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pro vyhledávání: '"Sandrine Ngaha"'
Autor:
Oliver Pilgram, Aline Keils, Gerrit E. Benary, Janis Müller, Stefan Merkl, Sandrine Ngaha, Simon Huber, Florent Chevillard, Anne Harbig, Viktor Magdolen, Andreas Heine, Eva Böttcher-Friebertshäuser, Torsten Steinmetzer
Publikováno v:
European Journal of Medicinal Chemistry. 238:114437
A rational structure-based approach was employed to develop novel 3-amidinophenylalanine-derived matriptase inhibitors with improved selectivity against thrombin and factor Xa. Of all 23 new derivatives, several monobasic inhibitors exhibit high matr