Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sandt, J.J.M. van de"'
Autor:
Jong, E. de, Louisse, J., Verwei, M., Blaauboer, B.J., Sandt, J.J.M. van de, Woutersen, R.A., Rietjens, I.M.C.M., Piersma, A.H.
Publikováno v:
Toxicological Sciences, 1, 110, 117-124
The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::22d0d1039d5aeb19281815a379ab662e
https://dspace.library.uu.nl/handle/1874/39323
https://dspace.library.uu.nl/handle/1874/39323
Publikováno v:
Regulatory Toxicology and Pharmacology, 3, 54, 221-228
Quantification of skin absorption is an essential step in reducing the uncertainty of dermal risk assessment. Data from literature indicate that the relative dermal absorption of substances is dependent on dermal loading. Therefore, an internal expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::977f62753d8e8ac5cc046842f1e7975d
http://resolver.tudelft.nl/uuid:e9ae718f-3254-471d-8fab-03aa4052f1f6
http://resolver.tudelft.nl/uuid:e9ae718f-3254-471d-8fab-03aa4052f1f6
Publikováno v:
Current Drug Metabolism, 8, 8, 758-772
In this review, we discuss and compare studies of xenobiotic metabolism in both human skin and 3D human skin reconstructs. In comparison to the liver, the skin is a less studied organ in terms of characterising metabolic capability. While the skin fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6e09aff4fa6aa358b151d7d24299cfcf
http://resolver.tudelft.nl/uuid:2cd94baf-d34f-4d61-8f29-6cc67dcef31f
http://resolver.tudelft.nl/uuid:2cd94baf-d34f-4d61-8f29-6cc67dcef31f
Publikováno v:
Regulatory Toxicology and Pharmacology, 1, 48, 87-92
The in vitro dermal absorption kinetics of didecyldimethylammonium chloride (DDAC) was studied after single and multiple exposure. In addition, the influence of biocidal formulations on the absorption of DDAC was investigated. Following dermal exposu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cd175536db305a62b94bf62f8b76a501
http://resolver.tudelft.nl/uuid:6b33f297-e331-49e7-a71f-58c48cf21c1b
http://resolver.tudelft.nl/uuid:6b33f297-e331-49e7-a71f-58c48cf21c1b
Publikováno v:
Toxicology Letters, Supplement 1, 172, S13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c3797af48bbe5bfa1ad735787228da83
http://resolver.tudelft.nl/uuid:9c7b299d-f52d-424a-856e-4268c840eb22
http://resolver.tudelft.nl/uuid:9c7b299d-f52d-424a-856e-4268c840eb22
Publikováno v:
Roberts, M.S.Walters, K.A., Dermal absorption and toxicity assessment, 2nd ed., 323-338
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e04e46182a39e67048e783bc94db478d
http://resolver.tudelft.nl/uuid:33f05f3f-8222-4124-bc65-2bf688092d00
http://resolver.tudelft.nl/uuid:33f05f3f-8222-4124-bc65-2bf688092d00
Autor:
Kroes, R., Renwick, A.G., Feron, V., Galli, C.L., Gibney, M., Greim, H., Guy, R.H., Lhuguenot, J.C., Sandt, J.J.M. van de
Publikováno v:
Food and Chemical Toxicology, 12, 45, 2533-2562
The threshold of toxicological concern (TTC) has been used for the safety assessment of packaging migrants and flavouring agents that occur in food. The approach compares the estimated oral intake with a TTC value derived from chronic oral toxicity d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d9aa5d43824ac84e98c1473e2ba592e2
http://resolver.tudelft.nl/uuid:f8fd6371-f5eb-4652-b097-f0cee3c932b8
http://resolver.tudelft.nl/uuid:f8fd6371-f5eb-4652-b097-f0cee3c932b8
Publikováno v:
Toxicology Letters, 1, 165, 79-87
The new EU legislations for chemicals (Registration, Evaluation and Authorization of Chemicals, REACH) and cosmetics (Seventh Amendment) stimulate the acceptance of in vitro and in silico approaches to test chemicals for their potential to cause repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8da772cc4781b6e3c76278f03605f457
http://resolver.tudelft.nl/uuid:d2d436ff-4805-486d-9180-6cbbac82249e
http://resolver.tudelft.nl/uuid:d2d436ff-4805-486d-9180-6cbbac82249e
Autor:
Schutte, M.E., Freidig, A.P., Sandt, J.J.M. van de, Alink, G.M., Rietjens, I.M.C.M., Groten, J.P.
Publikováno v:
Toxicology and Applied Pharmacology, 2, 217, 204-215
The present study describes the effect of different flavonoids on the absorption of the pro-carcinogen PhIP through Caco-2 monolayers and the development of an in silico model describing this process taking into account passive diffusion and active t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::eae9a06a509e4c888e038b9dacf25bd2
http://resolver.tudelft.nl/uuid:e2be7c1d-a09d-47b4-9964-e38d1c9d90e9
http://resolver.tudelft.nl/uuid:e2be7c1d-a09d-47b4-9964-e38d1c9d90e9
Autor:
Zuang, V., Alonso, M.A., Botham, P.A., Eskes, C., Fentem, J., Liebsch, M., Sandt, J.J.M. van de
Publikováno v:
ATLA Alternatives to Laboratory Animals, SUPPL. 1, 33, 35-46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7bca559e6b8cebd287c31e86267ef634
http://resolver.tudelft.nl/uuid:a0cfa09e-8803-48a8-bdfd-85acadc9b08a
http://resolver.tudelft.nl/uuid:a0cfa09e-8803-48a8-bdfd-85acadc9b08a