A novel read methodology to evaluate the optimal dose of 68Ga-satoreotide trizoxetan as a PET imaging agent in patients with gastroenteropancreatic neuroendocrine tumours: a phase II clinical trial

Autor: Colin G. Miller, Henning Grønbæk, Irene Virgolini, Andreas Kjaer, Pierre Terve, Shadfar Bahri, Peter Iversen, Hanna Svirydenka, Thomas Rohban, Sandy McEwan

Publikováno v: EJNMMI Research, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Background 68Ga-satoreotide trizoxetan is a novel somatostatin receptor antagonist exhibiting higher tumour-to-background ratios and sensitivity compared to 68Ga-DOTATOC. This randomised, 2 × 3 factorial, phase II study aimed to confirm the

Externí odkaz: https://doaj.org/article/4c8b1bb0808c480fadaf97e8afe9d6a7

A Randomized, Factorial Phase II Study to Determine the Optimal Dosing Regimen for 68Ga-Satoreotide Trizoxetan as an Imaging Agent in Patients with Gastroenteropancreatic Neuroendocrine Tumors

Autor: Ulrich Knigge, Shadfar Bahri, Johannes Czernin, Peter Iversen, Andreas Kjaer, Esben Andreas Carlsen, Christine Powell, Johanna Maffey-Steffan, Henning Grønbæk, Irene Virgolini, Sandy McEwan, Colin G. Miller, Mathias Loft, Thomas Rohban

Publikováno v: Virgolini, I, Bahri, S, Kjaer, A, Gronbaek, H, Iversen, P, Carlsen, E A, Loft, M, Knigge, U, Maffey-Steffan, J, Powell, C, Miller, C G, Rohban, T, McEwan, S & Czernin, J 2022, ' A Randomized, Factorial Phase II Study to Determine the Optimal Dosing Regimen for 68 Ga-Satoreotide Trizoxetan as an Imaging Agent in Patients with Gastroenteropancreatic Neuroendocrine Tumors ', Journal of Nuclear Medicine, vol. 63, no. 3, pp. 376-383 . https://doi.org/10.2967/jnumed.121.261936
Virgolini, I, Bahri, S, Kjaer, A, Gronbaek, H, Iversen, P, Carlsen, E A, Loft, M, Knigge, U, Maffey-Steffan, J, Powell, C, Miller, C G, Rohban, T, McEwan, S & Czernin, J 2022, ' A randomised, factorial phase II study to determine the optimal dosing regimen for 68 Ga-satoreotide trizoxetan as an imaging agent in patients with gastroenteropancreatic neuroendocrine tumours ', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 63, no. 3 . https://doi.org/10.2967/jnumed.121.261936

68Ga-satoreotide trizoxetan is a novel somatostatin receptor antagonist associated with high sensitivity and reproducibility in neuroendocrine tumour (NET) detection and localisation. However, the optimal peptide mass and radioactivity ranges for 68G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46b7d8b3fed34544124a81cf18e8ced
https://pure.au.dk/portal/da/publications/a-randomized-factorial-phase-ii-study-to-determine-the-optimal-dosing-regimen-for-68gasatoreotide-trizoxetan-as-an-imaging-agent-in-patients-with-gastroenteropancreatic-neuroendocrine-tumors(efd7ada3-d130-4069-aa7e-652d008e0f37).html

Low-Activity Radioactive Iodine Therapy for Thyroid Carcinomas Exhibiting Nodal Metastases and Extrathyroidal Extension May Lead to Early Disease Recurrence

Autor: Sarah Baker, Julianna Zenke, Don Morrish, Diane Severin, A.J.B. Sandy McEwan, Todd P. W. McMullen, Ahmed Morad, Sunita Ghosh, Karen P. Chu, David Williams

Publikováno v: Thyroid. 28:902-912

The application of radioactive iodine in differentiated thyroid carcinomas has become more selective in an attempt to decrease morbidity. While ablative success has been documented, it is less clear how changes in radioactive iodine treatment strateg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf1a9d2b6de1804262cfd7f8b1bbb21
https://doi.org/10.1089/thy.2017.0136

Poster - Thur Eve - 03: Application of the non-negative matrix factorization technique to [11 C]-DTBZ dynamic PET data for the early detection of Parkinson's disease

Autor: Hans Jans, Dong-Chang Lee, Sandy McEwan, W.R. Wayne Martin, T. Riauka, Marguerite Wieler

Publikováno v: Medical Physics. 41:7-7

In this work, a class of non-negative matrix factorization (NMF) technique known as alternating non-negative least squares, combined with the projected gradient method, is used to analyze twenty-five [11C]-DTBZ dynamic PET/CT brain data. For each sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e8fe463f7948404d9c38f6bb5fe5f7b
https://doi.org/10.1118/1.4894989