Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sandrine Legg"'
Autor:
Jonathan D. Taylor, Nathalie Barrett, Sergio Martinez Cuesta, Katelyn Cassidy, Fiona Pachl, James Dodgson, Radhika Patel, Tuula M. Eriksson, Aidan Riley, Matthew Burrell, Christin Bauer, D. Gareth Rees, Raffaello Cimbro, Andrew X. Zhang, Ralph R. Minter, James Hunt, Sandrine Legg
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a ‘biological
Externí odkaz:
https://doaj.org/article/82c3864e38134c29b42485f93454e6e6
Autor:
Stacey E. Chin, Christina Schindler, Lisa Vinall, Roger B. Dodd, Lisa Bamber, Sandrine Legg, Anna Sigurdardottir, D. Gareth Rees, Tim I. M. Malcolm, Samantha J. Spratley, Cecilia Granéli, Jonathan Sumner, Natalie J. Tigue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant interest within the synthetic biology community in identifying novel CID systems. To
Externí odkaz:
https://doaj.org/article/1c4fb2f0a98149f7bb083c8fbced398e
Autor:
Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H. Rabbitts
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Mutant RAS family members occur in a wide range of tumour types, and there is a great interest in identifying isoform-specific inhibitors. Here, the authors characterise two designed ankyrin repeat proteins (DARPins) that specifically inhibit the KRA
Externí odkaz:
https://doaj.org/article/d60832bba2a448e1bd87fa3edb2b14fd
Autor:
Stacey Chin, Christina Schindler, Lisa Vinall, Roger Dodd, Lisa Bamber, Sandrine Legg, Anna Sigurdardottir, D. Rees, Tim Malcolm, Samantha Spratley, Natalie Tigue
Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant interest within the synthetic biology community in identifying novel CID systems. To date, CID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c137b243a16d52f270a397ca20c88eea
https://doi.org/10.21203/rs.3.rs-2244031/v1
https://doi.org/10.21203/rs.3.rs-2244031/v1