In the central nervous system, the nerve growth factor (NGF) receptor TrkA is expressed primarily in cholinergic neurons that are implicated in spatial learning and memory, whereas the NGF receptor p75(NTR) is expressed in many neuronal populations a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d249e0610d19e24e3f431e50fad3ef7a
https://pubmed.ncbi.nlm.nih.gov/21616921
https://pubmed.ncbi.nlm.nih.gov/21616921
Autor:
Bhami C. Shenoy, Sang B. Woo, David Samols, Harland G. Wood, Ganesh K. Kumar, William J. Magner, Helga Beegen
Publikováno v:
Journal of Biological Chemistry. 268:16413-16419
Transcarboxylase from Propionibacterium shermanii is a biotin-containing enzyme which catalyzes the reversible transfer of a carboxyl group from methylmalonyl-CoA to pyruvate. The central hexameric 12 S subunit of the enzyme associates with six 6 S s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3095731551d14f8eae71d9dc4ab57246
https://doi.org/10.1016/s0021-9258(19)85436-4
https://doi.org/10.1016/s0021-9258(19)85436-4
Autor:
Andrei I. Khlebnikov, Olesya N Klubachuk, Choon-Soo Jeong, Sang B. Woo, Igor A. Schepetkin, Byoung S. Kwon, Shin Young Ah
Publikováno v:
Journal of agricultural and food chemistry. 51(18)
Mumie, a semihard black resin formed by long-term humification, is believed to have therapeutic properties. Although mumie has been used in folk medicine since ancient times, there is little information available concerning the physicochemical proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b74279f371efebc99d1f25465da847
https://pubmed.ncbi.nlm.nih.gov/12926866
https://pubmed.ncbi.nlm.nih.gov/12926866