Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Sandy D Westerheide"'
Autor:
Trillitye Paullin, Chase Powell, Christopher Menzie, Robert Hill, Feng Cheng, Christopher J Martyniuk, Sandy D Westerheide
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182930 (2017)
Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. These poor statistics are related to a lack of early symptoms and inadequate screening techniques. This
Externí odkaz:
https://doaj.org/article/dec39571b27b40abafc008cc4c9d664f
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183445 (2017)
The ability of an organism to sense and adapt to environmental stressors is essential for proteome maintenance and survival. The highly conserved heat shock response is a survival mechanism employed by all organisms, including the nematode Caenorhabd
Externí odkaz:
https://doaj.org/article/5c0c983c549844acbd1944bd55e49bf8
Autor:
Chase D Powell, Trillitye R Paullin, Candice Aoisa, Christopher J Menzie, Ashley Ubaldini, Sandy D Westerheide
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168389 (2016)
Ovarian cancer is the most lethal gynecological cancer, with over 200,000 women diagnosed each year and over half of those cases leading to death. The proteotoxic stress-responsive transcription factor HSF1 is frequently overexpressed in a variety of
Externí odkaz:
https://doaj.org/article/2423c392b43f484f8ad85587364e2371
Autor:
Rachel Raynes, Kathleen M Pombier, Kevin Nguyen, Jessica Brunquell, Jamie E Mendez, Sandy D Westerheide
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54364 (2013)
The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce
Externí odkaz:
https://doaj.org/article/da6a524702184b09a73f13621b022247
Autor:
Aurélie de Thonel, Johanna K. Ahlskog, Kevin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C. Puustinen, Federico Miozzo, Patricia Fergelot, Élise Lebigot, Alain Verloes, Pierre Gressens, Didier Lacombe, Jessica Gobbo, Carmen Garrido, Sandy D. Westerheide, Laurent David, Michel Petitjean, Olivier Taboureau, Fernando Rodrigues-Lima, Sandrine Passemard, Délara Sabéran-Djoneidi, Laurent Nguyen, Madeline Lancaster, Lea Sistonen, Valérie Mezger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4589c26879ce46d1a03bf9df8d0e1d72
Autor:
Aurélie de Thonel, Johanna K. Ahlskog, Kevin Daupin, Véronique Dubreuil, Jérémy Berthelet, Carole Chaput, Geoffrey Pires, Camille Leonetti, Ryma Abane, Lluís Cordón Barris, Isabelle Leray, Anna L. Aalto, Sarah Naceri, Marine Cordonnier, Carène Benasolo, Matthieu Sanial, Agathe Duchateau, Anniina Vihervaara, Mikael C. Puustinen, Federico Miozzo, Patricia Fergelot, Élise Lebigot, Alain Verloes, Pierre Gressens, Didier Lacombe, Jessica Gobbo, Carmen Garrido, Sandy D. Westerheide, Laurent David, Michel Petitjean, Olivier Taboureau, Fernando Rodrigues-Lima, Sandrine Passemard, Délara Sabéran-Djoneidi, Laurent Nguyen, Madeline Lancaster, Lea Sistonen, Valérie Mezger
Publikováno v:
Nature Communications. 13
Patients carrying autosomal dominant mutations in the histone/lysine acetyl transferases CBP or EP300 develop a neurodevelopmental disorder: Rubinstein-Taybi syndrome (RSTS). The biological pathways underlying these neurodevelopmental defects remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460400ee624230ee27172c4e0eaa5885
https://doi.org/10.1038/s41467-022-34476-2
https://doi.org/10.1038/s41467-022-34476-2
Publikováno v:
Cell Stress Chaperones
The transcription factor heat shock factor-1 (HSF-1) regulates the heat shock response (HSR), a cytoprotective response induced by proteotoxic stresses. Data from model organisms has shown that HSF-1 also has non-stress biological roles, including ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ae1378702a98e606a617537ff39416
https://doi.org/10.1007/s12192-020-01188-9
https://doi.org/10.1007/s12192-020-01188-9
Publikováno v:
Frontiers in Aging. 3
The decline of proteostasis is a hallmark of aging that is, in part, affected by the dysregulation of the heat shock response (HSR), a highly conserved cellular response to proteotoxic stress in the cell. The heat shock transcription factor HSF-1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75d60cdf350646e9f372aaa8cb7ffaf9
https://doi.org/10.3389/fragi.2022.861761
https://doi.org/10.3389/fragi.2022.861761
1.ABSTRACTThe Cell Division Cycle and Apoptosis Regulator (CCAR) protein family members are putative transcription regulators that have been characterized for modulating the cell cycle, apoptosis, metabolism, and the heat shock response. Mammals have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46cfd854d511f026aa7359f31c1a44a2
https://doi.org/10.1101/2021.07.06.451293
https://doi.org/10.1101/2021.07.06.451293
Autor:
Jennifer B. Permuth, Margaret A. Park, Christina J. Moss, Anika N. Ali, Charles E. Chalfant, Sandy D. Westerheide, Sean P. Lund, Emily M. Mayo, Gina S. Nazario-Muñoz, Shaun C. Stevens
HIF1 (Hypoxia-inducible Factor 1) is a transcription factor that plays a crucial role in the hypoxia stress response. Its primary function is to return the cell to its homeostatic state following oxygen deprivation. However, chronic hypoxia exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48342704c1e04accc4deb692ff3dfe98
https://doi.org/10.1101/2020.10.05.325290
https://doi.org/10.1101/2020.10.05.325290