LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice

Autor: Michel Mallat, Fabrice Daubigney, Catherine Colin, Sandrine Middendorp, Jean-Christophe Rain, Nadim Kassis, Valerie Hindie, M.L. Arbonés, Blandine Gausserès, Jean-Maurice Delabar, Jean-Louis Paul, Nathalie Janel, Yuchen Gu, Eugene Yu, Alizée Latour

Publikováno v: Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2019, 56 (2), pp.963-975. ⟨10.1007/s12035-018-1113-x⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname

International audience; Down syndrome is characterized by premature aging and dementia with neurological features that mimic those found in Alzheimer's disease. This pathology in Down syndrome could be related to inflammation, which plays a role in o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1f26769338a1ae350f08e7f4bdceea
https://hal-cnrs.archives-ouvertes.fr/hal-03201563

DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels

Autor: Arnaud Duchon, Yann Herault, Nathalie Janel, Asma Tlili, Eva Benabou, Christophe Noll, Jean-Maurice Delabar, Jean-Louis Paul, Marie Jouan, Sandrine Middendorp

Publikováno v: Molecular Genetics and Metabolism. 110:371-377

Background and aims Down syndrome is caused by trisomy of all or part of human chromosome 21. Individuals with Down syndrome present some metabolic abnormalities involving lipoproteins, notably lower high-density lipoprotein levels associated with al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a898e1daa42394771b0f18a79de689
https://doi.org/10.1016/j.ymgme.2013.07.014

Junctional adhesion molecules are required for melanoma cell lines transendothelial migration in vitro

Autor: Stephanie Ghislin, Dorian Obino, Catherine Alcaide-Loridan, Nicole Boggetto, Sandrine Middendorp, Frédérique Deshayes

Publikováno v: Pigment Cell & Melanoma Research. 24:504-511

Summary One of the main steps of metastasis is extravasation, a phenomenon well described in lymphocytes but remaining to be fully uncovered for melanoma. Junctional adhesion molecules (JAMs) control the transendothelial migration of leukocytes. To d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2517164e819491dcdbd64138739c3361
https://doi.org/10.1111/j.1755-148x.2011.00856.x

Cation- and peptide-binding properties of human centrin 2

Autor: Sandrine Middendorp, Isabelle Durussel, Jos A. Cox, Constantin T. Craescu, Yves Blouquit

Publikováno v: FEBS Letters. 472:208-212

Centrin and calmodulin (CaM) are closely related four-EF-hand Ca(2+)-binding proteins. While CaM is monomeric, centrin 2 is dimeric and binds only two Ca(2+) per dimer, likely to site IV in each monomer. Ca(2+) binding to centrin 2 displays pronounce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a3629bf61fc0f50ccd23ec2be9fe3c
https://doi.org/10.1016/s0014-5793(00)01452-6

PHF19 and Akt control the switch between proliferative and invasive states in melanoma

Autor: Catherine Alcaide-Loridan, Frédérique Deshayes, Nicole Boggetto, Sandrine Middendorp, Stephanie Ghislin

Publikováno v: Cell cycle (Georgetown, Tex.). 11(8)

Melanoma tumor cells shift between proliferative and invasive states based on their plasticity and microenvironmental conditions. Our team has shown that melanoma cells, grown as spheroids in a neural cell crest medium, polarize toward an invasive ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d023667ed279f777a4cefe82355bcd8
https://pubmed.ncbi.nlm.nih.gov/22487681