Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sandy ElSayed"'
Autor:
Marwa Qadri, Zenat Khired, Reem Alaqi, Sandy Elsayed, Abdulaziz Alarifi, Rayan Ahmed, Hussain Alhamami, Amani Khardali, Walaa Hakami
Publikováno v:
Saudi Pharmaceutical Journal, Vol 32, Iss 3, Pp 101956- (2024)
Hyperuricemia contributes significantly to gout arthritis pathogenesis, which promotes urate crystal deposition in the joints and activates joint-resident macrophages and circulating monocytes to initiate a state of inflammatory arthritis. In the joi
Externí odkaz:
https://doaj.org/article/b844bc89d97846d2b55112d23e419bc1
Autor:
Sandy Elsayed, Khaled A. Elsaid
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Gout is a common arthritis, due to deposition of monosodium urate (MSU) crystals which results in IL-1β secretion by tissue-resident macrophages. Xanthine oxidase (XO) catalyzes uric acid (UA) production and in the process, reactive oxyg
Externí odkaz:
https://doaj.org/article/232724946b0244cea70b3e08ca62f8b9
Autor:
Sandy ElSayed, Gregory D. Jay, Ralph Cabezas, Marwa Qadri, Tannin A. Schmidt, Khaled A. Elsaid
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
ObjectivesTo compare phagocytic activities of monocytes in peripheral blood mononuclear cells (PBMCs) from acute gout patients and normal subjects, examine monosodium urate monohydrate (MSU) crystal-induced IL-1β secretion ± recombinant human prote
Externí odkaz:
https://doaj.org/article/a5f5059e5b304849a44c791b529ffdcc
Autor:
Khaled Elsaid, Tony R. Merriman, Leigh‐Ana Rossitto, Ru Liu‐Bryan, Jacob Karsh, Amanda Phipps‐Green, Gregory D. Jay, Sandy Elsayed, Marwa Qadri, Marin Miner, Murray Cadzow, Talia J. Dambruoso, Tannin A. Schmidt, Nicola Dalbeth, Ashika Chhana, Jennifer Höglund, Majid Ghassemian, Anaamika Campeau, Nancy Maltez, Niclas G. Karlsson, David J. Gonzalez, Robert Terkeltaub
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.).
In gout, hyperuricemia promotes urate crystal deposition that stimulates the NLRP3 inflammasome and IL-1β-mediated arthritis. Incident gout without background hyperuricemia is rarely reported. To identify hyperuricemia-independent mechanisms driving
Autor:
Khaled A. Elsaid, Gregory D. Jay, Tannin A. Schmidt, Marwa Qadri, Sandy Elsayed, Ralph Cabezas
Publikováno v:
The FASEB Journal. 35
Publikováno v:
J Pharmacol Exp Ther
Gout is a chronic inflammatory arthritis caused by monosodium urate monohydrate (MSU) crystal deposits in joints of lower limbs. Phagocytic uptake of MSU crystals by joint-resident macrophages and recruited circulating monocytes results in IL-1β exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9019b0ed9c1141b408adb03d293d36dd
https://europepmc.org/articles/PMC7873533/
https://europepmc.org/articles/PMC7873533/
Publikováno v:
The FASEB Journal. 34:1-1