Spontaneously occurring cardiovascular lesions in commonly used laboratory animals

Autor: Eugene Herman, Sandy Eldridge

Publikováno v: Cardio-Oncology, Vol 5, Iss 1, Pp 1-8 (2019)

Abstract The search for new chemical entities which are clinically effective and do not adversely affect the cardiovascular system is an ongoing objective. In vivo studies designed to detect potential drug-induced cardiovascular toxicity typically ut

Externí odkaz: https://doaj.org/article/c5ae1100b54a422a809a6bb5e0b9da10

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Autor: Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Alexandre J. S. Ribeiro, Tanja Zabka, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclini

Externí odkaz: https://doaj.org/article/e6b42e00ab1d407c9c50c66883fb0686

Supplemental Methods from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Autor: Christine M. Heske, Leonard M. Neckers, Victor Darley-Usmar, Matthew D. Hall, Murali C. Krishna, Gordon M. Stott, Lee J. Helman, Mioara Larion, Jack F. Shern, Arnulfo Mendoza, Adrian Lita, Victor Ruiz-Rodado, Tyrone Dowdy, John Hamre, Sandy Eldridge, Haiyan Lei, Marielle E. Yohe, Giuseppe L. Squadrito, Gloria A. Benavides, Michelle S. Johnson, Daniel J. Urban, Ganesha Rai, Leah D. Edessa, Joshua T. Baumgart, Nobu Oshima, Sameer H. Issaq, Anna E. Gibson, Choh Yeung

A description of additional supplemental methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a582cfc30e75e1f35dbfbe55d3f2fd
https://doi.org/10.1158/0008-5472.22422704

Data from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Autor: Christine M. Heske, Leonard M. Neckers, Victor Darley-Usmar, Matthew D. Hall, Murali C. Krishna, Gordon M. Stott, Lee J. Helman, Mioara Larion, Jack F. Shern, Arnulfo Mendoza, Adrian Lita, Victor Ruiz-Rodado, Tyrone Dowdy, John Hamre, Sandy Eldridge, Haiyan Lei, Marielle E. Yohe, Giuseppe L. Squadrito, Gloria A. Benavides, Michelle S. Johnson, Daniel J. Urban, Ganesha Rai, Leah D. Edessa, Joshua T. Baumgart, Nobu Oshima, Sameer H. Issaq, Anna E. Gibson, Choh Yeung

Altered cellular metabolism, including an increased dependence on aerobic glycolysis, is a hallmark of cancer. Despite the fact that this observation was first made nearly a century ago, effective therapeutic targeting of glycolysis in cancer has rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c638e7e898ab42ee2c034b03b4c18032
https://doi.org/10.1158/0008-5472.c.6511316.v1

Contributors

Autor: Rick Adler, Famke Aeffner, Laura E. Armstrong, Dmitri Artemov, Adam D. Aulbach, Bindu M. Bennet, Eric A. Blomme, Brad Bolon, Christopher J. Bowman, Molly Boyle, Alys Bradley, Dino Bradley, Danielle Brown, Pierre R. Bushel, Ellen Cannady, Mark F. Cesta, Curtis Chan, Jennifer A. Chilton, Peter J.M. Clements, Torrie A. Crabbs, Myrtle A. Davis, Sandy Eldridge, Daniela Ennulat, Jeffrey Everitt, Isabel Figueroa, James D. Fikes, Thomas Forest, Catherine A. Foss, John R. Foster, Kathleen Gabrielson, Shayne C. Gad, Kapil Gadkar, Jinping Gan, David Garcia-Tapia, Frank J. Geoly, Wendy G. Halpern, Jerry F. Hardisty, Wanda M. Haschek, Kathleen Marie Heinz-Taheny, Kristi Helke, Lauren E. Himmel, Mark J. Hoenerhoff, Jennifer L. Ingram–Ross, Armando R. Irizarry Rovira, Evan B. Janovitz, Kishore Katyayan, Charlotte M. Keenan, Angela King-Herbert, Steven T. Laing, Lois D. Lehman-McKeeman, Na Li, Calvert Louden, Claire Lyons, Kevin McDorman, Elizabeth McInnes, Lyn Miller Wancket, Sheroy Minocherhomji, Sébastien Monette, James Morrison, Vasanthi Mowat, Sydney Mukaratirwa, Keith Nelson, Arun R. Pandiri, Tracey Papenfuss, Nita Patel, Daniel J. Patrick, Shari A. Price, Deepa B. Rao, James T. Raymond, Jennifer Rojko, Colin G. Rousseaux, Sara F. Santagostino, Aaron Sargeant, Christina Satterwhite, A. Eric Schultze, Vanessa Schumacher, Cheryl Scudamore, Keith R. Shockley, Bhanu P. Singh, David M. Stresser, Polina Sysa-Shah, Debra A. Tokarz, Terry Van Vleet, Matthew A. Wallig, Jin Wang, Cynthia J. Willson, Kristin Lewis Wilson, Christopher T. Winkelmann, Jeffrey C. Wolf, Charles Wood, Daniela Bumbaca Yadav, Mark Zarella

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3831ed61c4599a4d47034bfb7e19d99
https://doi.org/10.1016/b978-0-12-821044-4.01002-5