Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sandya R. Beeram"'
Autor:
Katarzyna B. Handing, Mateusz P. Czub, Kyungah Suh, Barat S. Venkataramany, Ivan G. Shabalin, Karolina A. Majorek, Przemyslaw J. Porebski, Wladek Minor, Ashley G. Woolfork, Sandya R. Beeram, David S. Hage
Publikováno v:
Chemical Science. 10:1607-1618
Serum albumin is the most abundant protein in mammalian blood plasma and is responsible for the transport of metals, drugs, and various metabolites, including hormones. We report the first albumin structure in complex with testosterone, the primary m
Publikováno v:
Methods. 146:46-57
A number of tools based on high-performance affinity separations have been developed for studying drug-protein interactions. An example of one recent approach is ultrafast affinity extraction. This method has been employed to examine the free (or non
Publikováno v:
J Chromatogr A
Many drugs bind to serum transport proteins, which can affect both drug distribution and activity in the body. α1-Acid glycoprotein (AGP) is a key transport protein for basic and neutral drugs. Both elevated levels and altered glycosylation patterns
Publikováno v:
Journal of Chromatography A. 1497:92-101
Interactions with serum proteins such as alpha1-acid glycoprotein (AGP) can have a significant effect on the behavior and pharmacokinetics of drugs. Ultrafast affinity extraction and peak profiling were used with AGP microcolumns to examine these pro
Publikováno v:
Drug Discovery Today: Technologies. 17:16-21
Information on the kinetics of drug-protein interactions is of crucial importance in drug discovery and development. Several methods based on affinity chromatography have been developed in recent years to examine the association and dissociation rate
Autor:
Allegra Pekarek, Tino Hofmann, Zhao Li, Elliott Rodriguez, Gianfranco Trovato, Sandya R. Beeram, Suresh Doddavenkatanna, Darin Peev, David S. Hage, Kathryn Goerl
Publikováno v:
Electrophoresis. 38(19)
The development of various nanomaterials over the last few decades has led to many applications for these materials in liquid chromatography (LC). This review will look at the types of nanomaterials that have been incorporated into LC systems and the
The binding of drugs with proteins and other agents in serum is of interest in personalized medicine because this process can affect the dosage and action of drugs. The extent of this binding may also vary with a given disease state. These interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b26dd09420d8ad9736bf1060bdc3150
https://doi.org/10.1016/bs.apcsb.2015.09.007
https://doi.org/10.1016/bs.apcsb.2015.09.007
Autor:
Erika L. Pfaunmiller, Ryan Matsuda, Christopher J. White, David S. Hage, Sandya R. Beeram, Zhao Li, Na Tasha Carter, Maria Podariu, Xiwei Zheng
Affinity chromatography has become an important tool for characterizing biomolecular interactions. The use of affinity microcolumns, which contain immobilized binding agents and have volumes in the mid-to-low microliter range, has received particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486dd0a8bb16e71db473ccec2761b940
https://europepmc.org/articles/PMC4112177/
https://europepmc.org/articles/PMC4112177/
Publikováno v:
Separations
The development of separation methods for the analysis and resolution of chiral drugs and solutes has been an area of ongoing interest in pharmaceutical research. The use of proteins as chiral binding agents in high-performance liquid chromatography