Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients

Autor: Kroes, R., Renwick, A.G., Feron, V., Galli, C.L., Gibney, M., Greim, H., Guy, R.H., Lhuguenot, J.C., van de Sandt, J.J.M.

Publikováno v: In Food and Chemical Toxicology 2007 45(12):2533-2562

Assessment of Some Critical Factors in the Freezing Technique for the Cryopreservation of Precision-Cut Rat Liver Slices

Autor: Maas, W.J.M., de Graaf, I.A.M., Schoen, E.D., Koster, H.J., van de Sandt, J.J.M., Groten, J.P.

Publikováno v: In Cryobiology May 2000 40(3):250-263

Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites

Autor: Louisse, J., Bai, Y., Verwei, M., van de Sandt, J.J.M., Blaauboer, B.J., Rietjens, I.M.C.M., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS

Publikováno v: Toxicology and Applied Pharmacology, 2, 245, 236-243
Toxicology and Applied Pharmacology 245 (2010) 2
Toxicology and Applied Pharmacology, 245(2), 236. Academic Press Inc.
Toxicology and Applied Pharmacology, 245(2), 236-243

Embryotoxicity of glycol ethers is caused by their alkoxyacetic acid metabolites, but the mechanism underlying the embryotoxicity of these acid metabolites is so far not known. The present study investigates a possible mechanism underlying the embryo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc03d50971a74b382c2503d5a51d30a3
http://resolver.tudelft.nl/uuid:2a12b5b5-eb14-44c1-a686-472d34929f8e

Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds

Autor: de Jong, E., Louisse, J., Verwei, M., Blaauboer, B.J., van de Sandt, J.J.M., Woutersen, R.A., Rietjens, I.M.C.M., Piersma, A.H., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS

Publikováno v: Toxicological Sciences, 110(1), 117. Oxford University Press

The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cf6fbd06b9afba058a47745163a9ddf1
https://dspace.library.uu.nl/handle/1874/39323

Relative absorption and dermal loading of chemical substances: Consequences for risk assessment

Autor: Buist, H.E., Schaafsma, G., Sandt, J.J.M. van de

Publikováno v: Regulatory Toxicology and Pharmacology, 3, 54, 221-228

Quantification of skin absorption is an essential step in reducing the uncertainty of dermal risk assessment. Data from literature indicate that the relative dermal absorption of substances is dependent on dermal loading. Therefore, an internal expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::977f62753d8e8ac5cc046842f1e7975d
http://resolver.tudelft.nl/uuid:e9ae718f-3254-471d-8fab-03aa4052f1f6