Development of an attenuated vaccine against Koi Herpesvirus Disease (KHVD) suitable for oral administration and immersion

Autor: Sandro Klafack, Lars Schröder, Yeonhwa Jin, Matthias Lenk, Pei-Yu Lee, Walter Fuchs, Jean-Christophe Avarre, Sven M. Bergmann

Publikováno v: npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)

Abstract Since the end of the1990ies, Cyprinid herpesvirus 3 (also known as koi herpesvirus, KHV) has caused mass mortality events of koi and common carp all over the globe. This induced a high economic impact, since the KHV disease cannot be cured u

Externí odkaz: https://doaj.org/article/537b81bec56649488c60fcc821293179

Genetic Variability of Koi Herpesvirus In vitro—A Natural Event?

Autor: Sandro Klafack, Qing Wang, Weiwei Zeng, Yingying Wang, Yingying Li, Shucheng Zheng, Jolanta Kempter, Pei-Yu Lee, Marek Matras, Sven M. Bergmann

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

Worldwide koi herpesvirus (KHV) causes high mortalities in Cyprinus carpio L. aquaculture. So far, it is unknown how the different variants of KHV have developed and how they spread in the fish, but also in the environmental water bodies. Therefore,

Externí odkaz: https://doaj.org/article/3cc62adf42fb41a2819979dfdd89d015

Structural variation turnovers and defective genomes: key drivers for the in vitro evolution of the large double-stranded DNA koi herpesvirus (KHV)

Autor: Nurul Novelia Fuandila, Anne-Sophie Gosselin-Grenet, Marie-Ka Tilak, Sven M Bergmann, Jean-Michel Escoubas, Sandro Klafack, Angela Mariana Lusiastuti, Munti Yuhana, Anna-Sophie Fiston-Lavier, Jean-Christophe Avarre, Emira Cherif

Publikováno v: Peer Community Journal. Section: Infections (2804-3871) (Centre Mersienne), 2022-07-29, Vol. 2, P. e44 (14p.)
Peer Community Journal
Peer Community Journal, 2022, ⟨10.24072/pcjournal.154⟩

Structural variations (SVs) constitute a significant source of genetic variability in virusgenomes. Yet knowledge about SV variability and contribution to the evolutionaryprocess in large double-stranded (ds)DNA viruses is limited. Cyprinid herpesvir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe8b9d2c82c465bb7fecd9c41d38314
https://doi.org/10.24072/pcjournal.154

Generation of a potential koi herpesvirus live vaccine by simultaneous deletion of the viral thymidine kinase and dUTPase genes

Autor: Sven Bergmann, Dirk Höper, Lars Schröder, Yeonhwa Jin, Walter Fuchs, Sandro Klafack, Thomas C. Mettenleiter, Pei-Yu Lee, Dieter Fichtner

Publikováno v: Journal of General Virology. 100:642-655

Koi herpesvirus (KHV, Cyprinidherpesvirus 3) causes a fatal disease of koi and common carp. To obtain safe and efficacious live vaccines, we generated deletion mutants of KHV lacking the nonessential genes encoding two enzymes of nucleotide metabolis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dcfa3dd3363ba9e2687e32b9c88150
https://doi.org/10.1099/jgv.0.001148

Serological responses to koi herpesvirus (KHV) in a non-cyprinid reservoir host

Autor: Qing Wang, Yingying Wang, Sven Bergmann, Jolanta Kiełpińska, Yingying Li, Pei-Yu Lee, Weiwei Zeng, Yeonwha Jin, Arndt Christian Hofmann, Sean J. Monaghan, Juliane Dabels, Yijuan Jin, Shucheng Zheng, Sandro Klafack, Angela Mariana Lusiastuti

Publikováno v: Journal of fish diseasesREFERENCES. 44(8)

Koi herpesvirus (KHV) is a highly contagious virus that causes KHV disease (KHVD) inducing high mortality in carp and koi (Cyprinus carpio L.). In the late stage, latency occurs with very low, often non-detectable virus concentrations, which represen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b43d9e73e7b412a3f00f02c5daf2c3
https://pubmed.ncbi.nlm.nih.gov/33973665