Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sandro Holzer"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Primase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase a
Externí odkaz:
https://doaj.org/article/7cfdb2fe31884bb48802905f35b30707
Autor:
Mairi L. Kilkenny, Aline C. Simon, Jack Mainwaring, David Wirthensohn, Sandro Holzer, Luca Pellegrini
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
A dynamic multi-protein assembly known as the replisome is responsible for DNA synthesis in eukaryotic cells. In yeast, the hub protein Ctf4 bridges DNA helicase and DNA polymerase and recruits factors with roles in metabolic processes coupled to DNA
Externí odkaz:
https://doaj.org/article/d02f8648c818478099e9295c0dede697
Autor:
Joseph D. Maman, Cara B. Eldridge, Davide Schiavone, Julian E. Sale, Alice Bittleston, Luca Pellegrini, Sandro Holzer, Dana Branzei, Saša Šviković, Katherine Stott, Leticia K. Lerner, Mairi L. Kilkenny, Pierre Murat
Publikováno v:
EMBO J
EMBO Journal
EMBO Journal, EMBO Press, 2020, 39 (18), ⟨10.15252/embj.2019104185⟩
The EMBO Journal
EMBO Journal
EMBO Journal, EMBO Press, 2020, 39 (18), ⟨10.15252/embj.2019104185⟩
The EMBO Journal
Regions of the genome with the potential to form secondary DNA structures pose a frequent and significant impediment to DNA replication and must be actively managed in order to preserve genetic and epigenetic integrity. How the replisome detects and
Autor:
Mairi L. Kilkenny, Alice Bittleston, Dana Branzei, Pierre Murat, Julian E. Sale, Katherine Stott, Leticia K. Lerner, Davide Schiavone, Joseph D. Maman, Sandro Holzer, Luca Pellegrini, Saša Šviković
Regions of the genome with the potential to form secondary structure pose a frequent and significant impediment to DNA replication and must be actively managed in order to preserve genetic and epigenetic integrity. The fork protection complex (FPC),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc65ff41f6736b0e546dec2c6965d38
https://doi.org/10.1101/826578
https://doi.org/10.1101/826578
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The first phosphodiester linkage made during DNA replication is in the context of a short RNA primer synthesized by the dedicated RNA polymerase, primase. Primase, after synthesizing a defined short oligoribonucleotide, then transfers th
Autor:
Sandro Holzer, Gianluca Degliesposti, Mairi L Kilkenny, Sarah L Maslen, Dijana Matak-Vinkovíc, Mark Skehel, Luca Pellegrini
Publikováno v:
Nucleic Acids Research
Human Timeless is involved in replication fork stabilization, S-phase checkpoint activation and establishment of sister chromatid cohesion. In the cell, Timeless forms a constitutive heterodimeric complex with Tipin. Here we present the 1.85 Å cryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60e23b2cca62221c645da37ed57dcac
https://www.repository.cam.ac.uk/handle/1810/263590
https://www.repository.cam.ac.uk/handle/1810/263590
Publikováno v:
JOURNAL OF MOLECULAR BIOLOGY
Eukaryotic ribosome assembly involves a plethora of factors, which ensure that a correctly folded ribosome contains all ribosomal protein components. Among these assembly factors, Yar1 has recently emerged as a molecular chaperone for ribosomal prote