Výsledky vyhledávání - "Sandy R. Botros"

Akademický článek

Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1/Nrf2/NF-κB/TNF-α signaling pathways

Autor: Sandy R. Botros, Asmaa I. Matouk, Amr Amin, Gehan H. Heeba

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Introduction: Nephrotoxicity represents a major complication of using doxorubicin (DOX) in the management of several types of cancers. Increased oxidative stress and the activation of inflammatory mediators play outstanding roles in the development o

Externí odkaz: https://doaj.org/article/19d885e42bec45008bbfca4122bf4ee5

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Protective effect of empagliflozin on gentamicin-induced acute renal injury via regulation of SIRT1/NF-κB signaling pathway

Autor: Sandy R. Botros, Asmaa I. Matouk, Aliaa Anter, Mohamed M.A. Khalifa, Gehan H. Heeba

Publikováno v: Environmental Toxicology and Pharmacology. 94:103907

Gentamicin is a highly effective antibiotic. However, its major complication is nephrotoxicity. This study investigated the beneficial effects of empagliflozin against gentamicin-induced nephropathy. Kidney damage was induced in male Wistar rats by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f15d124f919ab05767d3162f681a46c4
https://doi.org/10.1016/j.etap.2022.103907

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