Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms

Autor: Nicolas Flaugnatti, Sandrine Isaac, Leonardo F. Lemos Rocha, Sandrine Stutzmann, Olaya Rendueles, Candice Stoudmann, Nina Vesel, Marc Garcia-Garcera, Amandine Buffet, Thibault G. Sana, Eduardo P. C. Rocha, Melanie Blokesch

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Here, the authors study the impact of Vibrio cholerae’s T6SS on human gut microbiota isolates and show that certain bacteria are protected from T6SS attacks in an immunity protein-independent manner. Specifically, protection occurred through superi

Externí odkaz: https://doaj.org/article/f76f9f8adc3e4e19aaec1eaf0004848b

The type IV pilus protein PilU functions as a PilT-dependent retraction ATPase.

Autor: David W Adams, Jorge M Pereira, Candice Stoudmann, Sandrine Stutzmann, Melanie Blokesch

Publikováno v: PLoS Genetics, Vol 15, Iss 9, p e1008393 (2019)

Type IV pili are dynamic cell surface appendages found throughout the bacteria. The ability of these structures to undergo repetitive cycles of extension and retraction underpins their crucial roles in adhesion, motility and natural competence for tr

Externí odkaz: https://doaj.org/article/fcb8770924504d21afce7d54c099c8b8

Independent Regulation of Type VI Secretion in Vibrio cholerae by TfoX and TfoY

Autor: Lisa C. Metzger, Sandrine Stutzmann, Tiziana Scrignari, Charles Van der Henst, Noémie Matthey, Melanie Blokesch

Publikováno v: Cell Reports, Vol 15, Iss 5, Pp 951-958 (2016)

Type VI secretion systems (T6SSs) are nanomachines used for interbacterial killing and intoxication of eukaryotes. Although Vibrio cholerae is a model organism for structural studies on T6SSs, the underlying regulatory network is less understood. A r

Externí odkaz: https://doaj.org/article/146c16bb95c74793ae5fb1bb01b9d955

Single nucleotide polymorphism determines constitutive versus inducible type VI secretion in Vibrio cholerae

Autor: Natália C. Drebes Dörr, Alexis Proutière, Milena Jaskólska, Sandrine Stutzmann, Loriane Bader, Melanie Blokesch

Publikováno v: The ISME Journal

Vibrio cholerae is a well-studied human pathogen that is also a common inhabitant of marine habitats. In both environments, the bacterium is subject to interbacterial competition. A molecular nanomachine that is often involved in such competitive beh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb5dfd3ab574ac90486c6643c43b1ca
https://doi.org/10.1038/s41396-022-01234-7

Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms

Autor: Amandine Buffet, Sandrine Isaac, Marc Garcia-Garcera, Candice Stoudmann, Thibault G. Sana, Nicolas Flaugnatti, Nina Vesel, Leonardo F. Lemos Rocha, Sandrine Stutzmann, Eduardo P. C. Rocha, Olaya Rendueles, Melanie Blokesch

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), 13 p. ⟨10.1038/s41467-021-26041-0⟩
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications, 2021, 12 (1), 13 p. ⟨10.1038/s41467-021-26041-0⟩

While the major virulence factors for Vibrio cholerae, the cause of the devastating diarrheal disease cholera, have been extensively studied, the initial intestinal colonization of the bacterium is not well understood because non-human adult animals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d2a17b0e12945c6ec6a40ff6b57177
https://doi.org/10.1038/s41467-021-26041-0