Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sandro Belvedere"'
Autor:
Domenico Accili, Shivatra C Talchai, Ryotaro Bouchi, April Yun‐Kyoung Lee, Wen Du, Takumi Kitamoto, Wendy M McKimpson, Sandro Belvedere, Hua V Lin
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 7, Pp 797-804 (2024)
Abstract Insulin‐deficient (type 1) diabetes is treated by providing insulin to maintain euglycemia. The current standard of care is a quasi‐closed loop integrating automated insulin delivery with a continuous glucose monitoring sensor. Cell repl
Externí odkaz:
https://doaj.org/article/ee8eb11cae5a43188421515e83dca9c4
Autor:
Ja-Young Jang, Inah Hwang, Heng Pan, Jun Yao, Lapo Alinari, Eddie Imada, Claudio Zanettini, Michael J. Kluk, Yizhe Wang, Yunkyoung Lee, Hua V. Lin, Xiangao Huang, Maurizio Di Liberto, Zhengming Chen, Karla V. Ballman, Lewis C. Cantley, Luigi Marchionni, Giorgio Inghirami, Olivier Elemento, Robert A. Baiocchi, Selina Chen-Kiang, Sandro Belvedere, Hongwu Zheng, Jihye Paik
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Targeting lineage-defined transcriptional dependencies has emerged as an effective therapeutic strategy in cancer treatment. Through screening for molecular vulnerabilities of mantle cell lymphoma (MCL), we identified a set of transcription factors (
Externí odkaz:
https://doaj.org/article/e15c9cf4b48849f098c33b46bf6b5433
Autor:
Wen Du, Junqiang Wang, Taiyi Kuo, Liheng Wang, Wendy M. McKimpson, Jinsook Son, Hitoshi Watanabe, Takumi Kitamoto, Yunkyoung Lee, Remi J. Creusot, Lloyd E. Ratner, Kasi McCune, Ya-Wen Chen, Brendan H. Grubbs, Matthew E. Thornton, Jason Fan, Nishat Sultana, Bryan S. Diaz, Iyshwarya Balasubramanian, Nan Gao, Sandro Belvedere, Domenico Accili
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
As a highly regenerative organ, the intestine is a promising source for cellular reprogramming for replacing lost pancreatic β cells in diabetes. Gut enterochromaffin cells can be converted to insulin-producing cells by forkhead box O1 (FoxO1) ablat
Externí odkaz:
https://doaj.org/article/6174ce1f4c8746e499f9f6f5c41100df
Autor:
Yun-Kyoung Lee, Wen Du, Yaohui Nie, Bryan Diaz, Nishat Sultana, Takumi Kitamoto, Rudolph L. Leibel, Domenico Accili, Sandro Belvedere
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101618- (2022)
Objectives: Insulin treatment remains the sole effective intervention for Type 1 Diabetes. Here, we investigated the therapeutic potential of converting intestinal epithelial cells to insulin-producing, glucose-responsive β-like cells by targeted in
Externí odkaz:
https://doaj.org/article/5b916d96958240c9a77147b77b3d5577
Autor:
Takumi Kitamoto, Yun-Kyoung Lee, Nishat Sultana, Hitoshi Watanabe, Wendy M. McKimpson, Wen Du, Jason Fan, Bryan Diaz, Hua V. Lin, Rudolph L. Leibel, Sandro Belvedere, Domenico Accili
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101624- (2022)
Objective: Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose-responsive β-like cells. Here, we tested whether chemical FoxO1 inhibitors
Externí odkaz:
https://doaj.org/article/df93c47e5c174cc68dabf3af76c69142
Autor:
Yun-Kyoung Lee, Bryan Diaz, Marianne Deroose, Samuel X. Lee, Sandro Belvedere, Domenico Accili, Rudolph L. Leibel, Hua V. Lin
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101187- (2021)
Objective: Forkhead box protein O1 (FOXO1) plays a key role in regulating hepatic glucose production, but investigations of FOXO1 inhibition as a potential therapeutic approach have been hampered by a lack of selective chemical inhibitors. By profili
Externí odkaz:
https://doaj.org/article/638a5b8971d74b309029bffc59f3e20e
Autor:
Wen Du, Junqiang Wang, Taiyi Kuo, Liheng Wang, Wendy M. McKimpson, Jinsook Son, Hitoshi Watanabe, Takumi Kitamoto, YunKyoung Lee, Lloyd E. Ratner, Kasi McCune, Ya-Wen Chen, Brendan H. Grubbs, Matthew E. Thornton, Jason Fan, Nishat Sultana, Bryan Diaz, Iyshwarya Balasubramanian, Nan Gao, Sandro Belvedere, Domenico Accili
Insulin is the essential treatment of Type 1 (T1D) and is often used in Type 2 Diabetes. For nearly five decades, efforts have been focused on replenishing β-cells in T1D patients as a more durable treatment. Gut endocrine cells can be converted int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1939f0ab8059648a65e1214cada3dd4
https://doi.org/10.1101/2022.03.21.484748
https://doi.org/10.1101/2022.03.21.484748
Autor:
Ja-Young Jang, Inah Hwang, Heng Pan, Michael Kluk, Jun Yao, Xiangao Huang, Maurizio Di Liberto, Zhengming Chen, Karla V Ballman, Lewis C Cantley, Giorgio Inghirami, Olivier Elemento, Robert Baiocchi, Selina Chen-Kiang, Sandro Belvedere, Hongwu Zheng, Jihye Paik
Publikováno v:
Blood. 138:30-30
Mantle cell lymphoma (MCL) often has an adverse prognosis and despite aggressive multimodal treatment with conventional and targeted therapies, the median survival of MCL patients remains approximately 4 years. Thus, there is a significant unmet need
Autor:
Charles Ingalls, Sandro Belvedere, Zhenzhuang Cheng, Shixian Deng, Jiaming Yan, Ferenc Kontes
Publikováno v:
Organic Process Research & Development. 21:1801-1805
We report an efficient and scalable synthesis of 7-methoxy-2,3,4,5-tetrahydrobenzo[1,4]thiazepine, the core structure of biologically active molecules like JTV-519 and S107. This synthetic route, starting with 4-methoxythiophenol and proceeding via a
Autor:
Sandro Belvedere, Liqiang Chen, J. Paul Secrist, Thomas A. Miller, Ralph T. Mosley, David J. Witter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4562-4567
Benzo[b]thienyl hydroxamic acids, a novel class of histone deacetylase (HDAC) inhibitors, were identified via a targeted screen of small molecule hydroxamic acids. Various substitutions were explored in the C5- and C6-positions of the benzo[b]thiophe