Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites

Autor: Esther Rajendran, Sanduni V. Hapuarachchi, Catherine M. Miller, Stephen J. Fairweather, Yeping Cai, Nicholas C. Smith, Ian A. Cockburn, Stefan Bröer, Kiaran Kirk, Giel G. van Dooren

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Apicomplexans are parasites that use membrane transporters to scavenge essential nutrients from the host. Here the authors identify and characterize two apicomplexans transporters showing that these are crucial for cationic amino acid uptake, parasit

Externí odkaz: https://doaj.org/article/af9f4f91b04841bdb2ffbb97deef1228

Protein kinase A negatively regulates Ca2+ signalling in Toxoplasma gondii

Autor: Rebecca Stewart, Laura F. Dagley, Sanduni V. Hapuarachchi, Malcolm J. McConville, Cyrille Y. Botté, Alessandro D. Uboldi, Luning Yang, Nicholas J. Katris, Ross F. Waller, Adele M. Lehane, Christopher J. Tonkin, Michael J Coffey, Mary-Louise Wilde, Emi A. McRae, Andrew I. Webb

Publikováno v: PLoS Biology
PLoS Biology, Public Library of Science, 2018, 16 (9), pp.e2005642. ⟨10.1371/journal.pbio.2005642⟩
PLoS Biology, Vol 16, Iss 9, p e2005642 (2018)
PLoS Biology, 2018, 16 (9), pp.e2005642. ⟨10.1371/journal.pbio.2005642⟩

The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating stages and actively motile extracellular forms that move through tissue. Parasite cytosolic Ca2+ signalling activates motili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ba262a42a186d9210241c1794159a6
https://www.hal.inserm.fr/inserm-02139070

The Dark Side of the Chloroplast: Biogenesis, Metabolism and Membrane Biology of the Apicoplast

Autor: Giel G. van Dooren, Sanduni V. Hapuarachchi

Members of the phylum Apicomplexa contain plastids, termed apicoplasts, that were derived by secondary endosymbiosis. Unlike most of their sun-loving cousins, apicomplexans are parasites that live in the dark recesses of the animal hosts they infect.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4368a62805d4752bb68d810eda00a7d7
https://doi.org/10.1016/bs.abr.2017.06.007

Substrate-Analogous Inhibitors Exert Antimalarial Action by Targeting the Plasmodium Lactate Transporter PfFNT at Nanomolar Scale

Autor: Adelaide S. M. Dennis, Rowena E. Martin, Kiaran Kirk, Sarah H. Shafik, Sanduni V. Hapuarachchi, Simon A. Cobbold, Adele M. Lehane, Malcolm J. McConville

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 2, p e1006180 (2017)

In this study the ‘Malaria Box’ chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH of the malaria parasite, Plasmodium falciparum. Fifteen compounds induced an acidificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938a548ecafa05c100792fe8bd85ee48
https://doi.org/10.1371/journal.ppat.1006180

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens.

Autor: Sanduni V Hapuarachchi, Simon A Cobbold, Sarah H Shafik, Adelaide S M Dennis, Malcolm J McConville, Rowena E Martin, Kiaran Kirk, Adele M Lehane

Publikováno v: PLoS Pathogens, Vol 13, Iss 2, p e1006180 (2017)

In this study the 'Malaria Box' chemical library comprising 400 compounds with antiplasmodial activity was screened for compounds that perturb the internal pH of the malaria parasite, Plasmodium falciparum. Fifteen compounds induced an acidification

Externí odkaz: https://doaj.org/article/af29320f19f24b8b9d2b5dfd5482a5da