Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Sandro, Cosconati"'
Autor:
Alessandra Del Bene, Antonia D'Aniello, Stefano Tomassi, Francesco Merlino, Vincenzo Mazzarella, Rosita Russo, Angela Chambery, Sandro Cosconati, Salvatore Di Maro, Anna Messere
Publikováno v:
Ultrasonics Sonochemistry, Vol 95, Iss , Pp 106360- (2023)
Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of the PNA synthesis (US-PNAS). When compared wi
Externí odkaz:
https://doaj.org/article/1fa1eb4d80514de18f3776f1e6ad4b40
Autor:
Elisabetta Barresi, Rahul Ravichandran, Lorenzo Germelli, Andrea Angeli, Emma Baglini, Silvia Salerno, Anna Maria Marini, Barbara Costa, Eleonora Da Pozzo, Claudia Martini, Federico Da Settimo, Claudiu Supuran, Sandro Cosconati, Sabrina Taliani
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1783-1797 (2021)
Carbonic Anhydrase Activators (CAAs) could represent a novel approach for the treatment of Alzheimer’s disease, ageing, and other conditions that require remedial achievement of spatial learning and memory therapy. Within a research project aimed a
Externí odkaz:
https://doaj.org/article/61803acb569c43b59486f5dce895777a
Autor:
Emma Baglini, Rahul Ravichandran, Emanuela Berrino, Silvia Salerno, Elisabetta Barresi, Anna Maria Marini, Monica Viviano, Sabrina Castellano, Federico Da Settimo, Claudiu T. Supuran, Sandro Cosconati, Sabrina Taliani
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1874-1883 (2021)
A library of variously decorated N-phenyl secondary sulphonamides featuring the bicyclic tetrahydroquinazole scaffold was synthesised and biologically evaluated for their inhibitory activity against human carbonic anhydrase (hCA) I, II, IV, and IX. O
Externí odkaz:
https://doaj.org/article/88031813ab9443118c310ad8a0e3ccdb
Autor:
Lucia Scisciola, Federica Sarno, Vincenzo Carafa, Sandro Cosconati, Salvatore Di Maro, Loreta Ciuffreda, Antonella De Angelis, Paola Stiuso, Alessandra Feoli, Gianluca Sbardella, Lucia Altucci, Angela Nebbioso
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 664-683 (2020)
SIRT1, a NAD+-dependent deacetylase, is the most well-studied member of class III histone deacetylases. Due to its wide range of activities and substrate targets, this enzyme has emerged as a major regulator of different physiological processes. Howe
Externí odkaz:
https://doaj.org/article/ab148eec8f404fe591846281178d23fa
Autor:
Ciro Milite, Giorgio Amendola, Alessio Nocentini, Silvia Bua, Alessandra Cipriano, Elisabetta Barresi, Alessandra Feoli, Ettore Novellino, Federico Da Settimo, Claudiu T. Supuran, Sabrina Castellano, Sandro Cosconati, Sabrina Taliani
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1697-1710 (2019)
Inhibition of Carbonic Anhydrases (CAs) has been clinically exploited for many decades for a variety of therapeutic applications. Within a research project aimed at developing novel classes of CA inhibitors (CAIs) with a proper selectivity for certai
Externí odkaz:
https://doaj.org/article/58d8627f9d1b40a0bf23a6ac5f027834
Autor:
Barbara Cosimelli, Giovanni Greco, Sonia Laneri, Ettore Novellino, Antonia Sacchi, Giorgio Amendola, Sandro Cosconati, Roberta Bortolozzi, Giampietro Viola
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1152-1157 (2019)
Nine indole derivatives (9a-i) were tested as potential inhibitors of the Keap1–Nrf2 interaction. This class of compounds increases the intracellular levels of the transcription factor Nrf2 and the consequent expression of enzymes encoded by genes
Externí odkaz:
https://doaj.org/article/edf24db1aad24c54b0f66235e118d0b4
Autor:
Santo Previti, Roberta Ettari, Carla Di Chio, Rahul Ravichandran, Marta Bogacz, Ute A. Hellmich, Tanja Schirmeister, Sandro Cosconati, Maria Zappalà
Publikováno v:
Molecules, Vol 27, Iss 12, p 3765 (2022)
Human African Trypanosomiasis (HAT) is an endemic protozoan disease widespread in the sub-Saharan region that is caused by T. b. gambiense and T. b. rhodesiense. The development of molecules targeting rhodesain, the main cysteine protease of T. b. rh
Externí odkaz:
https://doaj.org/article/5873f4bdecaa4d6e87e4e4cfc50782cc
Autor:
Alexander P. Sobinoff, Salvatore Di Maro, Ronnie R. J. Low, Rosaria Benedetti, Stefano Tomassi, Antonia D’Aniello, Rosita Russo, Ilaria Baglivo, Ugo Chianese, Paolo V. Pedone, Angela Chambery, Anthony J. Cesare, Lucia Altucci, Hilda A. Pickett, Sandro Cosconati
The shelterin component telomeric repeat-binding factor 2 (TRF2) is an essential regulator of telomere homeostasis and genomic stability. Mutations in the TRF2TRFHdomain physically impair t-loop formation and prevent the recruitment of several factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::429618ff1a159961061e4b07ab2d7e6e
https://doi.org/10.1101/2023.02.01.526591
https://doi.org/10.1101/2023.02.01.526591
Autor:
Dario Branco, Beniamino Di Martino, Sandro Cosconati, Dieter Kranzlmueller, Salvatore D’Angelo
Publikováno v:
Advanced Information Networking and Applications ISBN: 9783031286933
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fb67792c4c651e214033ca0405826bb
https://doi.org/10.1007/978-3-031-28694-0_12
https://doi.org/10.1007/978-3-031-28694-0_12
Autor:
Elda Chiaino, Matteo Micucci, Sandro Cosconati, Ettore Novellino, Roberta Budriesi, Alberto Chiarini, Maria Frosini
Publikováno v:
Antioxidants, Vol 9, Iss 9, p 806 (2020)
Oxidative stress (OS) arising from tissue redox imbalance, critically contributes to the development of neurodegenerative disorders. Thus, natural compounds, owing to their antioxidant properties, have promising therapeutic potential. Pres phytum (PR
Externí odkaz:
https://doaj.org/article/1be9c1c5c0914b9eabe27aec03fb58c4