Výsledky vyhledávání - "Sandrine Rosario"

Akademický článek

How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA

Autor: Dariusz Czernecki, Pierre Legrand, Mustafa Tekpinar, Sandrine Rosario, Pierre-Alexandre Kaminski, Marc Delarue

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

The cyanophage S-2L incorporates 2-aminoadenine (Z) instead of adenine (A) in its genome. Here, the authors provide an explanation for the absence of A in S-2L genome by identifying and characterising functionally and structurally both the HD phospho

Externí odkaz: https://doaj.org/article/abe6a0fc434445db8149e9dae08610a3

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Akademický článek

Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli.

Autor: Clément Madru, Ayten Dizkirici Tekpinar, Sandrine Rosario, Dariusz Czernecki, Sébastien Brûlé, Ludovic Sauguet, Marc Delarue

Publikováno v: PLoS ONE, Vol 16, Iss 4, p e0250610 (2021)

To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million deaths to date, new antiviral molecules are urgently needed. The replication of SARS-CoV-2 requires the RNA-depe

Externí odkaz: https://doaj.org/article/420e08afabc54742ac1f3b295bdff275

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Structural evidence for an in trans base selection mechanism involving Loop1 in polymerase μ at an NHEJ double-strand break junction

Autor: Marc Delarue, Sandrine Rosario, Michael R. Lieber, Jérôme Loc’h, Christina A. Gerodimos, Mustafa Tekpinar

Publikováno v: J Biol Chem
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2019, pp.jbc.RA119.008739. ⟨10.1074/jbc.RA119.008739⟩
Journal of Biological Chemistry, 2019, pp.jbc.RA119.008739. ⟨10.1074/jbc.RA119.008739⟩

International audience; Eukaryotic DNA polymerase (Pol) X family members such as Pol μ and terminal deoxynucleotidyl transferase (TdT) are important components for the nonhomologous DNA end-joining (NHEJ) pathway. TdT participates in a specialized v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d071df0610392eb7c9f8393ac491f2
https://europepmc.org/articles/PMC6615693/

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Structural Basis for a New Templated Activity by Terminal Deoxynucleotidyl Transferase: Implications for V(D)J Recombination

Autor: Sandrine Rosario, Jérôme Loc’h, Marc Delarue

Publikováno v: Structure
Structure, Elsevier (Cell Press), 2016, 24 (9), pp.1452-1463. ⟨10.1016/j.str.2016.06.014⟩
Structure, 2016, 24 (9), pp.1452-1463. ⟨10.1016/j.str.2016.06.014⟩

International audience; Eukaryotic DNA polymerase of the polX family, such as pol μ and terminal deoxynucleotidyl transferase (TdT), are key components of the non-homologous end-joining or V(D)J recombination machinery, respectively. The established

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25dce4551e4d792e5f10e9f943fbe26
https://pubmed.ncbi.nlm.nih.gov/27499438

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Soluble and glyco-lipid modified baculovirus Plasmodium falciparum C-terminal merozoite surface protein 1, two forms of a leading malaria vaccine candidate

Autor: Sandrine Rosario, Charles Roth, Sarah Bonnet, Inge Holm, Shirley Longacre, Thierry Fontaine, Stéphane Petres

Publikováno v: Vaccine
Vaccine, 2006, 24 (33-34), pp.5997-6008. ⟨10.1016/j.vaccine.2006.04.069⟩

International audience; Recombinant homologues of the Plasmodium merozoite surface protein 1 C-terminus are leading blood stage malaria vaccine candidates. MSP1 is anchored to the merozoite plasma membrane in vivo by a glycosyl-phosphatidyl-inositol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162968a0b90f636e11c453841515619b
https://doi.org/10.1016/j.vaccine.2006.04.069

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Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism

Autor: Marc Delarue, Felix Romain, Jerome Gouge, Sandrine Rosario, Pierre Béguin

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2013, 425 (22), pp.4334-4352. ⟨10.1016/j.jmb.2013.07.009⟩
Journal of Molecular Biology, 2013, 425 (22), pp.4334-4352. ⟨10.1016/j.jmb.2013.07.009⟩

International audience; Terminal deoxynucleotidyltransferase (Tdt) is a non-templated eukaryotic DNA polymerase of the polX family that is responsible for the random addition of nucleotides at the V(D)J junctions of immunoglobulins and T-cell recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59028c68803a9c52064bd4a85d088521
https://hal-pasteur.archives-ouvertes.fr/pasteur-02174639

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Rapid enzymatic synthesis of long RNA polymers: A simple protocol to generate RNA libraries with random sequences

Autor: Marc Delarue, Irina Randrianjatovo-Gbalou

Publikováno v: Methods
Methods, Elsevier, 2019, 161, pp.83-90. ⟨10.1016/j.ymeth.2019.03.025⟩
Methods, 2019, 161, pp.83-90. ⟨10.1016/j.ymeth.2019.03.025⟩

International audience; RNA aptamers have several advantages over DNA aptamers due to their propensity to fold into three-dimensional structures. However, the synthesis of large RNA libraries remains a challenge as it requires more precautions to con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0858e1c74b5e5b05c73dd081faa9aa9d
https://hal-pasteur.archives-ouvertes.fr/pasteur-02170317/document

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