Výsledky vyhledávání - "Sandy, Livingston"

Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression

Autor: Sandy Livingston, Craig A. Beam, Marek Wloch, Nills Diaz, Richard Jove, Tammy Bowman, Ibrahim Eweis, Susan Minton, Carlos A. Muro-Cacho, Ed Seijo, Roy Garcia, Charles E. Cox, Alan B. Cantor, Daniel M. Sullivan, Ji-Hyun Lee, Tanya Gritsko

Publikováno v: Clinical Cancer Research. 12:20-28

Purpose: Constitutive activation of signal transducer and activator of transcription 3 (Stat3) protein has been observed in a wide variety of tumors, including breast cancer, and contributes to oncogenesis at least in part by prevention of apoptosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107207f95737acd0912c4b8a53364633
https://doi.org/10.1158/1078-0432.ccr-04-1749

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Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells

Autor: Sandy Livingston, Domenico Coppola, Eric B. Haura, W. Douglas Cress, Lanxi Song

Publikováno v: Cancer Biology & Therapy. 4:267-276

Overexpression of anti-apoptotic Bcl-2 family members and deregulation of the pathways that regulate pro-apoptotic family members have been observed in non-small cell lung cancers (NSCLC). Previous reports have identified both Bcl-2 and Bcl-x(L) prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d06b1e606c309179fb1a5a10907e25
https://doi.org/10.4161/cbt.4.3.1496

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Autocrine interleukin-6/interleukin-6 receptor stimulation in non-small-cell lung cancer

Autor: Sandy Livingston, Domenico Coppola, Eric B. Haura

Publikováno v: Clinical lung cancer. 7(4)

Autocrine growth factor stimulation resulting in growth self-sufficiency is a hallmark of cancer. Classically, non–small-cell lung cancer (NSCLC) cells have autocrine epidermal growth factor stimulation through coexpression of receptors and ligands

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7644cfb8c8c0c9991602906c6de74b9
https://pubmed.ncbi.nlm.nih.gov/16512982

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Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells

Autor: Linda B, Mora, Ralf, Buettner, John, Seigne, Jose, Diaz, Nazeel, Ahmad, Roy, Garcia, Tammy, Bowman, Robert, Falcone, Rita, Fairclough, Alan, Cantor, Carlos, Muro-Cacho, Sandy, Livingston, James, Karras, Julio, Pow-Sang, Richard, Jove

Publikováno v: Cancer research. 62(22)

Signal transducers and activators of transcription (STATs) were identified originally as key components of cytokine signaling pathways. More recently, constitutive activation of STAT proteins has been detected in a wide variety of human tumor specime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8380dd324de790834e5bedcb1eaf380e
https://pubmed.ncbi.nlm.nih.gov/12438264

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