AZD1222 effectiveness against severe COVID-19 in individuals with comorbidity or frailty: The RAVEN cohort study.

Autor: Meeraus W; Medical Evidence, Vaccines & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK., Joy M; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Ouwens M; Medical & Payer Evidence Statistics, BioPharmaceuticals Medical, AstraZeneca, Mölndal, Sweden., Taylor KS; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Venkatesan S; Medical & Payer Evidence Statistics, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK., Dennis J; Momentum Data, St Albans, UK., Tran TN; Biopharmaceutical Medicine Respiratory and Immunology, AstraZeneca, Gaithersburg, MD, USA., Dashtban A; Institute of Health Informatics, University College London, London, UK., Fan X; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Williams R; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Morris T; Medical and Scientific Affairs, BioPharmaceuticals Medical, AstraZeneca, London, UK., Carty L; Medical & Payer Evidence Statistics, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK., Kar D; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Hoang U; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Feher M; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Forbes A; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Jamie G; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Hinton W; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Sanecka K; Medical Evidence, Vaccines & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Warsaw, Poland., Byford R; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Anand SN; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Hobbs FDR; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Clifton DA; Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK., Taylor S; Medical Evidence, Vaccines & Immune Therapies, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK., de Lusignan S; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK; Royal College of General Practitioners Research and Surveillance Centre, London, UK. Electronic address: simon.delusignan@phc.ox.ac.uk.

Publikováno v: The Journal of infection [J Infect] 2024 Apr; Vol. 88 (4), pp. 106129. Date of Electronic Publication: 2024 Feb 29.

Impaired iron recycling from erythrocytes is an early hallmark of aging.

Autor: Slusarczyk P; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Mandal PK; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Zurawska G; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Niklewicz M; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Chouhan K; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Mahadeva R; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Jończy A; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Macias M; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Szybinska A; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Cybulska-Lubak M; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Krawczyk O; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Herman S; Laboratory of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Cracow, Poland., Mikula M; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Serwa R; IMol Polish Academy of Sciences, Warsaw, Poland.; ReMedy International Research Agenda Unit, IMol Polish Academy of Sciences, Warsaw, Poland., Lenartowicz M; Laboratory of Genetics and Evolution, Institute of Zoology and Biomedical Research, Jagiellonian University, Cracow, Poland., Pokrzywa W; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland., Mleczko-Sanecka K; International Institute of Molecular and Cell Biology in Warsaw, Warsaw, Poland.

Publikováno v: ELife [Elife] 2023 Jan 31; Vol. 12. Date of Electronic Publication: 2023 Jan 31.

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Autor: Pasricha, S., Lim, P., Duarte, T., Casu, C., Oosterhuis, D., Mleczko-Sanecka, K., Suciu, M., Da Silva, A., Al-Hourani, K., Arezes, J., McHugh, K., Gooding, S., Frost, J., Wray, K., Santos, A., Porto, G., Repapi, E., Gray, N., Draper, S., Ashley, N., Soilleux, E., Olinga, P., Muckenthaler, M., Hughes, J., Rivella, S., Milne, T., Armitage, A., Drakesmith, H.

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications, 8:403. Nature Publishing Group

Hepcidin regulates systemic iron homeostasis. Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis. Here we show that epigenetic events govern h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3a577ab42681837e522023a5969b4483

Hepcidin Is a Valuable Therapeutic Target for Colorectal Cancer.

Autor: Frascatani, Rachele¹ (AUTHOR) rakfrasc@gmail.com, Colella, Marco¹ (AUTHOR) marco.colella.bio@gmail.com, Monteleone, Giovanni^1,2 (AUTHOR) gi.monteleone@med.uniroma2.it

Publikováno v: Cancers. Dec2024, Vol. 16 Issue 23, p4068. 10p.

Macrophage iron dyshomeostasis promotes aging‐related renal fibrosis.

Autor: Wu, Lingzhi¹ (AUTHOR), Lin, Hongchun¹ (AUTHOR), Li, Shaomin¹ (AUTHOR), Huang, Yuebo¹ (AUTHOR), Sun, Yuxiang¹ (AUTHOR), Shu, Shuangshuang¹ (AUTHOR), Luo, Ting¹ (AUTHOR), Liang, Tiantian¹ (AUTHOR), Lai, Weiyan¹ (AUTHOR), Rao, Jialing¹ (AUTHOR), Hu, Zhaoyong² (AUTHOR) zhaoyonh@bcm.edu, Peng, Hui^1,3 (AUTHOR) pengh@mail.sysu.edu.cn

Publikováno v: Aging Cell. Nov2024, Vol. 23 Issue 11, p1-17. 17p.