Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole‐body homeostasis

Autor: Qing Zhang, Agnès Duplany, Vincent Moncollin, Sandrine Mouradian, Evelyne Goillot, Laetitia Mazelin, Karine Gauthier, Nathalie Streichenberger, Céline Angleraux, Jie Chen, Shuzhe Ding, Laurent Schaeffer, Yann‐Gaël Gangloff

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 1, Pp 35-53 (2019)

Abstract Background The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, partial mTOR inhibition by rapamycin has beneficial ef

Externí odkaz: https://doaj.org/article/481283996c1a43f4bda9799c846af817

LSD1 controls a nuclear checkpoint in Wnt/β-Catenin signaling to regulate muscle stem cell self renewal

Autor: Sandrine Mouradian, Delia Cicciarello, Nicolas Lacoste, Francesca Berretta, Fabien Le Grand, Nicolas Rose, Laurent Schaeffer, Isabella Scionti

The Wnt/β-Catenin pathway plays a key role in cell fate determination during development and in adult tissue regeneration by stem cells. These processes involve profound gene expression and epigenome remodeling and linking Wnt/β-Catenin signaling t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0f84b9a69314f40b37301de6f49bf94
https://doi.org/10.1101/2022.06.10.495614

A Comparative Analysis of Perturbations Caused by a Gene Knock-out, a Dominant Negative Allele, and a Set of Peptide Aptamers

Autor: Sandrine Mouradian-Garcia, Isabelle Michaud-Soret, Nadia Abed, Matthieu Schapira, Pierre Colas, Raquel Sanjuan-España, Marc Bickle, Marie-Odile Fauvarque, Olivier Moncorgé, Brian B. Rudkin, Bernard Mari, Karine Robbe Sermesant, Pascal Barbry

Publikováno v: Molecular and Cellular Proteomics
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2007, 6 (12), pp.2110-2121. ⟨10.1074/mcp.M700105-MCP200⟩
Molecular and Cellular Proteomics, 2007, 6 (12), pp.2110-2121. ⟨10.1074/mcp.M700105-MCP200⟩
Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2007, 6 (12), pp.2110-21. ⟨10.1074/mcp.M700105-MCP200⟩

International audience; The study of protein function mostly relies on perturbing regulatory networks by acting upon protein expression levels or using transdominant negative agents. Here we used the Escherichia coli global transcription regulator Fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a8016ef0c0cec4bc14f602c036a150
https://hal.archives-ouvertes.fr/hal-02975696/file/Michaud-Soret_Abed_2007.pdf

Key role for cyclin-dependent kinases in the first and second meiotic divisions of rat spermatocytes

Autor: Murielle Godet, Anne Damestoy, Sandrine Mouradian, Brian Rudkin, Philippe Durand

Publikováno v: Biology of Reproduction
Biology of Reproduction, 2004, 70 (4), pp.1147-1152
Biology of Reproduction, Society for the Study of Reproduction, 2004, 70 (4), pp.1147-1152
HAL

International audience; In all systems examined so far, the G2/M phase transition is controlled by the M-phase promoting factor (MPF), a complex of cdc2 (CDK1) and cyclin B1. Histone H1 kinase activity and MPF components are present in pachytene sper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4f0140c40a8d04e1ebd00f8fb3d93c52
https://hal.inrae.fr/hal-02680859