Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sandy Koppenol"'
Autor:
Kamal D. Puri, Carmen Ip, Adam Kashishian, Gary Phillips, Sandy Koppenol, Musong Kim, Jennifer Treiberg, Armando G. Villaseñor, Jayaraman Chandrasekhar, Stephane Perreault, Kristen Forseth, Leena Patel, Mary E. McGrath, Bart H. Steiner, Joseph Therrien, John R. Somoza, Aaron C. Haran, David Koditek, Latesh Lad, Eve-Irene Lepist, Jerry Evarts
Publikováno v:
Journal of medicinal chemistry. 59(19)
Aberrant signaling of phosphoinositide 3-kinase δ (PI3Kδ) has been implicated in numerous pathologies including hematological malignancies and rheumatoid arthritis. Described in this manuscript are the discovery, optimization, and in vivo evaluatio
Autor:
Masahiko Hara, Noah Malmstadt, Patrick S. Stayton, Todd C. Edwards, Viola Vogel, Sandy Koppenol
Publikováno v:
Langmuir. 18:7447-7451
The two-dimensional crystallization of the protein streptavidin under biotinylated lipids has provided a convenient model system for studying the molecular mechanisms underlying protein crystallization. At neutral pH, streptavidin forms crystals with
Autor:
Channing R. Robertson, Szu Wen Wang, Sandy Koppenol, Patrick S. Stayton, Alice P. Gast, Viola Vogel, Todd Edwards
Publikováno v:
Langmuir. 16:5199-5204
The carboxyl- and amino-terminal ends of streptavidin are near the site of protein−protein contacts in two-dimensional streptavidin crystals. The role of these C- and N-terminal residues in determining the pH-dependent phase behavior of crystalliza
Autor:
Viola Vogel, Patrick S. Stayton, Wolfgang Frey, Todd C. Edwards, William R. Schief, Sandy Koppenol, Ronald E. Stenkamp
Publikováno v:
Langmuir. 14:4683-4687
The two-dimensional crystallization of streptavidin at functionalized lipid interfaces is one of the best studied model systems for investigating molecular self-assembly processes. This system also provides an opportunity to elucidate the relationshi
Publikováno v:
Journal of Colloid and Interface Science. 189:158-166
In the context of understanding the properties of model lung surfactant systems, surface phase behavior of spread monolayers containing mixtures of dipalmitoylphosphatidylcholine (DPPC), with various unsaturated phosphatidylcholine (PC) and phosphati
Autor:
Sandy Koppenol, Paul M. Bummer
Publikováno v:
ChemInform. 32
Publikováno v:
International Journal of Pharmaceutics. 84:261-271
Desiccants are frequently included in moisture-sensitive solid pharmaceutical products to scavenge moisture in the package and prevent this water from interacting with the product. This study has demonstrated the utility of the sorption-desorption mo
Autor:
Sandy Koppenol
Publikováno v:
Protein Formulation and Delivery ISBN: 9780429134548
This section considers the physical stability of the peptide or protein including conformational changes, aggregation, and adsorption. The physical stability of the protein, and thus protein function, can be affected by a number of environmental para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e10f97ca61b3d162a6b820b412d1db5
https://doi.org/10.3109/9780849379529-6
https://doi.org/10.3109/9780849379529-6
Publikováno v:
Biochimica et biophysica acta. 1369(2)
Lung annexin I (LAI), a calcium-ion-dependent phospholipid-binding protein, has been shown earlier to cause aggregation and fusion of bilayered vesicles containing phospholipids found in lung surfactant, and to be a very likely factor in the assembly
We report on the surface behavior of a hydrophobic, cationic peptide, [lysine-(leucine)4]4-lysine (KL4), spread at the air/water interface at 25 degrees C and pH 7.2, and its effect at very low molar ratios on the surface properties of the zwitterion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c43b8e336470701f534182c488972af
https://europepmc.org/articles/PMC1299533/
https://europepmc.org/articles/PMC1299533/