Zobrazeno 1 - 10
of 1 177
pro vyhledávání: '"Sandy R"'
Autor:
Lauren P. Giesler, William T. O'Brien, Georgia F. Symons, Sabrina Salberg, Gershon Spitz, Robb Wesselingh, Terence J. O'Brien, Richelle Mychasiuk, Sandy R. Shultz, Stuart J. McDonald
Publikováno v:
Neurotrauma Reports, Vol 5, Iss 1, Pp 74-80 (2024)
Traumatic brain injuries (TBIs) and concussions are prevalent in collision sports, and there is evidence that levels of exposure to such sports may increase the risk of neurological abnormalities. Elevated levels of fluid-based biomarkers have been o
Externí odkaz:
https://doaj.org/article/12b7caa5a7f249388a0e051cc18bdca7
Autor:
Georgia F. Symons, Matthew C. Gregg, Amelia J. Hicks, Christopher C. Rowe, Sandy R. Shultz, Jennie L. Ponsford, Gershon Spitz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Traumatic brain injury (TBI) alters brain network connectivity. Structural covariance networks (SCNs) reflect morphological covariation between brain regions. SCNs may elucidate how altered brain network topology in TBI influences long-term
Externí odkaz:
https://doaj.org/article/3992c5f58f674c02a52df5b57e01b810
Autor:
Tamara L. Baker, David K. Wright, Alessandro D. Uboldi, Christopher J. Tonkin, Anh Vo, Trevor Wilson, Stuart J. McDonald, Richelle Mychasiuk, Bridgette D. Semple, Mujun Sun, Sandy R. Shultz
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-31 (2024)
Abstract Traumatic brain injury (TBI) is a key contributor to global morbidity that lacks effective treatments. Microbial infections are common in TBI patients, and their presence could modify the physiological response to TBI. It is estimated that o
Externí odkaz:
https://doaj.org/article/dd19e4fc213b4406a1fdbe90f4f928eb
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Nephrotoxicity represents a major complication of using doxorubicin (DOX) in the management of several types of cancers. Increased oxidative stress and the activation of inflammatory mediators play outstanding roles in the development o
Externí odkaz:
https://doaj.org/article/19d885e42bec45008bbfca4122bf4ee5
Autor:
Patricia G. Saletti, Wenzhu B. Mowrey, Wei Liu, Qianyun Li, Jesse McCullough, Roxanne Aniceto, I‐Hsuan Lin, Michael Eklund, Pablo M. Casillas‐Espinosa, Idrish Ali, Cesar Santana‐Gomez, Lisa Coles, Sandy R. Shultz, Nigel Jones, Richard Staba, Terence J. O'Brien, Solomon L. Moshé, Denes V. Agoston, Aristea S. Galanopoulou, for the EpiBioS4Rx Study Group
Publikováno v:
Epilepsia Open, Vol 8, Iss 2, Pp 586-608 (2023)
Abstract Objective We used the lateral fluid percussion injury (LFPI) model of moderate‐to‐severe traumatic brain injury (TBI) to identify early plasma biomarkers predicting injury, early post‐traumatic seizures or neuromotor functional recover
Externí odkaz:
https://doaj.org/article/0fa6ea6ae33d4d8783473bb3574a6e08
Autor:
Lucy Vivash, Dennis Velakoulis, Patrick Carney, Patrick Kwan, Leonid Churilov, Terence J O’Brien, Christopher M Hovens, Nicholas Lawn, Piero Perucca, Sandy R Shultz, John-Paul Nicolo, Charles Malpas, Manori Wijayath, David Reutens, Hannah Johns, Sara MacPhail, Pablo Casillas-Espinosa, Chris Tailby, Lisa Gillinder
Publikováno v:
BMJ Open, Vol 13, Iss 10 (2023)
Introduction Epilepsy is one of the most common neurological conditions worldwide. Despite many antiseizure medications (ASMs) being available, up to one-third of patients do not achieve seizure control. Preclinical studies have shown treatment with
Externí odkaz:
https://doaj.org/article/3fd64e9e8e8b4ff9b7e3d63e337655c5
Autor:
Frances Corrigan, Alina Arulsamy, Sandy R. Shultz, David K. Wright, Lyndsey E. Collins-Praino
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 41-50 (2023)
Traumatic brain injury (TBI) is associated with persistent impairments in multiple domains, including cognitive and neuropsychiatric function. Previous literature has suggested that the risk of such impairments may differ as a function of the initial
Externí odkaz:
https://doaj.org/article/bb55f13c94134f78a15e88b06b4d186a
Autor:
Sandy R. Shultz, Anup D. Shah, Cheng Huang, Larissa K. Dill, Ralf B. Schittenhelm, M. Cristina Morganti-Kossmann, Bridgette D. Semple
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract The pathophysiology of traumatic brain injury (TBI) requires further characterization to fully elucidate changes in molecular pathways. Cerebrospinal fluid (CSF) provides a rich repository of brain-associated proteins. In this retrospective
Externí odkaz:
https://doaj.org/article/c518ef4f923d4b8e99768f221f3751f2
Autor:
Josh Allen, Louise Pham, Simon T. Bond, William T. O’Brien, Gershon Spitz, Sandy R. Shultz, Brian G. Drew, David K. Wright, Stuart J. McDonald
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionMild traumatic brain injuries (mTBIs) are the most common form of acquired brain injury. Symptoms of mTBI are thought to be associated with a neuropathological cascade, potentially involving the dysregulation of neurometabolites, lipids,
Externí odkaz:
https://doaj.org/article/7adb297148da47d298204a3936049e59
Autor:
Pablo M Casillas-Espinosa, Alison Anderson, Anna Harutyunyan, Crystal Li, Jiyoon Lee, Emma L Braine, Rhys D Brady, Mujun Sun, Cheng Huang, Christopher K Barlow, Anup D Shah, Ralf B Schittenhelm, Richelle Mychasiuk, Nigel C Jones, Sandy R Shultz, Terence J O'Brien
Publikováno v:
eLife, Vol 12 (2023)
There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal lobe epilepsy (TLE). This study aimed to evaluate for disease modifying effects of sodium sel
Externí odkaz:
https://doaj.org/article/4e8722171a41474ebb674b4e800efafa