Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Sanford M Simon"'
Autor:
Tsan-Wen Lu, Phillip C Aoto, Jui-Hung Weng, Cole Nielsen, Jennifer N Cash, James Hall, Ping Zhang, Sanford M Simon, Michael A Cianfrocco, Susan S Taylor
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001018 (2020)
When the J-domain of the heat shock protein DnaJB1 is fused to the catalytic (C) subunit of cAMP-dependent protein kinase (PKA), replacing exon 1, this fusion protein, J-C subunit (J-C), becomes the driver of fibrolamellar hepatocellular carcinoma (F
Externí odkaz:
https://doaj.org/article/764ecb3e6d3f4f3ea2fdf9f9c01927a8
Publikováno v:
eLife, Vol 9 (2020)
While the static structure of the nuclear pore complex (NPC) continues to be refined with cryo-EM and x-ray crystallography, in vivo conformational changes of the NPC remain under-explored. We developed sensors that report on the orientation of NPC c
Externí odkaz:
https://doaj.org/article/e6d49f23a922490a99a5b66405ed998e
Autor:
Kate Bredbenner, Sanford M Simon
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224697 (2019)
BackgroundJournals are trying to make their papers more accessible by creating a variety of research summaries including graphical abstracts, video abstracts, and plain language summaries. It is unknown if individuals with science, science-related, o
Externí odkaz:
https://doaj.org/article/4121ffbe2f074d79a2a9fcd104d8470b
Publikováno v:
eLife, Vol 7 (2018)
The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) proteins are critical for cellular membrane scission processes with topologies inverted relative to clathrin-mediated endocytosis. Some viruses appropriate ESCRT-IIIs for their re
Externí odkaz:
https://doaj.org/article/9588bebac7b74085adec9bccc738abac
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0196133 (2018)
We report a computational model for the assembly of HIV-1 Gag into immature viral particles at the plasma membrane. To reproduce experimental structural and kinetic properties of assembly, a process occurring on the order of minutes, a coarse-grained
Externí odkaz:
https://doaj.org/article/e5cb20d2acf648958ca2e31702b2dee1
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2416 (2008)
Members of the dynamin super-family of GTPases are involved in disparate cellular pathways. Dynamin1 and dynamin2 have been implicated in clathrin-mediated endocytosis. While some models suggest that dynamin functions specifically at the point of ves
Externí odkaz:
https://doaj.org/article/3e9e4144011f4e8e8edeb1736b025543
Autor:
Nolwenn Jouvenet, Stuart J D Neil, Cameron Bess, Marc C Johnson, Cesar A Virgen, Sanford M Simon, Paul D Bieniasz
Publikováno v:
PLoS Biology, Vol 4, Iss 12, p e435 (2006)
Recently proposed models that have gained wide acceptance posit that HIV-1 virion morphogenesis is initiated by targeting the major structural protein (Gag) to late endosomal membranes. Thereafter, late endosome-based secretory pathways are thought t
Externí odkaz:
https://doaj.org/article/02a5fc2643724f9d9e4c1095f0d00feb
Publikováno v:
PLoS Biology, Vol 2, Iss 8, p E233 (2004)
Synaptotagmin is considered a calcium-dependent trigger for regulated exocytosis. We examined the role of synaptotagmin VII (Syt VII) in the calcium-dependent exocytosis of individual lysosomes in wild-type (WT) and Syt VII knockout (KO) mouse embryo
Externí odkaz:
https://doaj.org/article/de467cfb6f6645388e84640a9c9bbd12
Autor:
Christoph Neumayer, Denise Ng, Caroline S. Jiang, Adam Qureshi, Gadi Lalazar, Roger Vaughan, Sanford M. Simon
Publikováno v:
Clin Cancer Res
Purpose: Gene fusions are drivers of many pediatric tumors. In fibrolamellar hepatocellular carcinoma (FLC), a fusion of DNAJB1 and PRKACA is the dominant recurrent mutation. Expression of the DNAJB1-PRKACA fusion gene in mice results in a tumor that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4992fa5b401c2752df8c7ee3f654aff6
https://doi.org/10.1158/1078-0432.ccr-22-1851
https://doi.org/10.1158/1078-0432.ccr-22-1851
Autor:
Sanford M. Simon, Michael V. Ortiz, Michael S. Torbenson, Philip Coffino, Anthony Letai, Charles M. Rice, Michael P. LaQuaglia, Hans-Guido Wendel, Tomoaki Kato, Faith Tierney, Rory L. Smoot, Mark J. Truty, Jennifer L. Leiting, Martin Hertl, Erik Schadde, Jessica Ellison, Barbara A. Lyons, J. Fraser Glickman, Ethan M. Weinberg, James A. Saltsman, William J. Hammond, Benjamin A. Farber, Arlene M. Hurley, Koen O.A. Vercauteren, Mohammad Kabbani, Eleftherios Michailidis, Solomon Levin, Bassem Shebl, Nicole J.C. Narayan, Ruisi Wang, Ype P. de Jong, Patrick D. Bhola, Denise Ng, Lavoisier Ramos-Espiritu, David Requena, Gadi Lalazar
To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents used clinically and inhibitors of oncogenes overexpressed in FLC showed little efficacy on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2e6eadd89b35c3fbc11103d986522f
https://doi.org/10.1158/2159-8290.c.6549037.v1
https://doi.org/10.1158/2159-8290.c.6549037.v1
