Výsledky vyhledávání - "Sandrine Saugues"

Akademický článek

Value of combining biological age with assessment of individual frailty to optimize management of cancer treated with targeted therapies: model of chronic myeloid leukemia treated with tyrosine kinase inhibitors (BIO-TIMER trial)

Autor: Mélanie Casile, Gilles Albrand, Clément Lahaye, Benjamin Lebecque, Joévin Besombes, Céline Bourgne, Bruno Pereira, Sandrine Saugues, Caroline Jamot, Eric Hermet, Marc G. Berger

Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-8 (2024)

Abstract Background In the era of targeted therapies, the influence of aging on cancer management varies from one patient to another. Assessing individual frailty using geriatric tools has its limitations, and is not appropriate for all patients espe

Externí odkaz: https://doaj.org/article/b90c13fde20d48e3b3076191bb5f84cf

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Akademický článek

The initial molecular response predicts the deep molecular response but not treatment-free remission maintenance in a real-world chronic myeloid leukemia cohort

Autor: Sandrine Saugues, Céline Lambert, Elisabeth Daguenet, Gabrielle Roth-Guepin, Françoise Huguet, Pascale Cony-Makhoul, Hyacinthe Johnson Ansah, Martine Escoffre-Barbe, Ali Turhan, Philippe Rousselot, Andreï Tchirkov, Dalil Hamroun, Eric Hermet, Bruno Pereira, Marc G. Berger

Publikováno v: Haematologica, Vol 999, Iss 1 (2024)

In chronic myeloid leukemia, the identification of early molecular predictors of stable treatment-free remission (TFR) after tyrosine kinase inhibitor (TKI) discontinuation is challenging. The predictive values of residual disease (BCR::ABL1 quantifi

Externí odkaz: https://doaj.org/article/dbb677be8c894264a285996183d0ab11

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Akademický článek

Efficiency of nilotinib to target chronic phase-chronic myeloid leukaemia primary mature CD34− and immature CD34+ cells

Autor: Marc G. Berger, Benjamin Lebecque, Thomas Tassin, Louis-Thomas Dannus, Juliette Berger, Mélanie Soucal, Agnès Guerci, Pascale Cony-Makhoul, Hyacinthe Johnson, Gabriel Etienne, Denis Guyotat, Marie-Claude Gagnieu, Bruno Pereira, Sandrine Saugues, Olivier Tournilhac, Eric Hermet, Céline Bourgne

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Accumulation in target cells is an essential pharmacokinetic step of targeted therapies. Tyrosine Kinase Inhibitors (TKI) against the BCR-ABL fusion protein in Chronic Phase-Chronic Myeloid Leukaemia (CP-CML) cells constitute a unique model

Externí odkaz: https://doaj.org/article/dba1f40c656e42c3b03434ba4b592551

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Akademický článek

DNA methylation profiling reveals a pathological signature that contributes to transcriptional defects of CD34+CD15− cells in early chronic‐phase chronic myeloid leukemia

Autor: Stéphanie Maupetit‐Mehouas, Franck Court, Céline Bourgne, Agnès Guerci‐Bresler, Pascale Cony‐Makhoul, Hyacinthe Johnson, Gabriel Etienne, Philippe Rousselot, Denis Guyotat, Alexandre Janel, Eric Hermet, Sandrine Saugues, Juliette Berger, Philippe Arnaud, Marc G. Berger

Publikováno v: Molecular Oncology, Vol 12, Iss 6, Pp 814-829 (2018)

Despite the high efficiency of tyrosine kinase inhibitors (TKI), some patients with chronic myeloid leukemia (CML) will display residual disease that can become resistant to treatment, indicating intraclonal heterogeneity in chronic‐phase CML (CP�

Externí odkaz: https://doaj.org/article/b9748f2553f944a0a5f7f0ba157e2821

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Real-world therapeutic response and tyrosine kinase inhibitor discontinuation in chronic phase-chronic myeloid leukemia: data from the French observatory

Autor: Sandrine Saugues, Céline Lambert, Elisabeth Daguenet, Hyacinthe Johnson Ansah, Ali Turhan, Françoise Huguet, Agnès Guerci-Bresler, Andreï Tchirkov, Dalil Hamroun, Eric Hermet, Bruno Pereira, Marc G. Berger

Publikováno v: Annals of hematology. 101(10)

Guidelines for tyrosine kinase inhibitor (TKI)-treated chronic phase-chronic myeloid leukemia (CML) management are essentially based on data from clinical research trials; however, real-world data should be valuable for optimizing such recommendation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3b528c68d867fb0848d6dac20daeb5
https://pubmed.ncbi.nlm.nih.gov/36040480

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The Spliceosome: A New Therapeutic Target in Chronic Myeloid Leukaemia

Autor: Benjamin Lebecque, Celine Bourgne, Chinmay Munje, Juliette Berger, Thomas Tassin, Pascale Cony-Makhoul, Agnès Guerci-Bresler, Hyacinthe Johnson-Ansah, Wei Liu, Sandrine Saugues, Andrei Tchirkov, David Vetrie, Mhairi Copland, Marc G. Berger

Publikováno v: Cancers; Volume 14; Issue 19; Pages: 4695

RNA splicing factors are frequently altered in cancer and can act as both oncoproteins and tumour suppressors. They have been found mutated or deregulated, justifying the growing interest in the targeting of splicing catalysis, splicing regulatory pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d85ab8f98966eb11ff4e67f6a9ae231
https://doi.org/10.3390/cancers14194695

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Longer treatment duration and history of osteoarticular symptoms predispose to tyrosine kinase inhibitor withdrawal syndrome

Autor: Sandrine Saugues, Joelle Guilhot, Céline Lambert, Bruno Pereira, Susanne Saussele, Franck-Emmanuel Nicolini, Laurence Legros, Martine Escoffre-Barbe, Agnès Guerci-Bresler, Delphine Rea, Philippe Rousselot, Marc G. Berger, Martine Gardembas, Stéphane Giraudier, Pascale Cony-Makhoul, Francois-Xavier Mahon

Publikováno v: British Journal of Haematology
British Journal of Haematology, Wiley, 2019, 187 (3), pp.337-346. ⟨10.1111/bjh.16083⟩

The effectiveness of tyrosine kinase inhibitors (TKIs) has made it possible to consider treatment discontinuation in chronic myeloid leukaemia (CML) patients that achieve an excellent response. However, a few of the patients included in the Europe St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628dfe44c55305199306f0ae92f32fd0
https://doi.org/10.1111/bjh.16083

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Efficiency of nilotinib to target chronic phase-chronic myeloid leukaemia primary mature CD34− and immature CD34+ cells

Autor: Gabriel Etienne, Olivier Tournilhac, Bruno Pereira, Agnès Guerci, Marc G. Berger, Pascale Cony-Makhoul, Benjamin Lebecque, Eric Hermet, Thomas Tassin, Mélanie Soucal, Juliette Berger, Denis Guyotat, Sandrine Saugues, Hyacinthe Johnson, Céline Bourgne, Louis-Thomas Dannus, Marie-Claude Gagnieu

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-85734-0⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Accumulation in target cells is an essential pharmacokinetic step of targeted therapies. Tyrosine Kinase Inhibitors (TKI) against the BCR-ABL fusion protein in Chronic Phase-Chronic Myeloid Leukaemia (CP-CML) cells constitute a unique model in terms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9b70ccd2d330f25d4cb3f84d9db83f
https://hal.uca.fr/hal-03278034

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